General Anesthetics

Question 1

3 IV GAs

Answer 1

Propofol, etomidate, thiopental

Question 2

Most Important Criterion

Answer 2

Controllable - rapid induction and recovery

Question 3

2 Mech Theories

Answer 3

Lipid Theory - alters membrane, higher lipid solubility = more potent
Protein Theory - binds hydrophobic regions of GABAa Rs and enhances function

Question 4

MAC (def and 2 points)

Answer 4

Minimum Alveolar concentration - 50% of patients don’t report pain on incision. Very steep curve. Also MACs for different drugs are additive

Question 5

Blood Solubility

Answer 5

Has to reach partial pressure to move into membranes/tissues, so high blood solubility means slow and low means fast

Question 6

4 Stages of Anesthesia (not always seen w/ modern drugs)

Answer 6

Analgesia
Excitement
Surgical Anesthesia
Medullary Paralysis (death)