E2: L14

Question 1

natural killer cells are ___ negative and lack specific ___ receptors and are activated by ___

Answer 1

CD3, antigen, cytokines

Question 2

Ag stands for

Answer 2

antigen

Question 3

interferons associated with viral infections

Answer 3

IFN alpha, beta, and IL-12

Question 4

NK cells act earlier in immune response than ___ T-cells

Answer 4

cytotoxic

Question 5

Natural killer cells mature in ___ tissues

Answer 5

peripheral

Question 6

NK cells can kill cells that have MHC class ___

Answer 6

1

Question 7

NK cells have receptors that are ___/___

Answer 7

activators/inhibitors

Question 8

individual cells have different receptor __ for natural killer cells

Answer 8

amounts

Question 9

NK cells induce cell - ___ apoptosis

Answer 9

mediated

Question 10

NK cells release __ and __ to induce apoptosis

Question 11

natural killer cells cannot do anything until they interact with MHC class __

Answer 11

1

Question 12

NK Tcells are ___ immune response, train in the ___, main Tcell receptor is the ___ - ___ receptor

Answer 12

adaptive, thymus, alpha-beta

Question 13

NK Tcells can have a ___ marker on them

Answer 13

CD4

Question 14

6 mechanisms of antibodies:
1. N___
2. Agglutination
3. Opsonization
4. Activate complement
5. Activate Cytotoxic cells
6. Activate degranulation (inflammation)

Answer 14

neutralize pathogens/toxins

Question 15

6 mechanisms of antibodies:
1. Neutralize pathogens/toxins
2. Agg____
3. Opsonization
4. Activate complement
5. Activate Cytotoxic cells
6. Activate degranulation (inflammation)

Answer 15

Agglutination

Question 16

6 mechanisms of antibodies:
1. Neutralize pathogens/toxins
2. Agglutination
3. O___
4. Activate complement
5. Activate Cytotoxic cells
6. Activate degranulation (inflammation)

Answer 16

Opsonization

Question 17

6 mechanisms of antibodies:
1. Neutralize pathogens/toxins
2. Agglutination
3. Opsonization
4. Activate com___
5. Activate Cytotoxic cells
6. Activate degranulation (inflammation)

Answer 17

Active compliment

Question 18

6 mechanisms of antibodies:
1. Neutralize pathogens/toxins
2. Agglutination
3. Opsonization
4. Activate complement
5. Activate Cyto___
6. Activate degranulation (inflammation)

Answer 18

Cytotoxic cells

Question 19

6 mechanisms of antibodies:
1. Neutralize pathogens/toxins
2. Agglutination
3. Opsonization
4. Activate complement
5. Activate Cytotoxic cells
6. Activate ___ (inflammation)

Answer 19

degranulation

Question 20

general shape of antibodies

Answer 20

Y- shape

Question 21

IgG

Answer 21

most common in body

Question 22

IgA

Answer 22

2 Ys

Question 23

IgD

Answer 23

1 Y

Question 24

IgE

Answer 24

1Y

Question 25

IgM

Answer 25

circle with 5 Y's surrounding it

Question 26

5 Antibodies you need to know: Ig...

Answer 26

A, D, G, E, M

Question 27

heavy chain of an antibody is on the ___ of the Y

Answer 27

stem

Question 28

light chain of an antibody is on the ___ of the Y

Answer 28

Arms

Question 29

antibodies are ___ proteins

Answer 29

soluble

Question 30

constant region of an antibody ___ change

Answer 30

don't

Question 31

the active site of an antibody are highly ___

Answer 31

variable

Question 32

IgG has ___ subtypes

Answer 32

4

Question 33

The IgG subunit with the shortest halflife is ___

Answer 33

IgG3

Question 34

The longest living antibody is ___

Answer 34

IgG

Question 35

IgA has __ subtypes

Answer 35

2

Question 36

IgA has a ____ structure that keeps it from being broken down by a protease

Answer 36

Diamer

Question 37

___ cells are the B cells that secrete antibodies

Answer 37

Plasma

Question 38

____ cells are required to complete the Diamer structure of IgA

Answer 38

Epithelial

Question 39

IgM has ___ binding sites for antigens

Answer 39

10

Question 40

IgM can get broken apart into ___ receptors and are the first antibodies to respond to a viral infection

Answer 40

B-cell

Question 41

The first antibody to respond to an antigen is ___ and then ___

Answer 41

IgM, IgG

Question 42

IgD activates Bcalls and is a maturation marker. Doesn’t activate compliment.

Question 43

IgE is associated with allergic reaction and parasitic reactions

Question 44

Effector function of antibodies depend on the antibody ____

Answer 44

Isotype

Question 45

Isotope is the antibody. ___

Answer 45

Subtype

Question 46

Neutralization prevents a virus from attacking body cell

Question 47

Aggulation enhances neutralization

Question 48

When compliment is activated it can mean ___

Answer 48

Cytoloysis

Question 49

Antibody’s can stimulate natural killer cells and cytotoxic T cells

Question 50

Antibody function matching slide

Question 51

First antibody produced, and has a lower affinity

Answer 51

IgM

Question 52

IgM has many binding sites this means they have a high ____

Answer 52

Avvidity

Question 53

IgG all forms, will bind to a cell with a receptor that has a constant portion for IgG

Question 54

IgG Binds to receptors that enhance phagocytosis by ___

Answer 54

Macrophages

Question 55

IgA Major isotope is found in the ___ and ___

Answer 55

Gut, milk

Question 56

IgA1 is more prevalent in ___ and IgA2 is more prevalent in the ___

Answer 56

Serum, secretion

Question 57

IgA1 function can stimulate phagocytosis, granulation, and can neutralize toxins

Question 58

IgA1 don’t fix compliment, thus they don’t drive inflammation

Question 59

IgA is ___ resistant

Answer 59

Protease

Question 60

IgE can cause the release of ___

Answer 60

Histamine

Question 61

IgD stimulates basophils and mast cells to promote AMPs

Question 62

IgD is present is higher levels in the upper respiratory tract