CSF Flashcards Preview

Neuroanatomy > CSF > Flashcards

Flashcards in CSF Deck (21):
1

2 Linear Acceleration Lesions

Coup and often even bigger countrecoup

2

Angular Acceleration

Brain doesn't move w/ the skull, so fluid can actually make it compressed but tentatorium and cerebri and shit

3

3 Driving Forces for CSF Flow

Pressure waves generated at production site
Respiration (inspiration CSF > cranium, expiration CSF > spinal column)
Ciliary Beat of Cells in Ependymal Lining

4

CSF Production

Carbonic anhydrase produces H2O and HCO3- , latter which it actively pumps into CSF while bring K+ in and Na out

5

2 Inhibitors of CSF Production

Oubain
Carbonic anhydrase inhibitors like diamox

6

Ion Composition of Nascent CSF

Higher Na and HCO3-, and less K+

7

CSF Absorption (4)

Follows pressure gradient so can reverse pathologically
Can't be blocked by oubain and follows bulk flow

8

CSF Pressure at Different Positions

Horizontal its constant, but upright actually neg pressure in head and high in spinal cord

9

Pneumocephalus

Connection with outside area means upright neg head pressure causes air to rush in

10

Monro-Kellie Principle

V(intracranial) is constant and is sum of V(blood/CSF/edema/whatever) so when one changes, the others respond

11

Death by Pressure

Increased CSF pressure means blood can't get to brain

12

Jugular/Abdominal Compressions

Causes increase in pressure bc prevents blood or CSF lumbar drainage

13

Sign of High CSF Pressure

Ocular structures coming out of macula densa not in same plane. Don't draw CSF fluid from lumbar bc pressure difference could cause Chiari

14

3 Symptoms of Increased Cranial Pressure

Headache
Vomiting
Blurred Vision

15

Cushing's Triad (& 3 symptoms)

Late stage increased cranial pressure: systolic hypertension, bradycardia, and depressed breathing

16

3 Kinds of Hydrocephalus

e vacuo - from vacuum, like surgically removing hemisphere
Communicating - no impairment of flow. Either increased production or decreased absorption of CSF
Non-communicating - impairment of flow, often aqueduct from scarring or something

17

Pseudotumor Cerebri (PTC)

Slight overproduction of CSF often in young females causes communicating hydrocephalus. Treat w/ diamox

18

2 Shunts for Communicating Hydrocephalus and 1 Important Point

Either to jugular or peritoneal, but needs check valve to prevent backflow of blood

19

2 Shunts for Noncommunicating Hydrocephalus

Ventriculo-cisternal or third ventriculostomy (create hole in 3rd ventricle to allow flow of CSF to basal cisternae

20

2 Components of BBB

BBB proper and Blood-CSF barrier of choroid plexus

21

2 Mechs of BBB Breakage and 3 Drugs

Osmotic: mannitol
Pharmacological: Bradykinin and zonulin (analogue to Vibrio cholerae zonula occludens toxin)