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Flashcards - Immuno

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1
Q

right lymphatic drainage

A

right side above diaphragm

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2
Q

IgA

A

Does not fix complement - monomer/dimer - excreted by transcytosis - protects against Giardia

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3
Q

Hypersensitivity Type I

A

allergy - analphylaxis/atopic, IgE - preformed Abs, on presensitized mast cells –> histamine release

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4
Q

Hypersensitivity Type II

A

tissue target - positive Coombs test - goodpastures, pernicious anemia, anti-Rh, graves

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5
Q

Hypersensitivity Type III

A

serum sickness, SLE/post strep glomerulonephritis - antigen/complement complex

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6
Q

Hypersensitivity Type IV

A

contact dermatitis, MS, PPD, Graft v Host - sensitized T-cell to antigen –> cytokine release

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7
Q

Thymus independent

A

antigens with no peptide component, cannot be presented by MHC - weak vaccines

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8
Q

Thymus dependent

A

antigens with protein component (diphtheria) - class switching and B-cell memory

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9
Q

Adenoside deaminase deficiency

A

SCID

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10
Q

Arthus reaction

A

Type III - after injections - ab/ag complexes form necrosis

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11
Q

MHC I chains

A

heavy chain + B2 microglobulin

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12
Q

MHC II chains

A

Alpha and beta polypeptide chains

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13
Q

Th2

A

mediate class switching and Ab production by B cells, recruits eosinophils - humoral immunity

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14
Q

HLA-A3

A

Hemochromatosis

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15
Q

HLA-B27

A

Ankylosing spondylitis, Reiter’s syndrome, Ulcerative colitis

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16
Q

HLA-DR2

A

SLE, Goodpasture, MS, hay fever

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17
Q

HLA-DR4

A

Rheumatoid Arthritis, Diabetes (DR3 as well)

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18
Q

HLA-DR5

A

pernicious anemia

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19
Q

HLA-DQ2/8

A

Celiac disease

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20
Q

IFN-a/b

A

modulates viral infections

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21
Q

IFN-gamma

A

Th1 - activates macrophages

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22
Q

IL-1

A

Macs - Fever, osteoclast activation

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23
Q

IL-2

A

T-cell - stimulates growth of helper, cytotoxic, regulatory T cells, NK cells

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24
Q

IL-3

A

T-cell - GM-CSF like factor

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25
IL-4
Th2 - mediates class-switch to IgE
26
IL-5
Th2 - attacts eosinophils, IgA production
27
IL-6
Macs - fever, induces production of acute phase reactants (hepcidin, CRP, ferritin, fibrinogen, serum amyloid A)
28
IL-8
Macs - chemoattractant for neutrophils
29
IL-10
Th2 - antiinflammatory - decreases MHC class II, Th1 cytokines
30
IL-12
Macs - stimulates differentiation into TH1 in naive T-helpers, NK cells stimulation
31
TNF-alpha
fever, hepatic release of acute-phase reactants, cachexia
32
TGF-beta
immunosuppresant
33
CD14
Macrophages - binds with TLR4 - involved in supertoxin response
34
CD18
LFA-1 integrin - defective in leukocyte adhesion deficiency type 1 - unable to extravasate
35
CD19
B-cells
36
CD20
B-cells - rituximab target
37
CD21
B-cell - EBV receptor
38
CD25
T-cells
39
CD28
T-cell - costimulation w/ B7 on dentritic cell activates T-cell --> cytokines
40
CD31
PECAM - neutrophil transmigration across endothelium
41
CD-40
B-cell - costimulation w/ CD40L on T-cell classwitches B-cell - defective in hyperIgM
42
CD54
ICAM - neutrophil adhesion
43
CD55
decay-accelerating factor (DAF) - inhibits complement activation on self cells
44
rituximab
Anti CD-20 - RA, B-cell lymphoma
45
muronamab
Anti CD-3 - expressed by activated T-lymphocytes - acute rejection
46
LTB4
chemoattractant neutrophils
47
C3a, C4a, C5a
anaphylaxis
48
C3b
opsonizes
49
C5a
neutrophil chemoattractant
50
C5b-9
cytolysis by MAC
51
NF-KB
transcription factor for cytokine production
52
isotype switching location
germinal center
53
tolerance development location
fetal thymus/peripheral
54
recombination location
bone marrow
55
negative selection location
fetal thymus medulla
56
Fas
expressed on T-lymphocytes - induces selfapoptosis, mutations result in autoimmune disease
57
FGFR3
AD - achondroplasia - impaired cartilage proliferation
58
Anti-ACh receptor
Myasthenia gravis
59
Anti-basement membrane
Goodpasture syndrome
60
Anticardiolipin, lupus anticoagulant
SLE, antiphospholipid syndrome
61
Anticentromere
Limited scleroderma (CREST syndrome)
62
Anti-desmosome (anti-desmoglein)
Pemphigus vulgaris
63
Anti-dsDNA, anti-Smith
SLE - dsDNA = renal disease, Smith = anti snRNPs
64
Anti-glutamic acid decarboxylase (GAD-65)
Type 1 diabetes mellitus
65
Antihemidesmosome
Bullous pemphigoid
66
Anti-histone
Drug-induced lupus - hydralazine, procainamide, isoniazid, minocycline, quinidine
67
Anti-Jo-1, anti-SRP, anti-Mi-2
Polymyositis, dermatomyositis
68
Antimicrosomal
Hashimoto thyroiditis
69
Antimitochondrial
1° biliary cirrhosis
70
Antinuclear antibodies
SLE, nonspecific
71
Antiparietal cell
Pernicious anemia
72
Anti-Scl-70 (anti-DNA topoisomerase I)
Scleroderma (diffuse)
73
Anti-smooth muscle
Autoimmune hepatitis
74
Anti-SSA, anti-SSB (anti-Ro, anti-La)
Sjögren syndrome
75
Anti-TSH receptor
Graves disease
76
Anti-U1 RNP (ribonucleoprotein)
Mixed connective tissue disease
77
IgA anti-endomysial, IgA anti-tissue transglutaminase
Celiac disease
78
MPO-ANCA/p-ANCA
Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strausssyndrome)
79
PR3-ANCA/c-ANCA
Granulomatosis with polyangiitis (Wegener)
80
Rheumatoid factor (IgM antibody that targets IgG Fc region), anti-CCP (more specific)
Rheumatoid arthritis
81
osteomyelitis in sickle cell
Salmonella, S. aureus
82
Pott disease
mycobacterium tuberculosis
83
rheumatoid arthritis hypersensitivity
Type III and IV
84
low C1 esterase inhibitor
heriditary angioedema - can't use ACE inhibitors
85
low C3
risk of recurrent pyogenic sinus/respiratory infections, type III reactions
86
C5-C9 deficiencies
recurrent Neisseria bacteremia
87
Bruton's agammaglobulinemia
BTK - bruton's tyrosine kinase deficiency - very low immunoglobulin, no mature B-cells, intact T-cell lymphocyte function, no lymph nodes/tonsils, germinal cortex absent - Giardia, enterovirus, bacteria, no vaccines
88
SCID
adenosine deanimase, IL-2R/cytokine defect or MHC II defect - unable to mature B and T-cells - complete absence of thymus, GCs and B/T cells
89
DiGeorge Syndrome
22q11 deletion - no thymus/parathymus - decreased T cells, hypocalcemia
90
Common variable immunodeficiency
B-cell maturation defect - decreased plasma cells and immunoglobulins - increased risk of autoimmune disease
91
IgA deficiency
decreased IgA, normal IgG/IgM - anaphylaxis to IgA containing blood
92
Hyper-IgM
CD40/CD40L defect - increased IgM due to inability to class switch - decreased IgE, IgA, IgG
93
Wiskott-Aldrich Syndrome
XL - WAS gene defect, unable to recognize actin cytoskeleton - WATER (Wiskott-Alrdich, thrombocytopenic purpura, eczema, recurrent infections)
94
Ataxia-teleangiectasia
ATM defect - DNA double strand repair - cerebellar defect, spider angiomas, IgA deficiency - increased AGP, decreased IgA, IgG, IgE, lymphopenia, cerebellar atrophy
95
Autosomal dominant hyper IgE
Deficiency of Th17 cells due to STAT3 mutation --> impaired neutrophil recruitment - coarse facies, cold staph abscesses, retained primary teeth, eczema, increased IgE, decreased IFN-gamma
96
IL-12 deficiency
AR - decreased Th1 response, IFN-gamma release - disseminated mycobacterial/fungal infections - no BCG vaccine
97
Chronic mucocutaneous candidiasis
T-cell dysfuction - no T-cell response to Candida antigens/infections
98
Chekiak-Higashi Syndrom
microtubule defect - unable to traffic phagosomes to lysosomes - pyogenic infections, albinism, neuropathy
99
CD3
T-cells
100
Leukotriene B4
neutrophil migration to site of inflammation
101
Th1
responsible for cell-mediated immune response against mycobacteria - activated by IL-12 from macs, and IFN-gamma from Th1
102
positive selection location
fetal thymus cortex
103
antithyroglobulin
Hashimotos

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