gold usmle: anti-infective pharm Flashcards Preview

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Flashcards in gold usmle: anti-infective pharm Deck (42)
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1

Primaquine

Malaria profylaxis
5. Used for extraerythrocytic forms Plasmodium vivax or P. ovale

2

Ciporfloxacin

Quinolone derivative

3

Sulfonamides

PABA structural analogs
8. Inhibit Folic acid synthesis

4

Tertacyclines, anuria & the exception

Should not be used in anuric pt due to production of (-) Nitrogen balance & ↑d BUN levels.
10. Doxycycline is the exception

5

Ceftriazone

3rd generation cephalosporin
12. DOC for bacterial meningitis in kids (ie… HiB)
13. One dose txt of gonorrhea

6

Hepatic coma DOC

Neomycin (aminoglycoside) – it supresses the normal flora = ↓g NH4 production = ↓g free
nitrogen levels in the bloodstream.

7

Clavulanic acid

Irreversible (-)r of β lactamases, but ot of transpeptidase = use w/ a β lactamase sensitive
penicillin

8

Piperacillin

Txt Pseudomonas aeruginosa & Klebsiella
17. Broad spectrum antibiotic

9

Streptomycin (aminoglycoside)

Txt Mycobacterium tuberculosis

10

Isoniazid

Most commonly used drug for TB.
20. Usually combined w/ Rifampin and/or Ethambutol
21. Pre Txt w/ Pyridoxine (Vit B6) can prevent peripheral neuritis‘

11

Pyrantel Pamoate

Txt of Hookworm disease
23. Depolarizing NMJ (-)r

12

Buy “AT” 30, “CELL” at 50

A = Aminoglycosides
25. T = Tetracyclines
26. C = Chloramphenicol
27. E = Erythromycin (macrolide)
28. L = Clindamycin
29. L = Lincomycin

13

Cefoxitin

Txt intraabdominal infections (ie… w/ Bacteroides fragilis)
31. Traditional txt has been Clindamycin & Gentamycin

14

Chloramphenicol

Broad spectrum antibiotic
33. Bone marrow depression (common) – Aplastic anemia (rare)
34. Gray baby syndrome (chloramphenicol cannot be conjugated)
35. DOC Typhoid Fever (symptomatic Salmonella infection)
36. DOC HiB meningitis in kids – especially resistant strain to ampicillin

15

Nifurtimox

Txt trypanosomiasis

16

Metronidazole

Txt Leishmaniasis & Amebiasis
39. Good for anaerobic bacteria = Bacteroides fragilis
40. DOC Trichomoniasis
41. DOC Giardia lamblia

17

Txt P. carinii

TMP-SMX & Pentamidine

18

Tetracycline

Txt of Brucellosis & Cholera
44. Txt Rocky Mountain Spotted Fever
45. Txt spirochete infections = Lyme disease (Borrelia burgdorferi)

19

TMP-SMX

(-) dihydrofolate reductase activity

20

Benzathine Penicillin G

Long duration of action = given once every 3-4 weeks for Txt of Syphilis

21

Praziquantel

Txt Schistosomiasis (trematode [fluke] infections)

22

Melarsoprol

Txt Trypanosomiasis that has neurological symptoms

23

Stibogluconate

Txt Leishmaniasis

24

Fluconazole

Txt fungal encephalitis

25

Amphotericin B

Polyene antifingal

26

Ketoconazole MOA

(-) fungal ergosterol synthesis = disrupts membrane

27

Griseofulvin MOA

Accumulates in keratinized layers of the skin = used in dermatomycoses infections

28

Mefloquine

Anti malarial
56. Txt Chloroquine resistant strains = P. falciparum

29

Chloroquine

Txt for Malaria when inside RBC

30

Nifurtimox

DOC Chagas disease due to Trypanosoma cruzi