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Flashcards in Psych Pharm Deck (76)
1

Drugs for ADHD

Methylphenidate

2

Drugs for Alcohol withdrawal

benzos

3

Drugs for anxiety

SSRIs, SNRIs, buspirone

4

Drugs for bipolar

mood stabilizers: lithium, valproic acid, carbamazepine
atypical antipsychotics

5

Drugs for bulimia

SSRIs

6

Drugs for depression

SSRIs, SNRIs, TCAs, buproprion, mirtazapine (esp with insomnia)

7

Drugs for OCD

SSRIs, clomipramine

8

Drugs for panic d/o

SSRIs, venlafaxine, benzodiazepines

9

Drugs for PTSD

SSRIs

10

Drugs for schizophrenia

antipsychotics

11

Drugs for social phobias

SSRIs, beta-blockers

12

drugs for tourette syndrome

antipsychotics (haloperidol, risperidone)

13

CNS stimulants

methyl phenidate, desctroamphetamine, methamphetamine, phentermine

14

CNS stimulant MOA

inc. catecholamines (NE and DA esp) at synaptic cleft

15

CNS stimulant use

ADHD, narcolepsy, appetite control

16

Antipsychotics/ neuroleptics

haloperidol, trifluoperazine, fluphenazine, thioridazine, chlorpromazine

17

Antipsychotic MOA

block D2 receptors and increase cAMP

18

which anti psychotics have high potency

trifluoperazine, fluphenazine, haloperidol

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which antipsychotics have low potency

chlorpromazine, thiridazine

20

what side effects do you experience with high potency antipsychotics?

neurological (extrapyramidal SEs)

21

SE of low potency anti-psychotics

anticholinergic, antihistamine and a1 blockade effects

22

SE of chlorpromazine

corneal deposits

23

SE of thioridazine

retinal deposits

24

SE of haloperidol

NMS and tardive dyskinesia

25

clinical uses of antipsychotics

schizophrenia, psychosis, acute mania, tourettes

26

antipsychotics: lipid or water soluble?

highly lipid soluble

27

extrapyramidal side effects of antipsychotics? Treatment?

dyskinesia
benstropine or diphenhydramine

28

Endocrine SE of antipsychotics

DA antagonism leads to hyperprolactinemia and galactorrhea

29

SE of antipsychotics?

EPS - dyskinesia
endocrine - DA antag --> hyperprolactinemia, galactorrhea
muscarinic block --> dry mouth, constipation
a1 block --> hypotension
histamine block --> sedation
NMS
tardive dyskinesia

30

What is the evolution of EPS SE?

4hr: acute dystonia
4 day: akathisia (restless)
4 week: bradykinesia
4 month: tardive dyskinesa

31

What is neuroleptic malignant syndrome?

Fever, Encephalopathy, Vitals unstable, Enzymes increase, Rigidity of muscles

32

How do you treat NMS

dantroline, D2 agonists (bromocriptine)

33

what is tardive dyskinesia?

oral facial movements from long term antipsychotic use

34

What are the atypical antipsychotics?

olanzapine, clozapine, quetiapine, risperidone, aripiprazole

35

MOA of atypical antipsychotics?

unknown, varied 5HT2, DA, alpha and H1 R effects

36

what are the clinical uses of atypical antipsychotics?

schizophrenia, bipolar, OCD, anxiety, depression, mania, tourettes

37

what are the SE of olanzapine

weight gain

38

what are the SE of clozapine

weight gain
agranulocytosis

39

what are the SE of risperidone

increased prolactin causing decreased GnRH, LH and FSH

40

what are the SE of ziprasidone

prolonged QT

41

MOA of lithium

not established, maybe IP3 cascade

42

clinical use of lithium

mood stabilizer for bipolar, blocks relapse and acute manic events, SIADH

43

SE of lithium

tremor,sedation, edema, heart block, hypothyroid, polyuria, teratogenic

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How is lithium excreted

renally and reabsorved at PCT

45

MOA of buspirone

stimulates 5HT1A

46

clinical uses of buspirone

GAD (need 1 to 2 weeks), not sedative, addictive. Can take with EtOH

47

What are the SSRIs?

fluoxetine, paroxetine, sertraline, citalopram

48

MOA of SSRIs

5HT specific reuptake inhibitors

49

clinical uses of SSRIs

depression, GAD, Panic d/o, OCD, bulimia, social phobias, PTSD. Takes 4 - 8 weeks

50

what are the SE of SSRIs?

GI distress, sexual dysfunction.

51

what is serotonin syndrome?

increased 5HT can lead to hyperthermia, confusion, myoclonus, cardiovascular collapse, dlushing, diarrhea and seizures

52

how do you treat serotonin syndrome?

cyproheptadine which is a 5HT2 receptor antagonist

53

what are the SNRIs

venlafaxine, duloxetine

54

MOA of SNRIs

5HT and NE reuptake inhibitors

55

clinical use of SNRIs

depression, GAD, panic d/o, duloxetine also for diabetic peripheral neuropathy

56

what are the SE of SNRIs

increased BP, stimulant effects, sedation, nausea

57

what are the TCAs?

amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, doxepin, amoxapine

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MOA of TCAs

block reuptake of NE and 5HT

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clinical uses of TCAs

major depression, OCD (clomipramine), fibromyalgia

60

what are the SE of TCAs?

sedation
a1 blocking (postural hypoTN
atropine like effects (tachycardia, urinary retention, dry mouth)
convulsions, coma, cardiotoxicity, respiratory depression, hyperpyrexia, confusion

61

which TCA has more anticholinergic effects?

amitriptyline in comparison to nortriptyline

62

what are the SE of desipramine?

less sedating than other TCAs but higher seizure incidence

63

MAO inhibitors

tranylcypromine, phenelzine, isocarboxazid, selegiline

64

MOA of MAO inhibitors

increase NE, 5HT, and DA

65

clinical uses of MAO inhibitors

atypical depression, anxiety, hypochondriasis

66

SE of MAO inhibitors

hypertensive crisis (ingestion of tyramine: wine and cheese)
CNS stimulation

67

With what drugs are MAO inhibitors contraindicated and why?

SSRIs, TCAs, St. John's wort., meperidine, and dextromethorphan b/c of serotonin syndrome

68

clinical use of buproprion

smoking cessation

69

MOA of buproprion

unknown, but increase NE and DA

70

SE of buproprion

stimulant: tachycardia, insomnia
headache
seizure in bulimics

71

MOA of mirtazapine

a2 antagonist --> increase release of NE and 5HT
potent 5HT2 and 5HT3 receptor antagonist

72

SE of mirtazapine

sedation, increased appetite, weight gain, dry mouth

73

what are the atypical antidepressants?

bupropiion, mirtazapine, trazodone

74

MOA of trazadone

block 5HT2 and a1 receptors

75

clinical uses of trazadone

insomnia, high dose needed for antidepressent effects

76

SE of trazadone

sedation, nausea, priapism, postural hypotension