Flashcards in Gold USMLE: Autonomic Nervous System pharm Deck (45)
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1
Epinephrine
α1, α2, β1, β2
2
Norepinephrine
α1, α2, β1 (no β2 activity)
3
GABA
Causes an inhibitory cell hyperpolarization
4
Muscarinic-r
Uses DAG & IP3 as 2nd messengers
5. Parasympathetic control
5
Bethanechol
Cholinergic. ↑ GI & Bladder motility. Txt atonic bladder post-op
6
Pilocarpine
Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation.
8. Txt acute glaucoma
7
Isoflurophate
Organophosphate. Irreversible acetylcholinesterase (-)r
8
Pralidoxime
2PAM. Reverses organophosphate binding to acetylcholinesterase
9
Neostigmine
Reversible acetylcholinesterase (-)r
12. Txt Myasthenia Gravis
10
Myasthenia Gravis
Anitbodies to Ach-r. ↑g muscular weakness due to Achs weak postsynaptic effect @ NMJ. Inactivates-r
11
Tubocurium
Nondepol. Competitive cholinergic N-r (-)r.
15. Prevents Ach binding but does not activate NMJ
16. ↑ Histamine release= ↓ BP & ↑ bronchospasm
12
Trimethaphan
Nonselectively binds N-r of the PS- and SNS
13
Pancurium
More potent than tubocurium w/o histamine release
14
Succinylcholine
Depol. Non competitive (-)r of muscle aciton
20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.
15
α1 & Eye
Mydriasis due to norepinephrine. Prazosin (-).
16
M-r & Eye
Miosis due to Ach. Atropine (-).
17
Sympathetic
Post ganglionic symapthetic fibers releases norepinephrine
18
Parasym.
Post ganglionic parasympathetic fibers release Ach
19
M3-r & Eye
Contracts sphincter = miosis. Contracts ciliary = accomodation.
20
M2-r & Heart
Negative chronotropy: ↓ HR = vagal arrest
27. Negative inotropy: ↓ contractility
21
M3-r & Lung
Bronchospasm ↑secretions
22
M3-r & GI
↑ motility (cramps & diarrhea). Involuntary defecation
23
Tacrine
Acetylcholine esterase (-)r. Txt Alzheimers
24
Atropine
DOC w/ vagal arrest
25
Glycoperrolate
M-r(-). Antispasmodic. Txt peptic ulcers.
26
Pirenzepine
M-r(-). Antispasmodic. Txt peptic ulcers.
27
Doxacurium
Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.
28
β bungarotoxin
Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending
29
α bungarotoxin
Irreversible N-r (-)r = ↓ action potentials
30