Respiratory Drugs Flashcards Preview

USMLE > Respiratory Drugs > Flashcards

Flashcards in Respiratory Drugs Deck (63):
1

Dipenhydramine - mech

Reversible inhibitors of H1 histamine receptor, 1st gen

2

Dimenhydrinate - mech

Reversible inhibitors of H1 histamine receptor, 1st gen

3

Chlorpheniramine - mech

Reversible inhibitors of H1 histamine receptor, 1st gen

4

Loratidine - mech

Reversible inhibitors of H1 histamine receptor, 2nd gen

5

Fexofendaine - mech

Reversible inhibitors of H1 histamine receptor, 2nd gen

6

Desloratadine - mech

Reversible inhibitors of H1 histamine receptor, 2nd gen

7

Dipenhydramine - use

Allergy
Motion sickness
Sleep aid

8

Dimenhydrinate - use

Allergy
Motion sickness
Sleep aid

9

Chlorpheniramine - use

Allergy
Motion sickness
Sleep aid

10

Loratidine - use

Allergy

11

Fexofendaine - use

Allergy

12

Desloratadine - use

Allergy

13

Dipenhydramine - side fx (3)

Sedation
Antimuscarinic
Anti-a-adrenergic

14

Dimenhydrinate - side fx (3)

Sedation
Antimuscarinic
Anti-a-adrenergic

15

Chlorpheniramine - side fx (3)

Sedation
Antimuscarinic
Anti-a-adrenergic

16

Loratidine - side fx

Far less sedating than 1st gen because decreased entry to CNS

17

Fexofendaine - side fx

Far less sedating than 1st gen because decreased entry to CNS

18

Desloratadine - side fx

Far less sedating than 1st gen because decreased entry to CNS

19

Guaifenesin - use

Thins respiratory secretions, does not suppress cough reflex

20

N-acetylcysteine - use (2)

Mucolytic - loosen mucus plugs in CF
Antidote for acetaminophen overdose

21

N-acetylcysteine - mech

Disrupts disulfide bonds

22

Pseudoephedrine - mech

A agonists

23

Phenylephrine - mech

A agonists

24

Pseudoephedrine - use

Reduce hyperemia, edema, nasal congestion
Open obstructed Eustachian tubes

25

Phenylephrine - use

Reduce hyperemia, edema, nasal congestion
Open obstructed Eustachian tubes

26

Pseudoephedrine - side fx

HTN
CNS stimulation/anxiety

27

Phenylephrine - side fx

HTN

28

Endothelin receptor antagonists (incl. bosentan) - use

For Pulm HTN: Decrease pulm vascular resistance

29

Endothelin receptor antagonists (incl. bosentan) - mech

Inhibiting endothelin-1 receptor

30

Endothelin receptor antagonists (incl. bosentan) - side fx

Hepatotoxicity (LFT)

31

PDE-5 Inhibitors (incl sildenafil) - use

Pulm HTN
Erectile Dysfn

32

PDE-5 Inhibitors (incl sildenafil) - mech

Inhibit cGMP PDE5 and prolong vasodilatory effect of NO

33

Prostacyclin analogs (incl epoprostenol, iloprost) - use

Pulm HTN

34

Prostacyclin analogs (incl epoprostenol, iloprost) - mech

Direct vasodilatory effect on pulm and systemic arterial vascular beds
Inhibit platelet aggregation

35

Prostacyclin analogs (incl epoprostenol, iloprost) - side fx

Flushing
Jaw pain

36

Albuterol - use

Acute exacerbation of asthma

37

Albuterol - mech

B2 agonist relaxes bronchial smooth muscle

38

Salmeterol - use

Asthma prophylaxis, long acting

39

Salmeterol - mech

B2 agonist relaxes bronchial smooth muscle

40

Formoterol - use

Asthma prophylaxis, long acting

41

Formoterol - mech

B2 agonist relaxes bronchial smooth muscle

42

Salmeterol - side fx (2)

Tremor
Arrythmia

43

Formoterol - side fx (2)

Tremor
Arrythmia

44

Fluticasone - use

Asthma - first line

45

Budesonide - use

Asthma - first line

46

Fluticasone - mech

Steroid
Inhibit synthesis of all cytokines
Inactivate NF-KB, the transcription factor that induces production of TNF-a and other inflammatory agents

47

Budesonide - mech

Steroid
Inhibit synthesis of all cytokines
Inactivate NF-KB, the transcription factor that induces production of TNF-a and other inflammatory agents

48

Ipratroprium - use

Prevent bronchoconstriction in asthma
COPD

49

Ipratroprium - mech

Muscarinic antagonist that blocks muscarinic receptor competitively

50

Montelukast - use

For aspirin-induced asthma

51

Montelukast - mech

Antileukotreine that blocks leukotriene receptors (CysLT1)

52

Zafirlukast - use

For aspirin-induced asthma

53

Zafirlukast - mech

Antileukotreine that blocks leukotriene receptors (CysLT1)

54

Zileuton - use

Asthma

55

Zileuton - mech

Antileukotriene that inhibits 5-lipoxygenase pathway
Blocks conversion of arachidonic acid to leukotrienes

56

Zileuton - side fx

Hepatotoxic

57

Omalizumab - use

Allergic asthma resistant to inhaled steroids and long-acting B2 agonists

58

Omalizumab - mech

Monoclonal anti-IgE AB, binds unbound serum IgE and blocks binding to FcERI

59

Theophylline - use

Asthma

60

Theophylline - mech

Causes bronchodilation by inhibiting phosphodiesterase to increase cAMP levels due to decreased cAMP hydrolysis
Metabolized by CYP 450
Blocks action of adenosin

61

Theophyilline - side fx

Narrow therapeutic window

62

Methacholine - use

Bronchial challenge test for asthma dx

63

Methacholine - mech

M3 agonist