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gold usmle: CNS pharm Flashcards

(62 cards)

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1
Q

“TOM”

A

Short –acting BDZs:

  1. Triazolam
  2. Onazelam
  3. Midazolam
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2
Q

Butyrophenone

A

Haloperidol & Droperidol

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3
Q

Atypical D4

A

Clozapine – Thioridazine – Olanzepine – Risperidone = Do not cause EPS

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4
Q

Flumazenil

A

BDZ antidote for OD

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5
Q

Methylphenidate

A

Txt attention deficit disorder

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6
Q

Phenytoin

A

Causes aplastic anemia/ gingival hyperplasia/ cleft lip & palate

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7
Q

Thiopental

A

Short acting Barb

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8
Q

Carbamazepine

A

DOC trigeminal neuralgia. Txt lennox gestaut seizures in kids

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9
Q

Atypical D4-r

A

Thioridazine; Olamzapine; Clozapine

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10
Q

Pimozide

A

Txt Tourette’s

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11
Q

Risperidone

A

Good for negative symptoms

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12
Q

Thioridazine

A

Most anti cholinergic neuroleptic

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13
Q

Haloperidol

A

Neuroleptic malignant hyperthermia due to chronic D2 block. give Dantrolene and Bromocriptine

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14
Q

Imirpamine

A

Enurisis

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15
Q

Clomirpramine

A

Txt OCD See aggressive behavior w/ use

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16
Q

Trazadone

A
  1. Priapism
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17
Q

Bupropion

A

Helps to quit smoking

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18
Q

SSRIs

A

Primarily used for OCD

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19
Q

Fluoxetine

A

Good for negative symptoms

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20
Q

Phenelzine

A

Irreversible MAOI

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21
Q

Lithium

A

Txt manic phase of Bipolar Disorder

  1. Causes goiter by (-) conversion of T4 to T3
  2. Nephrogenic diabetes insipidus
  3. Low salt diet will lead to Li toxicity
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22
Q

Alprazolam

A

DOC stage fright

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23
Q

Propranolol

A

Social phobia

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24
Q

κ-r

A

Spinal analgesia. Euphoria. ++euphoria. ++sedation. Constipation.

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25
μ-r
Supraspinal analgesia. Dysphoria. +respiratory depression. +sedation.
26
Morphine & O2
Admin. is contraindicated to pts on morphine sedation= ↓ CO2 sensitivity and O2 admin. can stop breathing.
27
Morphine
↑ ICP = do not give to pt. with head trauma
28
Morphine OD
1.pinpoint pupils 2.↓’d respiraiton 3.coma
29
Meperidine
Anesthetic used during labor
30
Hydromorphone
μ(+) used in renal failure
31
Tramadol
Ambulatory txt for mod. to severe pain
32
Naloxone
Txt opioid OD. Reverses respiratory depression
33
Pentazocine
Part κ(+) & part μ(-)
34
Butorphenol
Part κ(+) & part μ(-)
35
Nalbuphene
Part κ(+) & part μ(-)
36
↓ GABA
↓ seizure focus= Barbs & BDZs
37
↓ Fast Na Ch.
↓ electrical activity spread = Phenytoin & Carbamazepine
38
Methoxyflurane
Can be nephrotoxic. Needs low MAC for anesthetic induction.
39
Enflurane
Can cause tonic/clonic muscle spasms
40
Isoflurane
Can cause bronchospasm
41
Halothane
Can cause ventricular extrasystoles & Malignant hyperthermia & Hepatitis
42
Nitric Oxide
No effect on HR. Needs high MAC for anesthetic induction.
43
Thiopental
Short acting Barb.
44
Ketamine
Dissociative anesthetic
45
Droperidol
Can be used in combo w/ Fentanyl for neuroleptoanalgesic effect 52. Neuroleptic tranquilizer. Has mild alpha block
46
Fentanyl
Can be used on combo w/ Droperidol for neuroleptoanalgesic effect 54. Used transdermally for chronic pain
47
Midazolam
Pre anesthetic. Induces amnesia
48
Primidone
Biotransformed to Phenobarb.
49
C & A delta Fibers
First fibers to be blocked w/ anesthesia
50
Esters
Procaine, Tetracaine, Benzocaine | 59. Broken down and make PABA (allergen)
51
Amides
Lidocaine, Mepivaciane, Bupivaciane, Etidocaine= “i” before “caine” always an amide 61. Metabolized in the liver
52
Amphetamine
DA reuptake (-)’r. MAOI. Parkinson’s txt
53
Bromocriptine
D2(+). Used w/ L-Dopa for “on-off” phenomenon of Parkinson’s
54
Benztropine
Ant M w/ some DA reuptake (-). Parkinson’s txt
55
Amantidine
↓ DA reuptake. Can cause livido reticularis= skin mottling.
56
Diphenhydramine
Txt early Parkinson’s stages
57
Pergolide
> Effective & longer acting than Bromocriptine
58
Ethosuximide
DOC for Absence seizures
59
Tranylcypromine
. MAOI = antidepressant | reversible inhibitor
60
SSRI & MAOI
Fatal combo, especially seen with the use of Paroxetine or Fluoxetine (SSRIs) and Tranylcypromine (MAOI)
61
Labor opioids
Meperidine & Nalbuphine
62
Desipramine causes
Sudden cardaic death in children

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