Pharmacology of CNS NTs Flashcards Preview

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Flashcards in Pharmacology of CNS NTs Deck (17):
1

Ionotropic NTs

Fast LGICs that go point to point and can be modified by local circuit presynaptic reg

2

Metabotropic NTs

Slow, GPCR coupled that are diffuse so go to multiple Rs for global effects

3

Off-Target Effects of NTs

CNS transmitters/Rs are also present in periphery

4

3 Glutamate Drugs (and major point)

No drugs to increase its signaling
Felbamate blocks NMDA Rs as an anti-convulsant
Phenylcyclindine (PCP) and ketamine occlude NMDA channel, can be hallucinogenic

5

NMDA R (4)

Implicated in learning/LPP
Increases Ca influx as well as Na
Requires Gly or Ser as coagonist
Ligand and voltage gated

6

4 GABA Drugs

Valproate - increase levels of GABA: anti-convulsant
Benzodiazepines/barbituates: enhance GABAa function: anti-seizure
Baclofen: GABAb agonist: reduce spasticity

7

Glycine (3)

Inhibitory, especially at SC
No useful drugs

8

AD Treatment

AChE Inhibitors

9

SN and VTA

DA neurons that project to striatum or n. accumbens (reward), respectively

10

2 NE Anti-Depressants

Desipramine - selective NE uptake inhibitor
Phenelzine - MAO inhibitor

11

3 Clinical Conditions Relating to 5-HT

Migraines
Too much: anxiety
Too little: depression

12

4 5-HT Drugs

Fluoxetine: selective 5-HT uptake inhibitor (anti-depression)
Buspirone: partial agonist, anxiolytic
Sumatriptan: agonist, anti-migraine
LSD - 5-HT2a agonist, psychadelic

13

ATP

Stored in small synaptic vesicles and coreleased w/ NT. Can either activate P2 Rs or be hydrolyzed to adenosine

14

Adenosine

Released from non-vesicular cytoplasmic stores or formed by ATP, activate P1 Rs

15

P1 R

Involved in sedative properties (& other shit) of adenosine. Caffeine blocks

16

NO

Diffusible gas involved in "retrograde" synaptic transmission

17

Endocannabinoids

Endogenous lipids bind to THC Rs that also involve retrograde signaling to decrease transmitter release