Flashcards in ENDOCRINE SYSTEM Deck (151)
what causes cushing's syndrome?
over production of glucocorticoids
long term corticosteroid treatment e.g. autoimmune/inflamm
what causes 90% of cushings cases?
ACTH over production from pituitary gland & adrenal hyperplasia
where in the body except the pituitary can ACTH be produced?
Ectopic ACTH production due to tumour formation ( benign and malignant)
Lung= small cell lung cancer
what 5 things make up Carney Complex ?
Multiple Endocrine Neoplasia (men)
what is the point of an overnight dexamethasone suppression test in the diagnosis of Cushing's?
giving body steroids should cause serum levels to decrease in a normal patient. If don't can be cushings
why might you suggest a CT/MRI in the diagnosis of Cushing's?
of adrenal glands to check for hyperplasia
give 2 types of weight gain that are characteristic of Cushing's
give 2 skin symptoms of Cushing's
purple abdominal striae
thin bruising skin
poor wound healing
give two genitor-reproductive symptoms of Cushing's
give 2 bone symptoms of Cushing's
what is hirtuism? (symptom of Cushing's)
hair growth on face
give 2 drugs that can be given in treatment of Cushing's by decreasing plasma cortisol
excess of what can cause pseudo-cushings?
which gender is thyroid problems most common in?
what causes 2/3 of hyperthyroidism?
what causes Grave's disease?
IgG antibodies bind to TRH receptors and cause excess hormone and thyroid hyperplaseia
give 3 triggers of grave's
what other conditions is Grave's associated with?
Addisons, DMT1 and Vitiligo
give 4 other causes of hyperthyroidism
toxic multi nodular goitre
toxic adenoma of thyroid gland
sub acute (de-quervain's) thyroiditis (self limiting)
choriocarcinoma (ocarina teratoma w thyroid tissue)
Out of these 3 hormone,TSH/T3/T4 which would be low and which would be high in hyperthyroidism?
high T3, T4
give 3 symptoms characteristic of Grave's disease
what is a risk of thyroidectomy surgery?
recurrent laryngeal nerve damage
give 5 complications of hyperthyroidism
thyroid eye disease
what is hashimoto's thyroiditis?
autoimmune destruction of thyroid gland
give 2 drugs which can cause hypothyroidism
Name 2 genetic syndromes that can cause hypothyroidism
what is pendred's syndrome?
thyroid problems & bilateral sensorineural deafness
what is Turner's syndrome?
female missing one sex chromosome (45X)
what is the cause of secondary hypothyroidism?