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Y3 CORE CONDITIONS > ENDOCRINE SYSTEM > Flashcards

Flashcards in ENDOCRINE SYSTEM Deck (151)
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31

what causes cushing's syndrome?

hyperadrenocorticolism
over production of glucocorticoids
long term corticosteroid treatment e.g. autoimmune/inflamm
adrenal carcinoma/adenoma
Carney Complex
Cushings disease

32

what causes 90% of cushings cases?

ACTH over production from pituitary gland & adrenal hyperplasia

33

where in the body except the pituitary can ACTH be produced?

Ectopic ACTH production due to tumour formation ( benign and malignant)
Thyroid
Lung= small cell lung cancer
Pancreas
Thymus glands

34

what 5 things make up Carney Complex ?
Multiple Endocrine Neoplasia (men)

adrenal hyperplasia
pituitary adenoma
myopia
schwannoma
testicular tumour

35

what is the point of an overnight dexamethasone suppression test in the diagnosis of Cushing's?

giving body steroids should cause serum levels to decrease in a normal patient. If don't can be cushings

36

why might you suggest a CT/MRI in the diagnosis of Cushing's?

of adrenal glands to check for hyperplasia

37

give 2 types of weight gain that are characteristic of Cushing's

central obesity
moon face

38

give 2 skin symptoms of Cushing's

purple abdominal striae
thin bruising skin
poor wound healing

39

give two genitor-reproductive symptoms of Cushing's

amenorrhoea
impotence
libido loss

40

give 2 bone symptoms of Cushing's

osteoporosis
fractures

41

what is hirtuism? (symptom of Cushing's)

hair growth on face

42

give 2 drugs that can be given in treatment of Cushing's by decreasing plasma cortisol

aminoglutethimide
ketoconazole
metyrapone

43

excess of what can cause pseudo-cushings?

alcohol

44

which gender is thyroid problems most common in?

females

45

what causes 2/3 of hyperthyroidism?

grave's disease

46

what causes Grave's disease?

IgG antibodies bind to TRH receptors and cause excess hormone and thyroid hyperplaseia

47

give 3 triggers of grave's

infection
stress
childbirth

48

what other conditions is Grave's associated with?

Addisons, DMT1 and Vitiligo

49

give 4 other causes of hyperthyroidism

toxic multi nodular goitre
toxic adenoma of thyroid gland
follicular carcinoma
sub acute (de-quervain's) thyroiditis (self limiting)
choriocarcinoma (ocarina teratoma w thyroid tissue)

50

Out of these 3 hormone,TSH/T3/T4 which would be low and which would be high in hyperthyroidism?

low TSH
high T3, T4

51

give 3 symptoms characteristic of Grave's disease

exophthalmus
pretibial myxoedema
thyroid acropatchy
thyroid bruis
Clubbing

52

what is a risk of thyroidectomy surgery?

recurrent laryngeal nerve damage

53

give 5 complications of hyperthyroidism

HF
Atrial fibrillation
thyroid eye disease
osteoporosis
gynaecomastia

54

what is hashimoto's thyroiditis?

autoimmune destruction of thyroid gland

55

give 2 drugs which can cause hypothyroidism

amiodarone
lithium
iodine
carbimazole

56

Name 2 genetic syndromes that can cause hypothyroidism

Pended's
Turner's

57

what is pendred's syndrome?

thyroid problems & bilateral sensorineural deafness

58

what is Turner's syndrome?

female missing one sex chromosome (45X)

59

what is the cause of secondary hypothyroidism?

pituitary failure

60

which of these indicates thyroid failure and which indicates pituitary failure?
a) high TSH, low T3/4
b) low TSH, low T3/4

a) thyroid failure
b) pituitary failure