First Aid - Pathology - Tumor Associations Flashcards Preview

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Flashcards in First Aid - Pathology - Tumor Associations Deck (90)
1

acanthosis nigricans

visceral malignancy

2

actinic keratosis

SCC of skin

3

AIDS

aggressive malignant lymphomas (non-Hodgkin) and Kaposi sarcoma

4

AI diseases (Hashimoto's, SLE)

Lymphoma

5

Barrett's

esophageal adenocarcinoma

6

chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

gastric adenocarcinoma

7

cirrhosis

HCC

8

Cushing syndrome

small cell lung cancer

9

Dermatomyositis

lung cancer

10

down syndrome

ALL AML

11

dysplastic nevus

malignant melanoma

12

hypercalcemia

squamous cell lung cancer

13

immunodeficiency states

malignant lymphomas

14

Lambert-Eaton myasthenic syndrome

small cell lung cancer

15

myasthenia gravis, pure RBC aplasia

thymoma

16

paget's disease of bone

secondary osteosarcoma and fibrosarcoma

17

plummer-vinson syndrome (dec. iron)

squamous cell carcinoma of esophagus

18

polycythemia

renal cell carcinoma, HCC

19

radiation exposure

leukemia, sarcoma, papillary thyroid cancer and breast cancer

20

SIADH

small cell lung cancer

21

Tuberous sclerosis (facial angiofibroma, seizures, intellectual disability)

giant cell astrocytoma, renal angiomyolipoma, and cardiac rhabdomyoma

22

ulcerative colitis

colonic adenocarcinoma

23

xeroderma pigmentosa, albinism

melanoma, basal cell carcinoma, SCC of skin

24

oncogenes

BCR-ABL, bcl2, BRAF, c-kit, c-myc, HER2/neu, L-myc, N-myc, ras, ret

25

BCR-ABL

CML, ALL

26

bcl2

follicular and undifferentiated lymphomas

27

BRAF

melanoma

28

c-kit

GI stromal tumor

29

c-myc

Burkitt lymphoma

30

HER2/neu

breast, ovarian and gastric carcinoma

31

L-myc

lung tumor

32

N-myc

neuroblastoma

33

ras

colon cancer, lung cancer and pancreatic cancer

34

ret

MEN2A and 2B

35

tumor suppressor genes

APC, BRCA1, BRCA2, CPD4/SMAD4, DCC, MEN1, NF1, NF2, p16, p53, PTEN, Rb, TSC1, TSC2, VHL, WT1, WT2

36

APC

colorectal cancer (FAP)

37

BRCA1

breast and ovarian cancer in women

38

BRCA2

breast in men

39

CPD4/SMAD4

pancreatic cancer

40

DCC

colon cancer

41

MEN1

MEN type 1

42

NF1/NF2

neurofibromatosis 1/2

43

p16

melanoma

44

p53

most cancers, li-fraumani syndrome

45

PTEN

breast cancer, prostate cancer, endometrial cancer

46

Rb

retinoblastoma, sarcoma

47

TSC1/2

tuberous sclerosis

48

VHL

von-hippel lindau disease

49

WT1/2

Wilm's tumor

50

tumor markers

ALP, aFP, b-hCG, CA15-3, CA27-29, CA19-9, CA125, calcitonin, CEA, PSA, S100, TRAP

51

ALP

metastases to bone, liber, paget's disease of bone, seminoma (placental ALP)

52

aFP

HCC, hepatoblastoma, yolk sac tumor, testicular cancer, mixed germ cell tumor

53

b-hCG

hydatidiform moles and choriocarcinomas, testicular cancer

54

CA-15-3

breast cancer

55

CA-27-29

breast cancer

56

CA-19-9

pancreatic adenocarcinoma

57

CA-125

ovarian cancer

58

calcitonin

medullary thyroid carcinoma

59

CEA

nonspecific! Colorectal, pancreatic, gastric, breast and medullary thyroid carcinomas

60

PSA

prostate adenocarcinoma, but also BPH and prostatitis

61

S100

neural creast origin: melanomas, neural tumors, schwannomas, langerhans cell histiocytosis

62

TRAP

hairy cell leukemia - b cell neoplasm

63

EBV

burkitt lymphoma, hodgkin lymphoma, nasopharyngeal carcinoma, CNS lymphoma

64

HBV, HCV

HCC

65

HHV8

kaposi sarcoma, body cavity fluid B-cell lymphoma

66

HPV

cervical and penile/anal carcinoma, head, neck and throat cancer

67

H. pylori

gastric adenocarcinoma

68

HTLV1

adult t-cell leukemia/lymphoma

69

Liver fluke

cholangiocarcinoma

70

schistosoma haematobium

bladder cancer (squamous cell

71

oncogenic microbes

EBV, HBV, HCV, HHV8, HPV, H. pylori, HTLV1, Liver fluke, Shistosoma

72

aflatoxins

HCC

73

alkylating agents

leukemia, lymphoma

74

aromatic amines

transitional cell carcinoma

75

arsenic

angiosarcoma (liver), lung cancer, SCC of skin

76

asbestos

bronchogenic carcinoma > mesothelioma

77

carbon tetrachloride

centrilobular necrosis, fatty change (liver)

78

cigarette smoke

transitional cell carcinoma (bladder), SCC and adenocarcinoma (esophagus), renal cell carcinoma, SCC of larynx, squamous cell and small cell carcinoma of lun, pancreatic adenocarcinoma

79

ethanol

HCC

80

ionizing radiation

papillary thyroid carcinoma

81

nitrosamines

gastric cancer

82

radon

lung cancer

83

vinyl chloride

angiosarcoma of liver

84

1,25-(OH)2 D3 (calcitriol)

hodgkin lymphoma, some non-Hodgkin lymphomas

85

ACTH

small cell lung carcinoma

86

ADH

small cell lung carcinoma and intracranial neoplasms

87

Abs against presynaptic CA2+ channels at NMJ

small cell lung carcinoma

88

Erythropoietin

renal cell carcinoma, thymoma, hemangioblastoma, HCC, leiomyoma, pheochromocytoma

89

PTHrP

Squamous cell lung carcinoma, renal cell carcinoma, breast cancer

90

Psammoma bodies

papillary carcinoma of thyroid, serous papillary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma