gold usmle: anti-neoplastic pharm Flashcards Preview

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Flashcards in gold usmle: anti-neoplastic pharm Deck (20)
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1

Cyclosporine

Protects against rejections from organ transplants
81. Does not induce bone marrow depression

2

Cyclophosphamide

Alkylating agent of both purine & pyrimidine bases of DNA
83. Txt CLL

3

Cisplatin’s toxicities

Nephro- & Ototoxicity

4

Methotrexate

Antimetabolite of folic acid: (-)dihydrofolate reductase

5

Leucovorin Rescue

Can block/reduce Methotrexate = ↑ folic acid via a reduced folate

6

Bleomycin toxicities

Pneumonitis & pulmonary fibrosis

7

Azathiorine

Used in organ transplantation = kidney allografts
89. Allopurinol can ↑ its activity by (-) its biotransformation to xanthine oxidase

8

MOPP

Chemotherapy used in the txt of Hodgkin’s disease
91. M = Mechlorethamine – nitrogen mustard
92. O = Oncovin (Vincristine) – prevents microtubule assembly
93. P = Procarbazine
94. P = Prednisone – glucocorticoid, inducing apoptosis

9

Tamoxifen

(-) estrogen receptor
96. Txt of breast tumors, can see associated endometrial CA

10

Flutamide

Antiandrogenic
98. Used w/ Leuprolide (LH-RH analog)
99. Txt prostatic CA

11

Megestrol

(-) progesterone receptor
101. Txt endometrial CA

12

Fluoxymesterone

Androgenic steroid
103. Txt mammary CA in postmenopausal women

13

Methotrexate

Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase
105. Txt of ALL
106. Txt of Psoriasis

14

Brain tumor Txt

Lomustine
108. Carmustine – Causes pulmonary fibrosis

15

Streptozocin

Attaches to β cells
110. Txt of pancreatic insulinomas

16

Cytarabine (AraC)

Pyrimidine analog
112. DOC for AML

17

Dactinomycin

Used for Wilms tumor & rhabdomyosarcoma

18

Etoposide

Used for oat cell CA

19

Paclitaxel

Used for ovarian CA

20

Amifostine

Can ↓ nephrotoxicity due to chronic use of Cisplatin