Fatty Acid Synthesis Flashcards Preview

MCP > Fatty Acid Synthesis > Flashcards

Flashcards in Fatty Acid Synthesis Deck (74)
Loading flashcards...
31

condensation step

Malonyl CoA attaches to the ____ part of the ACP of FAS

phosphopantetheinyl (P) 

32

step 2: condensation

after acetyl group from acetyl Coa first associates with the ACP phospho-pantetheinyl sulfhydryl group, it is then 

transferred to the cysteine sulfhydryl of the other subunit.

33

after acetyl group from acetyl coa associated with ACP sulfhydryl group. what happens? 

Malonyl from malonyl CoA then associates with the ACP phospho-pantetheinyl sulfhydryl group.

34

step 2: condensation

The acetyl and malonyl groups condense with release of the malonyl carboxyl group as

CO2

35

step 2: condensation

after coa2 is released by condensation, ___ is created

4C  β−keto acyl chain which is attached to the ACP phospho-pantetheinyl sulfhydryl group.

 

* will eventually become the omega methyl group of palmitate is labelled ω.

36

step 3: 

n Fatty Acid Synthesis include a reduction of the β−keto group to an___

 alcohol 

37

step 4

 dehydration to form a ____

double bond

38

step 5

another reduction step reduces the_____

 double bond.

39

in fa synthesis, NADPH provides the reducing equivalents for what steps

step 3 -- reduing b-keto group --> alcohol

step 5 -- reducing double bound

40

steps 2-5 are repeated with the result being a ___

6C fatty acyl chain

41

after stepes 2-5 make 6C fatty acyl chain, the series of reactions is repeated until 

he fatty acid chain is 16 carbons

42

after the he fatty acid chain is 16 carbons then 

hydrolysis occurs and palmitate is released.

43

after palmitiate si reelased from fAS it is activated to

palmitoyl coa

44

palmityl coa and other long chain fatty acyl coas can be elongated ___ carbons at a time

two

45

where are fa chains elongated? by what enzymes?

in the er

by elongases

46

difference between steps in elongation and synrhsis of fa?

the long fatty acid is attached to coenzyme A instead of a phophopanthetinyl residue

47

Desaturation is the oxidation of fatty acids resulting in 

cis double bonds.

48

____ of FA creates lipids of increasing structural and functional complexity with
distinct biological roles.

Desaturation 

49

what does fa desaturation require? where is it found

desaturases, found in the er

50

what do desaturases require

o2

nadh

cytochrome b5 (where electrons pass through)

51

During starvation, desaturase activities

 decrease sharply

52

desaturase ___ upon feeding with carbohydrate.

increases

53

When large amounts of ____ are eaten desaturase activities decrease.

unsaturated fats

54

Humans have what three distinct Desaturases distinguished by the position of the double bond insertion within the fatty acid chain.

Ø Δ9 desaturase
Ø Δ6 desaturase
Ø Δ5 desaturase

55

The most common desaturation reactions involve an
oxidation leading to a double bond between ___

C9 and C10.

56

what is required for  eicosinoid synthesis.

polyunusaturated FAs with double bonds 3 C s(ω3) o r6 carbons (ω6) from the methyl end 

57

We do not synthesize the____ fatty acids de novo so they must come from our diet

 ω3 and ω6

58

 linoleic  and linolenic fatty acids primarily from plant oils help prodvide  

ω3 and ω6 fatty acids, since we do not syntehsis these de novo

59

importance of arachidonic acid?

- PRECURSOR OF SEVERAL EICOSANOIDS

- IMPORTANT COMPONENT OF MEMBRANE LIPIDS

60

Linoleic acid can be converted by elongation and desaturation reactions to ___

arachidonic acid