Enalaprilat Flashcards Preview

Yomata Drugs > Enalaprilat > Flashcards

Flashcards in Enalaprilat Deck (12):
1

Trade name

Vasotec

2

Class

Cardiosvacular agent; Antihypertensive/ACE inhibitor

3

Mechanism of Action

Angiotensin-converting enzyme (ACE) catalyzes the conversion of Angiotensin 1 to angiotensin II, which is a potent vasoconstrictive substance. As such, the inhibition of ACE by this drug decreases levels of angiotensin II, which leads to a drop in blood pressure from inhibited vasoconstrictive stimulation. It is also known to lower the pulmonary capillary wedge pressure (PCWP)

4

Indication

Used in management of mild to moderate hypertension. this drug can be used in combination therapy for CHF or in acute myocardial infarction because the drugs effects deviser both preload and after load to the heart

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Contraindications/ Precautions

Pregnancy; history of angioedema related to previous treatment with an ACE inhibitor; pre-existing hypotension; cariogenic shock' know hypersensitivity to ACE inhibitors

6

Adverse effects

Hypotension or postural hypotension. The patient may also experience reflexive tachycardia with heart palpitations. Patient may display angioedema, nausea. committing, alterations in kidney function and hyperkalemia

7

Routes of admin

IV

8

Onset of Action

Onset within 1 hour, peak 4-6 hrs, duration at least 24hrs

9

Adult dose

1.25 mg, ivp

10

Pediatric dose

Not indicated

11

Special considerations

Use cautiously with patients with renal impairment or renal artery stenosis, on diuretic therapy, or undergoing dialysis
Monitor blood pressure and cardiac rhythm closely
Serial lab values should be monitored closely so that potassium levels can be watched for hyperkalemia

12

Protocols used

A-5 Chest pain
A-6 CHF
A-6b CPAP