Neurodevelopment Flashcards Preview

Neuroanatomy > Neurodevelopment > Flashcards

Flashcards in Neurodevelopment Deck (13):
1

Notochord

Like first thing to develop, becomes vertebral column

2

2 Flexures

Cephalic becomes midbrain flexure, cervical disappears

3

2 Plates of Mantle Layer (gray matter)

Alar plate by roof plate and basal plates by floor plate

4

3 Pouchings from Neural Tube

Primary brain vesicles:
Forebrain (prosencephalon), Midbrain (mesencephalon), and hindbrain (rhombencephalon)

5

DRG Development

Derive from migrating neural crest cells, then send tracks to SC and tracks away

6

Neurodevelopment Basic Options

Neuroepithelial cells pretty much form everything, become neuroblasts or gliablasts. Ependymals cells are the remnant. The exception are microglia which come from mesenchyman/mac cell line

7

Epithelial To Mesenchymal Transition

Neural crest cells undergo to migrate throughout body. Relevant for cancer

8

Neurodevelopment Histological Pathway

Ectoderm undergoes neural induction (as opposed to becoming epidermis) to become neuroectoderm -> neural tube (can become floor or roof plate) -> neural pattering -> neurogenesis (can become neurons) -> oligodendrogenesis (can become oligodendrocytes) -> astrogliogenesis (can become you know) -> ependymal cells if didn't receive any of those factors

9

Nerve Growth

Induced by NGF to overgrow neurons so like all nerves innervate all myofibers, then undergo pruning to 1:1 ratio, this makes sure everything gets innervated

10

Rhombomeres

Somehow organize CNs to innervate specific pharyngeal arches?

11

Spina Bifida

Neural Tube Defect in which vert column doesn't quite close off. Dark hair in the region

12

3 Kinds of Meningocele

Meningocele - Arachnoid/subarachnoid space herniates out
Meningoencephalocele - brain tissue involved
Meningohydroencephalocele - ventricular lumen involved

13

Predictable Problems from Syrignomyelia

Anterior commisure right by central canal, so it can be affected. Maybe anterior horn/corticospinal problems