Flashcards in Growth Factors Deck (10):
1
2 Main Functions of Neurotrophins
Increase survival of neurons and regulate formation/maintenance of synapses
2
4 Ntrophins and Their Rs
NGF binds TrkA
BDNF binds TrkB
NT-3 binds TrkC (also A and B)
NT-4/5 binds TrkB
3
Major Point about Rs in PNS
Some peripheral neurons/functions depend on one specific Trk, so if you knock out one might lose altogether
4
p75 R
Initiates cell death if binds Ntrophin or pro-form, or higher affinity for cell survival when complexed w/ Trk
5
Constitutive Pathway
Usually NGF and developmental, pro-protein matures, cleaved by furin, and targeted to constitutive release vesicles. Carried down postsyn retrograde to cell body to stimulate growth cascades
6
Regulated Pathway
Usually BDNF and mature, resistant to furin, pro packaged in secretory granules that accumulate at PM for depol release (can be cleaved by pro-prot convertases there or after release). Also transported to axon terminals of producing cell, and helps there? So autocrine or paracrine
7
3 Mechs BDNF Increases Synaptic Plasticity
Increases # of synapses, conductance of Rs, and expression of Rs
8
BDNF Val66Met Polymorphism
If Met there instead of Val, working memory is worse, in animals has shown lower BDNF levels
9
Chronic Stress Peripheral and 3 Central Effects
Increase peripheral levels of NGF, decrease central levels of NGF, BDNF, and NT-3
10