Gold USMLE: Autonomic Nervous System pharm Flashcards Preview

Question 1

1

Epinephrine

Answer

α1, α2, β1, β2

Question 2

2

Norepinephrine

Answer

α1, α2, β1 (no β2 activity)

Question 3

3

GABA

Answer

Causes an inhibitory cell hyperpolarization

Question 4

4

Muscarinic-r

Answer

Uses DAG & IP3 as 2nd messengers
5. Parasympathetic control

Question 5

5

Bethanechol

Answer

Cholinergic. ↑ GI & Bladder motility. Txt atonic bladder post-op

Question 6

6

Pilocarpine

Answer

Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation.
8. Txt acute glaucoma

Question 7

7

Isoflurophate

Answer

Organophosphate. Irreversible acetylcholinesterase (-)r

Question 8

8

Pralidoxime

Answer

2PAM. Reverses organophosphate binding to acetylcholinesterase

Question 9

9

Neostigmine

Answer

Reversible acetylcholinesterase (-)r
12. Txt Myasthenia Gravis

Question 10

10

Myasthenia Gravis

Answer

Anitbodies to Ach-r. ↑g muscular weakness due to Achs weak postsynaptic effect @ NMJ. Inactivates-r

Question 11

11

Tubocurium

Answer

Nondepol. Competitive cholinergic N-r (-)r.
15. Prevents Ach binding but does not activate NMJ
16. ↑ Histamine release= ↓ BP & ↑ bronchospasm

Question 12

12

Trimethaphan

Answer

Nonselectively binds N-r of the PS- and SNS

Question 13

13

Pancurium

Answer

More potent than tubocurium w/o histamine release

Question 14

14

Succinylcholine

Answer

Depol. Non competitive (-)r of muscle aciton
20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.

Question 15

15

α1 & Eye

Answer

Mydriasis due to norepinephrine. Prazosin (-).

Question 16

16

M-r & Eye

Answer

Miosis due to Ach. Atropine (-).

Question 17

17

Sympathetic

Answer

Post ganglionic symapthetic fibers releases norepinephrine

Question 18

18

Parasym.

Answer

Post ganglionic parasympathetic fibers release Ach

Question 19

19

M3-r & Eye

Answer

Contracts sphincter = miosis. Contracts ciliary = accomodation.

Question 20

20

M2-r & Heart

Answer

Negative chronotropy: ↓ HR = vagal arrest
27. Negative inotropy: ↓ contractility

Question 21

21

M3-r & Lung

Answer

Bronchospasm ↑secretions

Question 22

22

M3-r & GI

Answer

↑ motility (cramps & diarrhea). Involuntary defecation

Question 23

23

Tacrine

Answer

Acetylcholine esterase (-)r. Txt Alzheimers

Question 24

24

Atropine

Answer

DOC w/ vagal arrest

Question 25

25

Glycoperrolate

Answer

M-r(-). Antispasmodic. Txt peptic ulcers.

Question 26

26

Pirenzepine

Answer

M-r(-). Antispasmodic. Txt peptic ulcers.

Question 27

27

Doxacurium

Answer

Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.

Question 28

28

β bungarotoxin

Answer

Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending

Question 29

29

α bungarotoxin

Answer

Irreversible N-r (-)r = ↓ action potentials

Question 30

30

α1 & Eye

Answer

Contracts radial muscle = mydriasis (pupil dilation)

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Gold USMLE: Autonomic Nervous System pharm Flashcards Preview

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Epinephrine

α1, α2, β1, β2

Norepinephrine

α1, α2, β1 (no β2 activity)

GABA

Causes an inhibitory cell hyperpolarization

Muscarinic-r

Uses DAG & IP3 as 2nd messengers5. Parasympathetic control

Bethanechol

Cholinergic. ↑ GI & Bladder motility. Txt atonic bladder post-op

Pilocarpine

Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation.8. Txt acute glaucoma

Isoflurophate

Organophosphate. Irreversible acetylcholinesterase (-)r

Pralidoxime

2PAM. Reverses organophosphate binding to acetylcholinesterase

Neostigmine

Reversible acetylcholinesterase (-)r12. Txt Myasthenia Gravis

Myasthenia Gravis

Anitbodies to Ach-r. ↑g muscular weakness due to Achs weak postsynaptic effect @ NMJ. Inactivates-r

Tubocurium

Nondepol. Competitive cholinergic N-r (-)r.15. Prevents Ach binding but does not activate NMJ16. ↑ Histamine release= ↓ BP & ↑ bronchospasm

Trimethaphan

Nonselectively binds N-r of the PS- and SNS

Pancurium

More potent than tubocurium w/o histamine release

Succinylcholine

Depol. Non competitive (-)r of muscle aciton20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.

α1 & Eye

Mydriasis due to norepinephrine. Prazosin (-).

M-r & Eye

Miosis due to Ach. Atropine (-).

Sympathetic

Post ganglionic symapthetic fibers releases norepinephrine

Parasym.

Post ganglionic parasympathetic fibers release Ach

M3-r & Eye

Contracts sphincter = miosis. Contracts ciliary = accomodation.

M2-r & Heart

Negative chronotropy: ↓ HR = vagal arrest27. Negative inotropy: ↓ contractility

M3-r & Lung

Bronchospasm ↑secretions

M3-r & GI

↑ motility (cramps & diarrhea). Involuntary defecation

Tacrine

Acetylcholine esterase (-)r. Txt Alzheimers

Atropine

DOC w/ vagal arrest

Glycoperrolate

M-r(-). Antispasmodic. Txt peptic ulcers.

Pirenzepine

M-r(-). Antispasmodic. Txt peptic ulcers.

Doxacurium

Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.

β bungarotoxin

Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending

α bungarotoxin

Irreversible N-r (-)r = ↓ action potentials

α1 & Eye

Contracts radial muscle = mydriasis (pupil dilation)

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Uses DAG & IP3 as 2nd messengers
5. Parasympathetic control

Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation.
8. Txt acute glaucoma

2PAM. Reverses organophosphate binding to acetylcholinesterase

Reversible acetylcholinesterase (-)r
12. Txt Myasthenia Gravis

Anitbodies to Ach-r. ↑g muscular weakness due to Achs weak postsynaptic effect @ NMJ. Inactivates-r

Nondepol. Competitive cholinergic N-r (-)r.
15. Prevents Ach binding but does not activate NMJ
16. ↑ Histamine release= ↓ BP & ↑ bronchospasm

Depol. Non competitive (-)r of muscle aciton
20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.

Negative chronotropy: ↓ HR = vagal arrest
27. Negative inotropy: ↓ contractility

Acetylcholine esterase (-)r. Txt Alzheimers