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Flashcards in Fatty Acid Synthesis Deck (74)
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61

is Arachidonic acid an essential fa?

not if lioleic acid is present since that can syntehsize it

62

____ is a susbtrate for leukotrienes, thromboxanes, prostaglandins

arachidonic acid

63

Eicosanoids include the (3)

prostaglandins, thromboxanes and leukotrienes

64

Eicosanoids tend to be unstable and ahve very __ biological half life

short

65

what are the three pathways that metabolize arachidonic acid

1. via cycloxgenase -- forms the prostaglandins, thromboxanes and prostacyclins;

2. via lipoxygenase -- forms  leukotrienes, hydroxyeicosatetraenoic acids (HETEs), and lipoxins

3. via cytochrome p50 -- forms epoxides.

66

the cyclic (or cyclooxygenase) pathway of eicosanoids syntheis forms the (3)

 prostaglandins,
thromboxanes and prostacyclins;

67

the linear (or lipoxygenase) pathway of eicosanoid synthesis forms

--> HPETE ----> leukotrienes, lipoxins, HETEs

68

the cytochrome P450 pathway of eicosanoid synthesis forms ___.

epoxides

69

(aspirin and other NSAIDs act on ____ 

cyclooxygenase (which converts converts arachidonic acid to PGH2)

70

 cyclooxygenase converts __ to ___

arachidonic acid to PGH2

71

cyclooxygenase___ is tjhe form expressed in all tisues

cox-1

72

cyclooxygenase___ is tjhe form regulated by cytokines and growth factors.

 

it is inc in inflamattion

cox-2

73

___ is an irreversible inhbiitor of cox-1 and cox-2

aspirin

74

___ is an reverisible inhbiitor of cox-1 and cox-2

acetaminophen and ibuprofen