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Flashcards in Hepatitis B Deck (12):
0

Currently available lab test for Hep B?

HBsAg
Anti-HBs
IgM anti-HBc
IgG anti-HBc
HBeAg
Anti-HBe

1

Why is HBcAg not routinely detected?

Because HBcAg is sequestered within an HBsAg coat.

2

Which Hep B lab test is most helpful in determining whether the pt is in the acute phase of viral hepatitis?

IgM anti-HBc is a marker for acute (less than 6 months ) hepatitis
1. It appears soon after the onset of infection and the detection of HBsAg.
2. It precedes by many weeks detectable levels of anti-HBsAg.
3. It generally disappears after 6-8 months.

3

Which lab market indicate infectivity for Hep B?

HBeAg
It may persist for years in pt with chronic disease and is associated with high infectivity.

4

Which marker indicates chronicity of Hep B?

1. HBsAg remains detectable beyond 6 months in chronic hepatitis.
2. HBeAg may persist for years in pt with chronic disease.
3. Persistent elevated ALT.

5

The relationship of Age of infection of Hep B and the risk of become chronically infected?

The likelihood of becoming chronically infected with hepatitis B is inversely related to the age at which the infection occurs.

6

What percent of Infants born to HBsAg-positive mothers will become Hep B carrier?

Up to 90%

7

What percent of children infected Hep B before the age of 5 will become Hep B carrier?

Between 25-50%

8

What percent of acutely Hep B Infected adults will become chronically infected?

6-10%

9

Transmission of HBV in the US?

- most HBV in fiction in the US with known routes of transmission result from sexual contact.

10

Hepatitis D virus

1. A defective virus
2. Co-infection with HBV is necessary for the replication and clinical expression of HDV
3. Preventing hepatitis B through vaccination with HBV vaccine will protect against hepatitis D

11

Risk of seroconversion due to sharps injury from a known positive source?

HBV----6-30% if not vaccinated
HCV----~2%
HIV----0.3%