Respiratory Drugs Reverse Flashcards Preview

USMLE > Respiratory Drugs Reverse > Flashcards

Flashcards in Respiratory Drugs Reverse Deck (39):
1

A agonists

Pseudoephedrine, Phenylephrine - mech

2

Acute exacerbation of asthma

Albuterol - use

3

Allergic asthma resistant to inhaled steroids and long-acting B2 agonists

Omalizumab - use

4

Allergy

Loratidine, Fexofendaine, Desloratadine - use

5

Allergy
Motion sickness
Sleep aid

Dipenhydramine, Dimenhydrinate, Chlorpheniramine - use

6

Antileukotreine that blocks leukotriene receptors (CysLT1)

Montelukast, Zafirlukast - mech

7

Antileukotriene that inhibits 5-lipoxygenase pathway
Blocks conversion of arachidonic acid to leukotrienes

Zileuton - mech

8

Asthma

Zileuton, Theophylline - use

9

Asthma - first line

Fluticasone, Budesonide - use

10

Asthma prophylaxis, long acting

Salmeterol, Formoterol - use

11

B2 agonist relaxes bronchial smooth muscle

Albuterol, Formoterol, Salmeterol - mech

12

Bronchial challenge test for asthma dx

Methacholine - use

13

Causes bronchodilation by inhibiting phosphodiesterase to increase cAMP levels due to decreased cAMP hydrolysis
Metabolized by CYP 450Blocks action of adenosin

Theophylline - mech

14

Direct vasodilatory effect on pulm and systemic arterial vascular beds
Inhibit platelet aggregation

Prostacyclin analogs (incl epoprostenol, iloprost) - mech

15

Disrupts disulfide bonds

N-acetylcysteine - mech

16

Far less sedating than 1st gen because decreased entry to CNS

Loratidine, Fexofenadine, Desloratadine - side fx

17

Flushing
Jaw pain

Prostacyclin analogs (incl epoprostenol, iloprost) - side fx

18

For aspirin-induced asthma

Montelukast, Zafirlukast - use

19

For Pulm HTN: Decrease pulm vascular resistance

Endothelin receptor antagonists (incl. bosentan) - use

20

Hepatotoxic

Zileuton - side fx

21

Hepatotoxicity (LFT)

Endothelin receptor antagonists (incl. bosentan) - side fx

22

HTN

Phenylephrine, Pseudoephedrine - side fx

23

HTN
CNS stimulation/anxiety

Pseudoephedrine - side fx

24

Inhibit cGMP PDE5 and prolong vasodilatory effect of NO

PDE-5 Inhibitors (incl sildenafil) - mech

25

Inhibiting endothelin-1 receptor

Endothelin receptor antagonists (incl. bosentan) - mech

26

M3 agonist

Methacholine - mech

27

Monoclonal anti-IgE AB, binds unbound serum IgE and blocks binding to FcERI

Omalizumab - mech

28

Mucolytic - loosen mucus plugs in CFAntidote for acetaminophen overdose

N-acetylcysteine - use (2)

29

Muscarinic antagonist that blocks muscarinic receptor competitively

Ipratroprium - mech

30

Narrow therapeutic window

Theophyilline - side fx

31

Prevent bronchoconstriction in asthmaCOPD

Ipratroprium - use

32

Pulm HTN

Prostacyclin analogs (incl epoprostenol, iloprost), PDE-5 inhibitors (sildenafil) - use

33

Reduce hyperemia, edema, nasal congestion
Open obstructed Eustachian tubes

Pseudoephedrine, Phenylephrine - use

34

Reversible inhibitors of H1 histamine receptor, 1st gen

Dipenhydramine, Chlorpheniramine, Dimenhydrinate - mech

35

Reversible inhibitors of H1 histamine receptor, 2nd gen

Loratidine, Fexofenadine, Desloratadine - mech

36

Sedation
Antimuscarinic
Anti-a-adrenergic

Dipenhydramine, Dimenhydrinate, Chlorpheniramine - side fx (3)

37

Steroid
Inhibit synthesis of all cytokinesInactivate NF-KB, the transcription factor that induces production of TNF-a and other inflammatory agents

Fluticasone, Budesonide - mech

38

Thins respiratory secretions, does not suppress cough reflex

Guaifenesin - use

39

Tremor
Arrythmia

Salmeterol, Formoterol - side fx (2)