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Flashcards in Solvevt Induced Diseases Deck (23):
0

N-hexane & methyl n-butylketone

Peripheral neuropathy

1

Benzene

Except neuropathies,
Bone marrow depressant
Aplastic anemia
Pancytopenia

2

Toluene

Except encephalopathy, Renal tubular acidosis

3

Methylene chloride

Acute MI
Methylene chloride is a paint stripper, after inhalation, it metabolized to CO, lead to CO poisoning and MI
Increase blood Hb-CO

4

Carbon tetrachloride

Myocardial sensitization

5

Methyl bromide

Ataxia, seizures

6

Chronic low level of organic solvent exposure can cause " painter's syndrome", with Sx of ?


HA, dizziness, asthenia, mood and personality change, inattentiveness, forgetfulness, and depression

7

Sx of Organic solvent exposure ?

Possible acute narcotizing (eg. Inhalated anesthetics)
Acute: brief, intense exposure = reversible encephalopathy
Chronic moderate exposure = dementing syndrome
Chronic low level exposure = "Painter's Syndrome "
Sensorimotor polyneuropathy may also occur

8

Painter's syndrome?

Caused by solvents
- depression
- retarded psychomotor performance
- personality change
- decrease in short memory

9

Bone marrow depressant:
Pancytopenia
Aplastic anemia
IARC class I: strongest association with AML

Benzene, aromatic hydrocarbons

10

Chloracne at head, neck and trunk

PCB (poly chlorinated biphenyls )

11

Scrotal cancer in chimney sweepers

PAH
-3 or more benzene rings fused
-Heavy in smoked meat
- carcinogen (lung, skin, bladder and kidney)

12

Antidote for Hydrofluoric acid

2.5% Calcium gluconate gel

13

Trigeminal neuralgia

Trichloroethylene (TCE)

14

Metabolized to carbon monoxide

Methylene chloride

15

Athrogenic

Carbon disulfide

16

Liver toxicity

Chlorinated hydrocarbons:
- carbon tetrachloride
- TCE ( trichloroethylene )
- Perchloroethylene

17

Hepatic angiosarcoma
Acro-osteolysis

Vinyl chloride

18

Magnense refiner with tremor

Parkinsonism

19

Solvent caused neuropathy
vs metal caused neuropathy

Demyelinating in solvent
Axonal change in metals

20

Demyelinating solvent?

N-hexane
Methyl-n-butyl ketone
Carbon disulfide
Acrylamide
Trichloroethylene

21

Sudden death after exposure to high levels of industrial solvents involving fluorocarbon ) freons in refrigerator mechanics), the probable mechanism?

Cardiac arrhythmia or simple asphyxiation.

22

Degreaser's flush

Trichloroethylene