Flashcards in USMLE CBSSA 2 Deck (40):
What is the source of urea production?
Coarse facial features, restricted join movement, high plasma levels of lysosomal enzymes. Dx and mechanism?
I-cell disease - proteins are secreted extracellularly instead of going to lysosomes (b/c mannose phosphorylation failure)
Speech is fluent with many grammatical errors, impaired comprehension and repetition
Antibody required to dx RA?
Anti-IgG antibody (Rh factor)
How do you treat CML?
What is ritonavir's MoA?
What is zanamivir's MoA?
Inhibit influenza neuraminidase - decrease release of virions
What do you give to treat ingestion of heavy isotope/radioactive substance?
What factors lead to granulomas?
What enzyme increases right after insulin treatment?
Glucokinase (b/c uptake of glucose)
What drugs cause constricted pupils?
Morphine, heroin, methadone
What property of an anesthetic determines rapid onset?
Low blood solubility
Proximal muscle weakness, tender shins, high PTH, low Ca. Dx?
Binding of what receptors results in symptoms of hyperthyroidism?
Nuclear/retinoid X binding to DNA
What are the features of normal pressure hydrocephalus?
Wet, wobbly, wacky
Normal PaO2 with low O2 content
Finding a difference when there is none. What type of error?
Left dominant circulation, route for angioplasty of artery supplying diaphragmatic surface & AV node of heart
LCA, LCX, PDA
Hypoxemia post MI cause
Increased pulmonary capillary pressure
What nerve innervates the back of the pharynx?
Duchenne muscular dystrophy is from a problem in what area of the muscle?
Cocaine use puts the fetus at the risk of what?
Malignant cells from cervical cancer spread to which lymph nodes first?
Aneurysms of the PCA can lead to?
CN III palsy
Antidote for insecticide?
Falling on wrist, pain between abductor pollicis longus and extensor pollicis brevis tendons. Risk?
Avascular necrosis of scaphoid bone
Painful feet 2nd to diabetes. Quality?
What is the role of iKB in NFKB transduction pathway from IL-1 binding to IL-6 induction?
iKB releases NFKB after undergoing phosphorylation
What is the mode of inheritance of cleft lip and palate?
What is the mechanism of fomepizole?
Blocks alcohol dehydrogenase, prevents conversion of methanol to formaldehyde
Nerve responsible for dorsiflexing the foot?
Deep fibular (peroneal)
Burnt almonds smell? Treatment?
Cyanide poisoning, treat with amyl nitrite
Decrease in lung surfactant leads to a change in what other lung property?
Lung elastic recoil
Alcoholic with poor wound healing. Why?
Vit C deficiency so can't hydroxylate collagen
What cells are TB found in?
Macrophages (lysosomes, to be precise)
Resistant to ampicillin but not to ceftriaxone. Feature?
What does primaquine do to treat P. vivax?
Sudden onset of double vision, periodic episodes of blurred vision, mild swelling and tenderness of the face, mild normochromic anemia, ESR of 60. Dx?
What acid-base state and volume state do loop diuretics cause?
Met alk, volume contraction