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1
Q

glomeruli-like pathology

A

Schiller-Duval bodies, yolk sac tumors

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2
Q

Reinke crystals

A

Leydig cell tumors - gynecomastia, precocious puberty - golden brown in color

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3
Q

fried egg

A

seminoma

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4
Q

granulosa cells arranged haphazardly around collections of eosinophilic fluid

A

Call-Exner bodies - granulosa cell tumors

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5
Q

koilocytes

A

condyloma - HPV 6/11

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6
Q

lower 1/3 of vagina drainage

A

urogenital sinus - inguinal nodes

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7
Q

upper 2/3 of vagina drainage

A

Mullerian ducts - regional iliac nodes

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8
Q

botryoides - bleeding grape like mass emerging from vagina - desmin/myogen+

A

embryonal rhabdomyosarcoma - affects girls under 4

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9
Q

high risk HPV

A

16, 18, 31, 33 - E6, E7 protein –> destruction p53 (BAX) and Rb (E2F)

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10
Q

low risk HPV

A

6, 11

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11
Q

acute endometritis abx

A

gentamicin + clindamysin +/- ampicillin

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12
Q

PCOS hormones

A

increased LH, decreased FSH, > 2:1

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13
Q

schiller-duval bodies (glomeruli), increased AFP

A

endodermal sinus tumor - yolk sac

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14
Q

large cells, clear cytoplasm

A

dysgerminoma

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15
Q

large primitive cells

A

ovarian/testicular - embryonal carcinoma -

testes: increased AFP, b-hCG

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16
Q

Reinke crystals

A

Sertoli-Leydig cells tumor - increased androgens

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17
Q

Kruckenberg tumor

A

metastatic gastric cancer - mucionous

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18
Q

pseudomyxoma peritonei

A

mucinous tumor of appendix

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19
Q

acute mastitis - bug/treatment

A

S. aureus/dicloxicillin

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20
Q

duct-like structures in a desmoplatin stroma, stellate infiltration, “rock hard”

A

invasive ductal carcinoma - most common (75%) worst and most invasion

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21
Q

decreased E-cadherins, Indian file cells, signet cell

A

invasive lobular cacinoma - multifocal - tx tamoxifen

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22
Q

Bowen disease

A

precursor SCC of penile shaft

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23
Q

Peyronie disease

A

fibrous plaque in tunica albuginea –> curved penis

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24
Q

cryptorchidism hormones

A

increased FSH, LH, decreaesed inhibin

25
proliferative endometrium
nonbranching, nonbudding uniform glands that are tubular, narrow and lined with pseudostratified elongated mitotically active epithelial cells
26
secretory endometrium
glycogen-rich mucus, edematous stroma, prominent spiral arteries
27
complete mole
46 XX or XY paternal - "bunch of grapes"
28
partial mole
69 XXX or XXY - normal villi and fetal tissue
29
mesonephric ducts
Wolffian ducts - forms male tract
30
paramesonephric ducts
Mullerian ducts - form female tract
31
PCOS infertility treatment
clomiphene - estrogen receptor modulator - decreases negative feedback inhibition of gonadotropin from hypothalamus
32
HER2/neu oncogene
encodes for intraceullar tyrosince kinase growth factor receptor
33
polycythemia vera mutation
V617F mutation with JAK2 - increased marrow sensitivity to EPO and TPO
34
theca interna cells
androgen synthesis - cholesterol to progesterone
35
granulosa cell
aromatase - androgens to estrogen
36
menopause marker
elevated FSH (no inhibition from estrogen)
37
infundibulopelvic ligament
holds ovaries to lateral pelvic wall - contains ovarian vessels
38
cardinal ligament
cervix to side wall of pelvis - contains uterine vessels
39
desmolase
enzyme to convert cholesterol to androgens - theca cell
40
arrest phase pre-ovulatoin
prophase I
41
arrest phase pre-fertilization
metaphase II
42
hCG production location
syncytiotrophoblast (outer layer of chorionic villi - low MHC I expression)
43
spermatogenesis
spermatogonium (2N, 2C) --> primary spermatocyte (2N, 4C) --> secondary spermatocyte (1N, 2C) --> spermatid haploid (1N,1C) --> spermatozoon haploid (1N,1C)
44
kallman syndrome
failure to complete puberty - hypogonadotropic hypogonandism - defective migration of GnRH cells and formation of olfactory bulbs - anosmia, infertility
45
placental abruption
abrupt, painful bleeding - cocaine, HTN, smoking
46
clear cell adenocarcinoma
DES exposure
47
looks like bladder, solid pale yellowtan/encapsulated tumor - "coffee bean" nuclei
Brenner tumor - benign tumor of ovary
48
meigs syndrome
triad of ovarian fibromas, ascites, hydrothorax - pulsing sensation in groin - spindle shaped fibroblasts
49
serous cystadenocarcinoma
most common ovarian neoplasm - psammoma bodies
50
adenomyosis treatment
GnRH agonists, hysterectomy
51
leaf-like projections - large bulky mass of connective tissue/cysts
Phyllodes tumor - malignant potential
52
small tumor in lactiferous ducts beneath areola - bloody nipple discharge
intraductal papilloma
53
comedocarcinoma
DCIS with central necrosis
54
Paget disease
from underlying DCIS - large cells in epidermis with clear halo
55
lichen sclerosis
thinning of epidermis, fibrosis of dermis (parchment) - increased risk of SCC
56
lichen simplex chronicus
hyperplasia of epithelium (thick leathery) - leukoplakia
57
endometrial carcninoma
hyperplastic: estrogen exposure - endometrioid histo sporadic: atrophic endometrium - serous/papillary/psammoma bodies
58
leiomyosarcoma
malignant - single lesion in uterus w/ areas of necrosis/hemorrhage

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