E2: L13

Question 1

helper T cells activate

Answer 1

macrophages, Bcells

Question 2

activation of T cell requires cell to cell __

Answer 2

contact

Question 3

effector response is dependent on ___ cytokines

Answer 3

polarizing

Question 4

Th1 subset is created by what cytokine

Answer 4

IL-12

Question 5

TH2 subset is created by what cytokine

Answer 5

IL-4

Question 6

each Th subset has distinct ___ cytokine profile and __ distinct activities

Answer 6

effector, regulates

Question 7

Th subsets are distinguished by 3 properties: __ cytokines, master gene regulator, signature set of effector cytokines

Answer 7

polarizing

Question 8

Th subsets are distinguished by 3 properties: polarizing cytokines, master gene regulator, signature set of effector cytokines

Question 9

Th subsets are distinguished by 3 properties: polarizing cytokines, master gene regulator, signature set of effector cytokines

Question 10

helper T cells interact with antigen presenting cell and respond to __ cytokines

Answer 10

polarizing

Question 11

cytokines activate to specify one specific ___ regulation system that produces specific cytokines

Answer 11

gene

Question 12

Treg cells do what function

Answer 12

suppress immune response

Question 13

Th2 cells do what function

Answer 13

combats helminth infection, activates eosinophils

Question 14

TFH cells do what function

Answer 14

regulates affinity maturation of germinal center B cells

Question 15

TH1 cells do what function

Answer 15

combats intracellular pathogens, activates macrophages

Question 16

a naive interacts with a specific antigen presented by a __ cell

Answer 16

dendritic cell

Question 17

what helper cell is the main line response to inflammation

Answer 17

Th1

Question 18

effector cytokines of Th1

Answer 18

IFN-gamma, TNF

Question 19

effector cytokines of Th2

Answer 19

IL-4,5,13

Question 20

effector cytokines of Treg

Answer 20

IL-10, TGF-beta

Question 21

effector cytokines of Tfh

Answer 21

Il-4,21

Question 22

TGF stands for

Answer 22

transforming growth factor

Question 23

effector cytokine of Helper T1

Answer 23

IFN-gamma

Question 24

effector cytokine of Helper T2

Answer 24

IL-4,5,13

Question 25

interferons enhance ___ T cell activity

Answer 25

cytotoxic

Question 26

Helper type 2 mainly deals with ___and ___

Answer 26

parasites, alllgeries

Question 27

TH cells may be able to morph into another ___

Answer 27

subset

Question 28

TH cell differentiation is ___

Answer 28

fluid

Question 29

fluidity among subsets makes definitive establishment of helper T cell lineages ___

Answer 29

difficult

Question 30

___ ___ commit T cells to one subset or another

Answer 30

master regulators

Question 31

____ suppresses Th2 pathway gene expression

Answer 31

T-Bet

Question 32

___ suppresses Th1 pathway gene expression

Answer 32

GATA3

Question 33

polarizing cytokines IL-6,21 do ___ of master regulator

Answer 33

activation

Question 34

effector cytokines IL4,21 __ B-cell ___

Answer 34

promote, differentiation

Question 35

Tfh cells also express CD__L and CXCR__

Answer 35

40, 5

Question 36

Tfh cells present a receptor for a chemokine that attracts ___

Answer 36

Bcells

Question 37

3 subsets of cytotoxic effector cells

Answer 37

CD8+, NKT lymphocytes, NK cells

Question 38

__ and __ are involved in organ transplant rejection

Answer 38

CTL, NK

Question 39

NKT stands for

Answer 39

Natural killer t lymphocytes

Question 40

cytotoxic effector cells can specify__ cells and abnormal __ cells

Answer 40

infected, tumor

Question 41

can cytotoxic effector cells recognize and kill self cells?

Answer 41

yes

Question 42

CTL effector cells produce

Answer 42

perforins and granzymes

Question 43

NK effector cells produce

Answer 43

perforins and granzymes

Question 44

NKT effector cells produce

Answer 44

FasL

Question 45

all 3 effector cells can be activated by which effector molecule

Answer 45

FasL

Question 46

what effector cell does not produce perforins and granzymes

Answer 46

NKT cells

Question 47

all cytotoxic cells must have cell to cell ___

Answer 47

contact

Question 48

helper T cells bind to MHC 2 and cytotoxic T cells only bind to ___

Answer 48

MHC1

Question 49

phase 2: effector T cells recognize MHC 2 to target and induce cell __

Answer 49

death

Question 50

2 pathways of how CTLs kill target cells

Answer 50

1. perforin and pranzyme 2. Fas-FasL Pathway

Question 51

apoptosis: extrinsic pathway uses a death __. intrinsic pathway uses perforins and gran. via direct __

Answer 51

receptor, contact

Question 52

what stage in CTL mediated killing of a target cell is granzyme released to initiate caspase cascade?

Answer 52

2

Question 53

2 types of CTLs are

Answer 53

Tc1 and Tc2

Question 54

___ uses perforin and fas-mediated death induction

Answer 54

Tc1

Question 55

___ only uses perforin death-induction

Answer 55

Tc2

Question 56

CD8+ is activated by ___

Answer 56

MHC1

Question 57

for a naive cytotoxic cell to be activated, the dendritic cell must be ___ by a __ cell

Answer 57

licensed, Helper T

Question 58

___: Th1 cell tells the ___ cell how to better present.

Answer 58

licensing, dendritic

Question 59

To prevent redirection of self-antigens into APC pathways, dendritic cells may need ___

Answer 59

license

Question 60

___ cells appear to be the primary cross-presenting cell type

Answer 60

Dendritic

Question 61

helper T teaches dendritic cell to activate cytotoxic cells

Question 62

1 dendritic cell can activate ___ cells at one time

Answer 62

several

Question 63

cross-presentation is best because it allows dendritic cells to be more ___

Answer 63

versatile