First Aid - Pathology - Tumor Associations Flashcards by d k

acanthosis nigricans

visceral malignancy

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actinic keratosis

SCC of skin

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AIDS

aggressive malignant lymphomas (non-Hodgkin) and Kaposi sarcoma

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AI diseases (Hashimoto’s, SLE)

Lymphoma

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Barrett’s

esophageal adenocarcinoma

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chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

gastric adenocarcinoma

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cirrhosis

HCC

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Cushing syndrome

small cell lung cancer

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Dermatomyositis

lung cancer

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down syndrome

ALL AML

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dysplastic nevus

malignant melanoma

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hypercalcemia

squamous cell lung cancer

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immunodeficiency states

malignant lymphomas

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Lambert-Eaton myasthenic syndrome

small cell lung cancer

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myasthenia gravis, pure RBC aplasia

thymoma

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paget’s disease of bone

secondary osteosarcoma and fibrosarcoma

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plummer-vinson syndrome (dec. iron)

squamous cell carcinoma of esophagus

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polycythemia

renal cell carcinoma, HCC

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radiation exposure

leukemia, sarcoma, papillary thyroid cancer and breast cancer

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SIADH

small cell lung cancer

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Tuberous sclerosis (facial angiofibroma, seizures, intellectual disability)

giant cell astrocytoma, renal angiomyolipoma, and cardiac rhabdomyoma

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ulcerative colitis

colonic adenocarcinoma

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xeroderma pigmentosa, albinism

melanoma, basal cell carcinoma, SCC of skin

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oncogenes

BCR-ABL, bcl2, BRAF, c-kit, c-myc, HER2/neu, L-myc, N-myc, ras, ret

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BCR-ABL

CML, ALL

bcl2

follicular and undifferentiated lymphomas

BRAF

melanoma

c-kit

GI stromal tumor

c-myc

Burkitt lymphoma

HER2/neu

breast, ovarian and gastric carcinoma

L-myc

lung tumor

N-myc

neuroblastoma

ras

colon cancer, lung cancer and pancreatic cancer

ret

MEN2A and 2B

tumor suppressor genes

APC, BRCA1, BRCA2, CPD4/SMAD4, DCC, MEN1, NF1, NF2, p16, p53, PTEN, Rb, TSC1, TSC2, VHL, WT1, WT2

APC

colorectal cancer (FAP)

BRCA1

breast and ovarian cancer in women

BRCA2

breast in men

CPD4/SMAD4

pancreatic cancer

DCC

colon cancer

MEN1

MEN type 1

NF1/NF2

neurofibromatosis 1/2

p16

melanoma

p53

most cancers, li-fraumani syndrome

PTEN

breast cancer, prostate cancer, endometrial cancer

retinoblastoma, sarcoma

TSC1/2

tuberous sclerosis

VHL

von-hippel lindau disease

WT1/2

Wilm's tumor

tumor markers

ALP, aFP, b-hCG, CA15-3, CA27-29, CA19-9, CA125, calcitonin, CEA, PSA, S100, TRAP

ALP

metastases to bone, liber, paget's disease of bone, seminoma (placental ALP)

aFP

HCC, hepatoblastoma, yolk sac tumor, testicular cancer, mixed germ cell tumor

b-hCG

hydatidiform moles and choriocarcinomas, testicular cancer

CA-15-3

breast cancer

CA-27-29

breast cancer

CA-19-9

pancreatic adenocarcinoma

CA-125

ovarian cancer

calcitonin

medullary thyroid carcinoma

CEA

nonspecific! Colorectal, pancreatic, gastric, breast and medullary thyroid carcinomas

PSA

prostate adenocarcinoma, but also BPH and prostatitis

S100

neural creast origin: melanomas, neural tumors, schwannomas, langerhans cell histiocytosis

TRAP

hairy cell leukemia - b cell neoplasm

EBV

burkitt lymphoma, hodgkin lymphoma, nasopharyngeal carcinoma, CNS lymphoma

HBV, HCV

HCC

HHV8

kaposi sarcoma, body cavity fluid B-cell lymphoma

HPV

cervical and penile/anal carcinoma, head, neck and throat cancer

H. pylori

gastric adenocarcinoma

HTLV1

adult t-cell leukemia/lymphoma

Liver fluke

cholangiocarcinoma

schistosoma haematobium

bladder cancer (squamous cell

oncogenic microbes

EBV, HBV, HCV, HHV8, HPV, H. pylori, HTLV1, Liver fluke, Shistosoma

aflatoxins

HCC

alkylating agents

leukemia, lymphoma

aromatic amines

transitional cell carcinoma

arsenic

angiosarcoma (liver), lung cancer, SCC of skin

asbestos

bronchogenic carcinoma > mesothelioma

carbon tetrachloride

centrilobular necrosis, fatty change (liver)

cigarette smoke

transitional cell carcinoma (bladder), SCC and adenocarcinoma (esophagus), renal cell carcinoma, SCC of larynx, squamous cell and small cell carcinoma of lun, pancreatic adenocarcinoma

ethanol

HCC

ionizing radiation

papillary thyroid carcinoma

nitrosamines

gastric cancer

radon

lung cancer

vinyl chloride

angiosarcoma of liver

1,25-(OH)2 D3 (calcitriol)

hodgkin lymphoma, some non-Hodgkin lymphomas

ACTH

small cell lung carcinoma

ADH

small cell lung carcinoma and intracranial neoplasms

Abs against presynaptic CA2+ channels at NMJ

small cell lung carcinoma

Erythropoietin

renal cell carcinoma, thymoma, hemangioblastoma, HCC, leiomyoma, pheochromocytoma

PTHrP

Squamous cell lung carcinoma, renal cell carcinoma, breast cancer

Psammoma bodies

papillary carcinoma of thyroid, serous papillary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma

First Aid - Pathology - Tumor Associations Flashcards

(90 cards)