Renal Drugs Reverse Flashcards Preview

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Flashcards in Renal Drugs Reverse Deck (30):
1

Binds AngII receptors
Does not increase bradykinin

ARBs (-sartans) - mech (2)

2

Carbonic anhydrase inhibitor
Gets rid of NaHCO3 from the body

Acetazolamide - mech

3

CATCHH
Cough
Angioedema
Teratogen
Creatinine Up (b/c GFR down)
Hyperkalemia
hTN

ACEi (-prils) - side fx

4

Direct renin inhibitor, blocks conversion of angiotensinogen to AngI

Aliskiren - mech

5

Diuresis in patients allergic to sulfa drugs

Ethacrynic acid - use

6

Drug overdose
Elevated ICP/IOP

Mannitol - use (2)

7

Edematous states (HF, cirrhosis, nephrotic syndrome, pulmonary edema)
HTN
Hypercalcemia

Furosemide, bumetanide, Torsemide - use (3)

8

Glaucoma
Urinary alkalinization
Metabolic alkalosis
Altitude sickness
Pseudomotor cerebri

Acetazolamide - use (5)

9

HTN

Aliskiren - use

10

HTN
HF
Idiopathic hypercalciuria
Nephrogenic diabetes insipidus
Osteoporosis

Chlorthalidone, Hydrochlorothiazide - use (5)

11

HTN
HF
Proteinuria
Diabetic nephropathy (slows GBM thickening)
Prevents unfavourable heart remodeling in chronic HTN

ACEi (prils) - use (5)

12

HTN
HF
Proteinuria
Diabetic nephropathy(If intolerance to ACEi)

ARBs (-sartans) - use (4)

13

Hypderaldosteronism
K+ depletion
HF

Spironolactone/Eplerenone - use (3)

14

Hypderaldosteronism
K+ depletion
HF

Triamterene, Amiloride - use (3)

15

Hyperchloremic metabolic acidosis
Paresthesias
NH3 toxicity
Sulfa allergy

Acetazolamide - side fx (4)

16

Hyperkalemia (arrhythmias)

Triamterene, Amiloride - side fx

17

Hyperkalemia (arrhythmias)
Endocrine effects with spironolactone

Spironolactone/Eplerenone - side fx (2)

18

Hyperkalemia
Decreased renal function
hTN
Cx in diabetics on ACEi/ARBs

Aliskiren - side fx

19

Hyperkalemia
Decreased renal function
hTN
Teratogen

ARBs (-sartans) - side fx (4)

20

Hypokalemic metabolic alkalosis
Hyponatremia
Hyperglycemia
Hyperlipidemia
Hyperuricemia
Hypercalcemia
Sulfa allergy

Chlorthalidone, Hydrochlorothiazide - side fx (7)

21

Inhibit ACE to decrease AngII
Decrease GFR by preventing constriction of efferent arterioles
Bradykinin goes up because ACE can't break it down

ACEi (prils) - mech (3)

22

K+ sparing diuretic
Blocks Na channels in CCT

Triamterene, Amiloride - mech

23

K+ sparing diuretic
Competitive aldosterone receptor antagonists in CCT

Spironolactone/Eplerenone - mech (2)

24

OH DANG!
Ototoxicity
Hypokalemia
Dehydration
Allergy (sulfa)
Nephritis (interstitial)
Gout

Furosemide, bumetanide, Torsemide - side fx (6)

25

OH DNG + can cause hyperuricemia

Ethacrynic acid - side fx

26

Osmotic diuretic.
Increases tubular fluid osmolarity to increase urine flow, decrease ICP/IOP

Mannitol - mech

27

Phenoxyacetic acid derivative
Same action as furosemide

Ethacrynic acid - mech

28

Pulmonary edema
Dehydration
Contraindicated in anuria, HF

Mannitol - side fx (3)

29

Sulfonamide loop diuretics
Inhibits NaK2Cl channel of ascending
Loop of Henle and prevents concentration of urine
Stimulates PGE release (blocked by NSAIDs)
Increases Ca excretion

Furosemide, Bumetanide, Torsemide - mech (4)

30

Thiazide diuretic
Inhibit NaCl reabsorption in early DCT to decrease diluting capacity of nephron
Decreases Ca excretion

Chlorthalidone, Hydrochlorothiazide - mech (3)