USMLE CBSSA 2 Flashcards Preview

USMLE > USMLE CBSSA 2 > Flashcards

Flashcards in USMLE CBSSA 2 Deck (40):
1

What is the source of urea production?

Glutamate

2

Coarse facial features, restricted join movement, high plasma levels of lysosomal enzymes. Dx and mechanism?

I-cell disease - proteins are secreted extracellularly instead of going to lysosomes (b/c mannose phosphorylation failure)

3

Speech is fluent with many grammatical errors, impaired comprehension and repetition

Wernicke's aphasia

4

Antibody required to dx RA?

Anti-IgG antibody (Rh factor)

5

How do you treat CML?

Imatinib

6

What is ritonavir's MoA?

Protease inhibitor

7

What is zanamivir's MoA?

Inhibit influenza neuraminidase - decrease release of virions

8

What do you give to treat ingestion of heavy isotope/radioactive substance?

Potassium iodide

9

What factors lead to granulomas?

IL-12, IFN-gamma

10

What enzyme increases right after insulin treatment?

Glucokinase (b/c uptake of glucose)

11

What drugs cause constricted pupils?

Morphine, heroin, methadone

12

What property of an anesthetic determines rapid onset?

Low blood solubility

13

Proximal muscle weakness, tender shins, high PTH, low Ca. Dx?

Osteomalacia

14

Binding of what receptors results in symptoms of hyperthyroidism?

Nuclear/retinoid X binding to DNA

15

What are the features of normal pressure hydrocephalus?

Wet, wobbly, wacky

16

Normal PaO2 with low O2 content

Anemia

17

Finding a difference when there is none. What type of error?

Type 1

18

Left dominant circulation, route for angioplasty of artery supplying diaphragmatic surface & AV node of heart

LCA, LCX, PDA

19

Hypoxemia post MI cause

Increased pulmonary capillary pressure

20

What nerve innervates the back of the pharynx?

Vagus

21

Duchenne muscular dystrophy is from a problem in what area of the muscle?

Cytoskeleton

22

Cocaine use puts the fetus at the risk of what?

Prematurity

23

Malignant cells from cervical cancer spread to which lymph nodes first?

Internal iliac

24

Aneurysms of the PCA can lead to?

CN III palsy

25

Antidote for insecticide?

Atropine

26

Falling on wrist, pain between abductor pollicis longus and extensor pollicis brevis tendons. Risk?

Avascular necrosis of scaphoid bone

27

Painful feet 2nd to diabetes. Quality?

Burning

28

What is the role of iKB in NFKB transduction pathway from IL-1 binding to IL-6 induction?

iKB releases NFKB after undergoing phosphorylation

29

What is the mode of inheritance of cleft lip and palate?

Multifactorial

30

What is the mechanism of fomepizole?

Blocks alcohol dehydrogenase, prevents conversion of methanol to formaldehyde

31

Nerve responsible for dorsiflexing the foot?

Deep fibular (peroneal)

32

Burnt almonds smell? Treatment?

Cyanide poisoning, treat with amyl nitrite

33

Decrease in lung surfactant leads to a change in what other lung property?

Lung elastic recoil

34

Alcoholic with poor wound healing. Why?

Vit C deficiency so can't hydroxylate collagen

35

What cells are TB found in?

Macrophages (lysosomes, to be precise)

36

Resistant to ampicillin but not to ceftriaxone. Feature?

B-lactamases

37

What does primaquine do to treat P. vivax?

Kills hypnozoites

38

Sudden onset of double vision, periodic episodes of blurred vision, mild swelling and tenderness of the face, mild normochromic anemia, ESR of 60. Dx?

Temporal arteritis

39

What acid-base state and volume state do loop diuretics cause?

Met alk, volume contraction

40

Very long fatty acid chains, phytanic acid, pipecolic acid in the serum. What's missing in the cell?

Peroxisomes