gold usmle: CNS pharm Flashcards Preview

neuro > gold usmle: CNS pharm > Flashcards

Flashcards in gold usmle: CNS pharm Deck (62):
1

“TOM”

Short –acting BDZs:
2. Triazolam
3. Onazelam
4. Midazolam

2

Butyrophenone

Haloperidol & Droperidol

3

Atypical D4

Clozapine – Thioridazine – Olanzepine – Risperidone = Do not cause EPS

4

Flumazenil

BDZ antidote for OD

5

Methylphenidate

Txt attention deficit disorder

6

Phenytoin

Causes aplastic anemia/ gingival hyperplasia/ cleft lip & palate

7

Thiopental

Short acting Barb

8

Carbamazepine

DOC trigeminal neuralgia. Txt lennox gestaut seizures in kids

9

Atypical D4-r

Thioridazine; Olamzapine; Clozapine

10

Pimozide

Txt Tourette’s

11

Risperidone

Good for negative symptoms

12

Thioridazine

Most anti cholinergic neuroleptic

13

Haloperidol

Neuroleptic malignant hyperthermia due to chronic D2 block. give Dantrolene and Bromocriptine

14

Imirpamine

Enurisis

15

Clomirpramine

Txt OCD See aggressive behavior w/ use

16

Trazadone

19. Priapism

17

Bupropion

Helps to quit smoking

18

SSRIs

Primarily used for OCD

19

Fluoxetine

Good for negative symptoms

20

Phenelzine

Irreversible MAOI

21

Lithium

Txt manic phase of Bipolar Disorder
25. Causes goiter by (-) conversion of T4 to T3
26. Nephrogenic diabetes insipidus
27. Low salt diet will lead to Li toxicity

22

Alprazolam

DOC stage fright

23

Propranolol

Social phobia

24

κ-r

Spinal analgesia. Euphoria. ++euphoria. ++sedation. Constipation.

25

μ-r

Supraspinal analgesia. Dysphoria. +respiratory depression. +sedation.

26

Morphine & O2

Admin. is contraindicated to pts on morphine sedation= ↓ CO2 sensitivity and O2 admin. can stop breathing.

27

Morphine

↑ ICP = do not give to pt. with head trauma

28

Morphine OD

1.pinpoint pupils 2.↓’d respiraiton 3.coma

29

Meperidine

Anesthetic used during labor

30

Hydromorphone

μ(+) used in renal failure

31

Tramadol

Ambulatory txt for mod. to severe pain

32

Naloxone

Txt opioid OD. Reverses respiratory depression

33

Pentazocine

Part κ(+) & part μ(-)

34

Butorphenol

Part κ(+) & part μ(-)

35

Nalbuphene

Part κ(+) & part μ(-)

36

↓ GABA

↓ seizure focus= Barbs & BDZs

37

↓ Fast Na Ch.

↓ electrical activity spread = Phenytoin & Carbamazepine

38

Methoxyflurane

Can be nephrotoxic. Needs low MAC for anesthetic induction.

39

Enflurane

Can cause tonic/clonic muscle spasms

40

Isoflurane

Can cause bronchospasm

41

Halothane

Can cause ventricular extrasystoles & Malignant hyperthermia & Hepatitis

42

Nitric Oxide

No effect on HR. Needs high MAC for anesthetic induction.

43

Thiopental

Short acting Barb.

44

Ketamine

Dissociative anesthetic

45

Droperidol

Can be used in combo w/ Fentanyl for neuroleptoanalgesic effect
52. Neuroleptic tranquilizer. Has mild alpha block

46

Fentanyl

Can be used on combo w/ Droperidol for neuroleptoanalgesic effect
54. Used transdermally for chronic pain

47

Midazolam

Pre anesthetic. Induces amnesia

48

Primidone

Biotransformed to Phenobarb.

49

C & A delta Fibers

First fibers to be blocked w/ anesthesia

50

Esters

Procaine, Tetracaine, Benzocaine
59. Broken down and make PABA (allergen)

51

Amides

Lidocaine, Mepivaciane, Bupivaciane, Etidocaine= “i” before “caine” always an amide
61. Metabolized in the liver

52

Amphetamine

DA reuptake (-)’r. MAOI. Parkinson’s txt

53

Bromocriptine

D2(+). Used w/ L-Dopa for “on-off” phenomenon of Parkinson’s

54

Benztropine

Ant M w/ some DA reuptake (-). Parkinson’s txt

55

Amantidine

↓ DA reuptake. Can cause livido reticularis= skin mottling.

56

Diphenhydramine

Txt early Parkinson’s stages

57

Pergolide

> Effective & longer acting than Bromocriptine

58

Ethosuximide

DOC for Absence seizures

59

Tranylcypromine

. MAOI = antidepressant
reversible inhibitor

60

SSRI & MAOI

Fatal combo, especially seen with the use of Paroxetine or Fluoxetine (SSRIs) and Tranylcypromine (MAOI)

61

Labor opioids

Meperidine & Nalbuphine

62

Desipramine causes

Sudden cardaic death in children