Gold USMLE: Autonomic Nervous System pharm Flashcards Preview

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Flashcards in Gold USMLE: Autonomic Nervous System pharm Deck (45):
1

Epinephrine

α1, α2, β1, β2

2

Norepinephrine

α1, α2, β1 (no β2 activity)

3

GABA

Causes an inhibitory cell hyperpolarization

4

Muscarinic-r

Uses DAG & IP3 as 2nd messengers
5. Parasympathetic control

5

Bethanechol

Cholinergic. ↑ GI & Bladder motility. Txt atonic bladder post-op

6

Pilocarpine

Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation.
8. Txt acute glaucoma

7

Isoflurophate

Organophosphate. Irreversible acetylcholinesterase (-)r

8

Pralidoxime

“2PAM”. Reverses organophosphate binding to acetylcholinesterase

9

Neostigmine

Reversible acetylcholinesterase (-)r
12. Txt Myasthenia Gravis

10

Myasthenia Gravis

Anitbodies to Ach-r. ↑’g muscular weakness due to Ach’s weak postsynaptic effect @ NMJ. Inactivates-r

11

Tubocurium

Nondepol. Competitive cholinergic N-r (-)r.
15. Prevents Ach binding but does not activate NMJ
16. ↑ Histamine release= ↓ BP & ↑ bronchospasm

12

Trimethaphan

Nonselectively binds N-r of the PS- and SNS

13

Pancurium

More potent than tubocurium w/o histamine release

14

Succinylcholine

Depol. Non competitive (-)r of muscle aciton
20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.

15

α1 & Eye

Mydriasis due to norepinephrine. Prazosin (-).

16

M-r & Eye

Miosis due to Ach. Atropine (-).

17

Sympathetic

Post ganglionic symapthetic fibers releases norepinephrine

18

Parasym.

Post ganglionic parasympathetic fibers release Ach

19

M3-r & Eye

Contracts sphincter = miosis. Contracts ciliary = accomodation.

20

M2-r & Heart

Negative chronotropy: ↓ HR = vagal arrest
27. Negative inotropy: ↓ contractility

21

M3-r & Lung

Bronchospasm ↑secretions

22

M3-r & GI

↑ motility (cramps & diarrhea). Involuntary defecation

23

Tacrine

Acetylcholine esterase (-)r. Txt Alzheimer’s

24

Atropine

DOC w/ vagal arrest

25

Glycoperrolate

M-r(-). Antispasmodic. Txt peptic ulcers.

26

Pirenzepine

M-r(-). Antispasmodic. Txt peptic ulcers.

27

Doxacurium

Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.

28

β bungarotoxin

Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending

29

α bungarotoxin

Irreversible N-r (-)r = ↓ action potentials

30

α1 & Eye

Contracts radial muscle = mydriasis (pupil dilation)

31

α1 & Arterioles

Constiction: ↑TPR = ↑ Diastolic pressure = ↑ Afterload

32

α1 & Venules

39. Constriction: ↑ Venous return = ↑ Preload

33

α1 & Sex Function

Ejaculation

34

↑ Diastolic

↑ α1 = ↑TPR

35

↓ Diastolic

↑ β2; Direct acting vasodilators; (+)Cholinergics

36

β1 & Heart

(+)chronotropism = ↑HR.
44. (+)inotropism = ↑ contractility; ↑SV; ↑CO; ↑O2 consumption.
45. ↑ conduction velocity

37

Phenylephrine

α1 (+) Nasal decongestant.

38

β2(+) Asma Drugs

Metaproterenol; Albuterol; Terbutaline; Ritodrine; Salmeterol

39

Ritodrine/Turbutaline

Relaxes myometrium used in pre-mature labor pains

40

Phentolamine

Epi reversal. Blocks α, vasodilation occurs. Pt goes from HyperTN to HypoTN.
50. Txt pheochromocytoma = ↓BP

41

Terazosin

Txt BPH

42

Yohimbine

↑ sympathetic outflow = α2 (-). Txt impotence.

43

Cardioselective NMJ

Pancuronium = ↑HR due to atropine-like anti muscarinic vagolytic effect & Gallamine (-)r

44

Ecothiophate

Irreversible cholinesterase (-)r.

45

Pyridostigmine

Cholinomimetic that ↑s M & N-r effects. (-) acetylcholinesterase & plasma cholinesterase
56. DOC for the oral Txt of MG