psych Flashcards

(61 cards)

1
Q

a benzodiazepine mixed with alcohol can cause

A

CNS depression

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2
Q

antidote to BZDs

A

Flumazenil

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3
Q

benztropine

A

centrally acting anticholinergic agents that acts as an acetylcholine receptor antagonist
used to treat Parkinson’s

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4
Q

Flucytosine

A

potent antifungal

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5
Q

Naloxone

A

used to treat opioid overdose

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6
Q

naltrexone

A

opioid receptor antagonist
used to treat opioid addiction
can also be used to prevent relapses in alcohol dependence

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7
Q

Fluoxetine

A

common SSRI

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8
Q

buspirone

A

partial agonist at 5-HT Receptor
used as an alternative to BDZs to treat generalized anxiety disorder
does not potentiate CNNS depression of alcohol and has little potential for abuse and addiction

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9
Q

carbamazepine

A

anticonvulsant

can be used as a mood stabilizer in bipolar mood disorder

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10
Q

propranolol

A

non specific beta blocker

used for panic disorder and simple phobia

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11
Q

trazodone

A

heterocyclic antidepressant with sedative qualities that is used to treat depression complicated by insomnia
inhibits serotonin reuptake, but also acts as a partial serotonin agonist
can cause priapism

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12
Q

what IV BDZ is indicated to treat a pt in alcohol withdrawal with delirium tremens and mild withdrawal

A

Chlordiazepoxide
long-acting benzodiazepine - stim of GABA receptors
lorazepam, oxazepam, and diazepam would all also be acceptable

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13
Q

disulfiram

A

inhibits acetaldehyde dehydrogenase
causes accumulation of acetaldehyde with ingestion of alcohol
unpleasant effects help alcoholics maintain sobriety

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14
Q

haloperidol

A

typical antipsychotic

can be used in alcohol withdrawal pts suffering psychotic symptoms such as hallucinations

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15
Q

methadone

A

potent, long-acting, opioid agonist

treatment of opioid addiction

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16
Q

alcohols effect on the pupils

A

generally a dilator

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17
Q

signs of benzodiazepine overdose

A

respiratory depression along with hypotension, can have pupillary changes
treat with flumazenil

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18
Q

Fomepizole

A

alcohol dehydrogenase inhibitor
prevents the conversion of ethylene glycol and methanol to the toxic substances oxalic acid and formic acid
antidote for methanol or ethylene glycol poisoning

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19
Q

N-acetylcysteine

A

used for acetaminophen poisoning

indication for relieving mucus thickening in cystic fibrosis patients

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20
Q

Phenobarbital

A

long-acting barbiturate

used in pts with seizure disorders

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21
Q

Clozapine

A

atypical antipsychotic used to treat schizophrenia that is refractory to traditional therapy
blocks serotonin receptors in addition to the dopamine blockade common to all typical antipsychotics
bone marrow suppression specifically agranulocytosis is a dangerous side effect requiring frequent monitoring of WBC count

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22
Q

chlorpromazine

A

typical antipsychotic

similar profile to haloperidol

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23
Q

haloperidol

A

traditional antipsychotic
acts by blocking dopamine receptors and is not associated with agranulocytosis
causes extrapyramidal adverse effects

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24
Q

risperidone

A

atypical antipsychotic
similar to clozapine but does not produce agranulocytosis
can cause QT interval prolongation and metabolic aberrations

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25
thioridazine
traditional antipsychotic
26
schizoid personality disorder
marked by lifetime of voluntary social withdrawal
27
avoidant personality
pervasive pattern of social inhibition however they do desire companionship intense fear of rejection feelings of inadequacy and social ineptness to the extent they will participate socially only when they are certain to be liked
28
paranoid personality disorder
more socially engaged than those with schizoid | suspiciousness and mistrust of other people
29
schizophrenia
formal thought disorder with hallucinations or delusional thinking where pts with schizoid personality disorder have intact reality testing
30
schizophreniform disorder
same sxs as schizophrenia except that sxs last for at least one month but less than six months
31
schizotypal disorder
strikingly odd, peculiar notions, ideas of reference, illusions, magical thinking, and derealization
32
treatment of extrapyramidal side effects (torticollis) of haloperidol
benztropine anticholinergic agent reverses haloperidol action (high affinity for D2 receptor) of blocking dopamine receptors
33
uses of diazepam
hypnotic, sedative, anticonvulsant and muscle relaxant | treats chorea as muscle relaxant
34
fluphenazine
can induce potent D2 dopaminergic receptor blockade | alternative to haloperidol
35
prochlorperazine
typical antipsychotic agent with potent antidopaminergic effects
36
cocaine mech of action
prevents the reuptake of NE, dopamine, and serotonin by presynaptic transporter pumps in the central and peripheral nervous systems
37
phencyclidine
aggressive and impulsive behavior, nystagmus, and tachycardia NBDA receptor antagonist
38
barbiturates cause
respiratory depression and act by increasing BAGA activity by increasing the duration of Cl- channel opening
39
Bretylium and guanethidine
prevent fusion of presynaptic vesicles with the presynaptic membrane resulting in an inhibition of the release of NE into the synapse
40
What drug causes tardive dyskinesia
fluphenazine and haloperidol | result of long-term antipsychotic use
41
side effects of clozapine
atypical antipsychotic | agranulocytosis
42
side effects of lithium
nephrogenic diabetes insipidus, nausea, anorexia and mild diarrhea
43
ziprasidone
atypical antipsychotic | associated with QT prolongation and the risk of malignant ventricular arrhythmias
44
olanzapine
atypical antipsychotic blocks both serotonin and dopamine receptors can treat both positive and negative symptoms of schizophrenia
45
sertraline
SSRI | can cause serotonin syndrome when combined with MAO-I
46
Nortryptiline
TCA associated with the 3 C's convulsions, coma, and cardiotoxicity
47
schizophreniform disorder
schizophrenia less than 6 months
48
schizoaffective disorder
symptoms of schizophrenia as well as those of mood disorder
49
Pellagra
thickened skin with the 3 D's dermatitis, diarrhea, and dementia niacin (B3 deficiency) deficiency of tryptophan absorption
50
arginine is a precursor of
creatine, urea, and nitric oxide
51
phenylalanine is a precursor of
tyrosine, dopamine, norepinephrine, and epinephrine
52
tyrosine is a precursor of
dopamine, norepinephrine, and epinephrine
53
how does depression effect sleep
``` disrupted sleep increased time in REM decreased REM latency decreased delta waves characteristic of stage 3 and 4 treated with SSRI - fluoxetine ```
54
lysergic acid diethylamide is
LSD | hallucinations, delusion, and dilated pupils
55
Methylphenidate is used to treat, by what mechanism
ADHD | increases presynaptic release of NE
56
buproprion is used to treat | what pt population is it contraindicated for
antidepressant | contraindicated in pts with anorexia nervosa because it increases the risk of seizure in this population
57
an SSRI that treats both depression and anorexia
fluoxetine
58
an atypical antidepressant that induces weight gain
mirtazapine
59
best choice for first line treatment of delirium tremens
long-acting benzodiazepine | chlordiazepoxide
60
amitryptiline - class and common SEs
tricyclic anti-depressant red as a beet, dry as a bone, hot as a hare, blind as a bat, mad as a hatter, and full as a flask
61
what is used to reverse benzodiazepine overdose | by what mechanism
flumazenil | displacement of the drug from its binding site