E2: L18

Question 1

The IgG antibody is involved in 5/6 antibody-mediated effector functions. Which ones are they?

Answer 1

Neutralization, Agglutination, Opsonization, Complement activation, and ADCC

Question 2

Name the 6 antibody-mediated effector functions.
NOAADC

Answer 2

Neutralization, Opsonization, Agglutination, ADCC, and Degranulation, Complement activation

Question 3

The IgA antibody is involved in 2/6 antibody-mediated effector functions. Which ones are they? NC

Answer 3

Neutralization and Complement activation

Question 4

The FC receptor is the part of the antibody that is the base of the Y and remind __

Answer 4

constant

Question 5

epitope is the __ part of the molecule that fits with the ___

Answer 5

antigenic, paratrope

Question 6

The IgM antibody is involved in 5/6 antibody-mediated effector functions. Which ones are they?: NAOCA

Answer 6

Neutralization, Agglutination, Opsonization, Complement activation, and ADCC

Question 7

ADCC is ____ through cells that are stimulated to do so.

Answer 7

apoptosis

Question 8

___ is apoptosis through cells that are stimulated to do so.

Answer 8

ADCC

Question 9

IgE is invloed in 1/6 antibody-mediated functions. Which one is it?

Answer 9

Degranulation

Question 10

antibodies can bind in __ and __ regions

Answer 10

variable, constant

Question 11

Fc receptors mediate the ___ ___ of antibodies that bind to the Fc regions of antibodies.

Answer 11

receptor functions

Question 12

____ receptors are the bridge between innate and adaptive

Answer 12

Fc

Question 13

____ receptors on epithelial cells are used to take IgA from blood and put on surface of musoca to protect it. this is called ___

Answer 13

Fc, transmicrosis

Question 14

Fc receptors are members of the ___ superfamily

Answer 14

Immunoglobulin

Question 15

using Fc Receptors allows for __-__ immune cells and bridges the cellular and __ immune systems

Answer 15

non-specific, humoral

Question 16

Multiple FcRs (blue) need to be accessory ___ (green) to initiate a signal.

Answer 16

polypeptides

Question 17

The FcR signal may be positive (___ effector function) or negative (____ effector function).

Answer 17

enhancing, inhibiting

Question 18

The signal may be ____ (enhancing effector function) or ___ (inhibiting effector function).

Answer 18

positive, negative

Question 19

the ___ receptor of the ___ chain is where you bind to the Fc receptor.

Answer 19

constant, heavy

Question 20

1st class of Fc-gamma receptors bind to which Ig

Answer 20

IgG

Question 21

main mediators of antibody function in the body is done by Fc - ____

Answer 21

Fc-gamma

Question 22

name few cells that express the Fc-gamma receptor? MGN

Answer 22

macrophages, granulocytes, NK cells

Question 23

Fc-gamma is the main mediator of antibody function in the body because it binds to what Ig

Answer 23

IgG

Question 24

activating and inhibiting gamma-receptors that will induce what 3 things

Answer 24

phagocytosis, degranulation, ADCC

Question 25

the gamma receptor can induce phagocytosis if expressed by what cell

Answer 25

macrophage

Question 26

the gamma receptor can induce degranulation if expressed by what cell

Answer 26

granulocytes

Question 27

the gamma receptor can induce ADCC if expressed by what cell

Answer 27

NK Cells

Question 28

IgE has two subtypes on FcR receptors. they are most commonly associated with ___ symptoms

Answer 28

allergy

Question 29

upon exposure to an allergen, it causes the ___ cell to produce IgE antibodies

Answer 29

plasma

Question 30

upon exposure to an allergen, it causes the plasma cell to produce ___ antibodies

Answer 30

IgE

Question 31

FcR-IgA are expressed by a variety of ___ cell lines

Answer 31

myeloid

Question 32

myeloid cells include the following 4 cells: MMGD

Answer 32

monocytes, macrophages, granulocytes, dendritic cells

Question 33

serum IgA is slightly different than IgA bound to the tissues.

Answer 33

inhibitory

Question 34

Fc-IgA Contributes to pathogen destruction by triggering ___ and ___.

Answer 34

ADCC and phagocytosis

Question 35

ADCC stands for

Answer 35

Antibody dependent cellular cytotoxicity

Question 36

FcuR is expressed by what cell

Answer 36

neutrophils

Question 37

FcuR has a higher affinity for which Ig

Answer 37

IgM

Question 38

polyIgRecepotor can respond to ___ antibody types, expressed by ___ cells

Answer 38

multiple, epithelial

Question 39

name of the FcRn

Answer 39

neonatal Fc Receptor

Question 40

FcRn is related to what MHC class

Answer 40

1

Question 41

Which is the most diverse group of Fc receptors? A. PolyIgR B. FcγR C. FcRn D. FcεR E. Fcα/µR

Answer 41

B

Question 42

___ cells encounter Ag, bind it, and become activated.

Answer 42

B

Question 43

After receiving T-cell help, B cells differentiate into ____-___ plasma cells.

Answer 43

Antibody-secreting

Question 44

TCRs, BCRs, FcRs, MHC molecules belong to the ___ superfamily

Answer 44

immunoglobulin

Question 45

Fc–Fcγ receptor (FcγR) interactions drive pleiotropic effector functions that limit viral ___ and provide potent antiviral ___

Answer 45

replication, protection

Question 46

Ab bind Fc receptors expressed by other immune cells or epithelial/endothelial cells is an Immune ___ response

Answer 46

effector

Question 47

the immune effector response contains B or T cells?

Answer 47

B

Question 48

TCRs can't bind to antibodies directly; Ag must be presented on MHC molecule. ___ molecules are required for cell signaling

Answer 48

CD3

Question 49

antigen receptors of B and T lymphocytes are made from distinct sets of proteins but are similarly constructed. this is because they the same gene has undergone ___

Answer 49

recombination

Question 50

___-___ enhance TCR signal

Answer 50

Co-receptors

Question 51

Some receptors of this cell inhibit cellular response

Answer 51

lymphocyte