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Flashcards in GI Drugs Deck (77):
1

Cimetidine - use (3)

Peptic ulcer
Gastritis
Mild esophageal reflux

2

Ranitidine - use (3)

Peptic ulcer
Gastritis
Mild esophageal reflux

3

Famotidine - use (3)

Peptic ulcer
Gastritis
Mild esophageal reflux

4

Nizatidine - use (3)

Peptic ulcer
Gastritis
Mild esophageal reflux

5

Cimetidine - mech

H2 blocker - reversible block of histamine H2 receptors, decrease H+ secretion by parietal cells

6

Ranitidine - mech

H2 blocker - reversible block of histamine H2 receptors, decrease H+ secretion by parietal cells

7

Famotidine - mech

H2 blocker - reversible block of histamine H2 receptors, decrease H+ secretion by parietal cells

8

Ranitidine - side fx

Decreases renal excretion of creatinine

9

Cimetidine - side fx (4)

Decreases renal excretion of creatinine
Inhibits CYP-450
Antiandrogenic effects
Cross BBB (confusion, dizziness, headache) and placenta\

10

PPI - prazoles - mech

Irreversibly blocks the H/K ATPase in stomach parietal cells

11

PPI - prazoles - use (4)

Peptic ulcer
Gastritis
Esophageal reflux
Zollinger Ellison syndrome

12

PPI - prazoles - side fx

Increased risk of C. Diff infection & pneumonia
Decrease serum Mg long term

13

Bismuth - mech

Bind to ulcer base, providing physical protection and allowing HCO3 secretion to reestablish pH gradient in mucus layer

14

Bismuth - use (2)

Ulcer healing
Traveler's diarrhea

15

Sucralfate - mech

Bind to ulcer base, providing physical protection and allowing HCO3 secretion to reestablish pH gradient in mucus layer

16

Sucralfate - use (2)

Ulcer healing
Traveler's diarrhea

17

Misoprostol - mech (3)

PGE1 analog,
Increases production and secretion of the gastric mucous barrier
Decreases acid production

18

Misoprostol - use (3)

Prevention of NSAID-induced peptic ulcers (NSAID blocks PGE1)
Maintenance of PDA
Off label for labor induction

19

Misoprostol - side fx (2)

Diarrhea
Contraindicated in childbearing women

20

Octreotide - mech

Somatostatin analogue, long acting
Inhibits action of many splanchnic vasoconstriction hormones

21

Octreotide - use (4)

Acromegaly
Carcinoid syndrome
VIPoma
Esophageal variceal bleeding

22

Octreotide - side fx (3)

Nausea
Cramps
Steatorhhea

23

Sulfasalazine - use (2)

Ulcerative colitis
Crohn's Disease (colitis component)

24

Sulfasalazine - mech (2)

Combination of sulfapyridine (antibiotic) and 5-ASA (anti-inflammatory)
Activated by colonic bacteria

25

Sulfasalazine - side fx (4)

Malaise
Nausea
Sulfonamide toxicity
Reversible oligospermia

26

Ondansetron - mech (3)

5-HT3 antagonist
Decrease vagal stimulation
Powerful central acting anti-emetic

27

Ondansetron - clinical use

Control vomiting post-op and in patients undergoing cancer chemo

28

Ondansetron - side fx (3)

Headache
Constipation
QT interval prolongation

29

Metoclopramide - mech (3)

D2 receptor antagonist
Increases resting tone, contractility, LES tone, motility
Does not influence colon transport time

30

Metoclopramide - use (2)

Diabetic and postsurgery gastroparesis
Antiemetic

31

Metoclopramide - side fx

Parkinsonian effects & tardive dyskinesia
Restlessness, drowsiness, fatigue, depression, diarrhea
Drug interaction with digoxin and diabetic agents
Don't use in patients with small bowel obstruction or Parkinson disease

32

Orlistat - mech

Inhibits gastric and pancreatic lipase to decrease breakdown and absorption of dietary fats

33

Orlistat - use

Weight loss

34

Orlistat - side fx

Steatorrhea
Decreased absorption of fat-soluble vitamins

35

Peptic ulcer
Gastritis
Mild esophageal reflux

Cimetidine, Ranitidine, Famotidine, Nizatidine - use (3)

36

H2 blocker - reversible block of histamine H2 receptors, decrease H+ secretion by parietal cells

Cimetidine, Ranitidine, Famotidine, Nizatidine - mech

37

Decreases renal excretion of creatinine

Ranitidine - side fx

38

Decreases renal excretion of creatinine
Inhibits CYP-450
Antiandrogenic effects
Cross BBB (confusion, dizziness, headache) and placenta\

Cimetidine - side fx (4)

39

Irreversibly blocks the H/K ATPase in stomach parietal cells

PPI - prazoles - mech

40

Peptic ulcer
Gastritis
Esophageal reflux
Zollinger Ellison syndrome

PPI - prazoles - use (4)

41

Increased risk of C. Diff infection & pneumonia
Decrease serum Mg long term

PPI - prazoles - side fx

42

Bind to ulcer base, providing physical protection and allowing HCO3 secretion to reestablish pH gradient in mucus layer

Bismuth, Sucralfate - mech

43

Ulcer healing, Traveler's diarrhea

Bismuth, Sucralfate - use (2)

44

PGE1 analog,
Increases production and secretion of the gastric mucous barrier
Decreases acid production

Misoprostol - mech (3)

45

Prevention of NSAID-induced peptic ulcers (NSAID blocks PGE1)
Maintenance of PDAOff label for labor induction

Misoprostol - use (3)

46

Diarrhea
Contraindicated in childbearing women

Misoprostol - side fx (2)

47

Somatostatin analogue, long acting
Inhibits action of many splanchnic vasoconstriction hormones

Octreotide - mech

48

Acromegaly
Carcinoid syndrome
VIPoma
Esophageal variceal bleeding

Octreotide - use (4)

49

Nausea
Cramps
Steatorhhea

Octreotide - side fx (3)

50

Ulcerative colitis, Crohn's Disease (colitis component)

Sulfasalazine - use (2)

51

Combination of sulfapyridine (antibiotic) and 5-ASA (anti-inflammatory)
Activated by colonic bacteria

Sulfasalazine - mech (2)

52

Malaise,
Nausea,
Sulfonamide toxicity,
Reversible oligospermia

Sulfasalazine - side fx (4)

53

5-HT3 antagonist, Decrease vagal stimulation, Powerful central acting anti-emetic

Ondansetron - mech (3)

54

Control vomiting post-op and in patients undergoing cancer chemo

Ondansetron - clinical use

55

Headache
Constipation
QT interval prolongation

Ondansetron - side fx (3)

56

D2 receptor antagonist
Increases resting tone, contractility, LES tone, motility
Does not influence colon transport time

Metoclopramide - mech (3)

57

Diabetic and postsurgery gastroparesis
Antiemetic

Metoclopramide - use (2)

58

Parkinsonian effects & tardive dyskinesia
Restlessness, drowsiness, fatigue, depression, diarrhea
Drug interaction with digoxin and diabetic agents
Don't use in patients with small bowel obstruction or Parkinson disease

Metoclopramide - side fx

59

Inhibits gastric and pancreatic lipase to decrease breakdown and absorption of dietary fats

Orlistat - mech

60

Weight loss

Orlistat - use

61

Steatorrhea
Decreased absorption of fat-soluble vitamins

Orlistat - side fx

62

Magnesium hydroxide - mech

Osmotic laxative - provide osmotic load to draw water into the GI lumen

63

Magnesium hydroxide - use

Constipation

64

Magnesium hydroxide - side fx (3)

Diarrhea
Dehydration
Abused by bulimics

65

Magnesium citrate - mech

Osmotic laxative - provide osmotic load to draw water into the GI lumen

66

Magnesium citrate - use

Constipation

67

Magnesium citrate - side fx

Diarrhea
Dehydration
Abused by bulimics

68

PEG - mech

Osmotic laxative - provide osmotic load to draw water into the GI lumen

69

PEG - use

Constipation

70

PEG - side fx

Diarrhea
Dehydration
Abused by bulimics

71

Lactulose - mech

Osmotic laxative - osmotic load to draw water out of GI lumen

72

Lactulose - use

Constipation
Treat hepatic encephelopathy

73

Lactulose - side fx

Diarrhea
Dehydration
Abused by bulimics

74

Osmotic laxative - provide osmotic load to draw water into the GI lumen

MgOH
Mg Citrate
PEG
Lactulose

75

Constipation

MgOH
Mg Citrate
PEG

76

Constipation
Hepatic encephelopathy

Lactulose

77

Diarrhea
Dehydration
Abuse by bulimics

Osmotic laxatives - MgOH, Mg Citrate, PEG, Lactulose