is Arachidonic acid an essential fa?
not if lioleic acid is present since that can syntehsize it
____ is a susbtrate for leukotrienes, thromboxanes, prostaglandins
Eicosanoids include the (3)
prostaglandins, thromboxanes and leukotrienes
Eicosanoids tend to be unstable and ahve very __ biological half life
what are the three pathways that metabolize arachidonic acid
1. via cycloxgenase -- forms the prostaglandins, thromboxanes and prostacyclins;
2. via lipoxygenase -- forms leukotrienes, hydroxyeicosatetraenoic acids (HETEs), and lipoxins
3. via cytochrome p50 -- forms epoxides.
the cyclic (or cyclooxygenase) pathway of eicosanoids syntheis forms the (3)
thromboxanes and prostacyclins;
the linear (or lipoxygenase) pathway of eicosanoid synthesis forms
--> HPETE ----> leukotrienes, lipoxins, HETEs
the cytochrome P450 pathway of eicosanoid synthesis forms ___.
(aspirin and other NSAIDs act on ____
cyclooxygenase (which converts converts arachidonic acid to PGH2)
cyclooxygenase converts __ to ___
arachidonic acid to PGH2
cyclooxygenase___ is tjhe form expressed in all tisues
cyclooxygenase___ is tjhe form regulated by cytokines and growth factors.
it is inc in inflamattion
___ is an irreversible inhbiitor of cox-1 and cox-2
___ is an reverisible inhbiitor of cox-1 and cox-2
acetaminophen and ibuprofen