Thyroid Drugs Flashcards
(26 cards)
Enzyme used to concert iodide ion to iodine
Thyroid peroxidase
Refers to the process where tyrosine residues in the thyroglobulin are iodinated to form MIT or DIT
Iodine organification
process where 2 molecules of DIT is combined to form T4 or 1 MIT to 1 DIT to form T3
coupling
T3 and T3 are released from the thyroid are transported by ____
Thyroxine-binding globulin
peripheral conversion refers to what process
T4 converted to T3 in target cells
what is the half life of T4?
7 days
in terms of volume of distribution, T4 vs T3
T4
Which is more potent?
T4 vs T3
T3
[Guess the drug]
cause myxedema coma
levothyroxine
What are the biologic effects of thyroid hormones?
- Brain maturation
- Bone growth
- Beta-adrenergic effects
- Basal metabolic rate increase
[Guess the drug]
inhibit thyroid peroxidase reaction, inhibit peripheral conversion of T4
causes fulminant hepatitis, agranulocytosis
PTU
What is the drug of choice for pregnant hyperthyroid patients?
PTU
preferable during the first trimester of pregnancy
[Guess the drug]
inhibits thyroid peroxidase reactions; blocks iodine organification
Causes agranulocytosis
methimazole
What is the DOC for non-pregnant hyperthyroid?
methimazole
Can cause aplasia cutis congenita
methimazole
Can cause choanal atresia of and esophageal atresia
methimazole
inhibit iodine organification and hormone release; to reduce vascularity of thyroid gland
acts by thyroglobulin hydrolysis
KISS
prevents radiation-induction thyroid damage
KISS
[what phenomenon]
ingestion of iodine causes hypothyroidism
Wolf-chaikoff
[what phenomenon]
ingestion of iodine causes hyperthyroidsm
Jod-Basedow
[What drug]
Control HR, slows pacemaker, inhibit peripheral conversion
beta blocker
propranolol
beta blockerthat can be used to treat thyrotoxicosis-related arrythmia
esmolol
[What drug]
cause clinical improvement without altering the thyroid hormone level
propranolol
Which drugs inhibit peripheral conversion of T4 to T3?
- Propylthiouracil
- Propranolol
- Hydrocortisone
