Flashcards in Solvevt Induced Diseases Deck (23):
N-hexane & methyl n-butylketone
Bone marrow depressant
Except encephalopathy, Renal tubular acidosis
Methylene chloride is a paint stripper, after inhalation, it metabolized to CO, lead to CO poisoning and MI
Increase blood Hb-CO
Chronic low level of organic solvent exposure can cause " painter's syndrome", with Sx of ?
HA, dizziness, asthenia, mood and personality change, inattentiveness, forgetfulness, and depression
Sx of Organic solvent exposure ?
Possible acute narcotizing (eg. Inhalated anesthetics)
Acute: brief, intense exposure = reversible encephalopathy
Chronic moderate exposure = dementing syndrome
Chronic low level exposure = "Painter's Syndrome "
Sensorimotor polyneuropathy may also occur
Caused by solvents
- retarded psychomotor performance
- personality change
- decrease in short memory
Bone marrow depressant:
IARC class I: strongest association with AML
Benzene, aromatic hydrocarbons
Chloracne at head, neck and trunk
PCB (poly chlorinated biphenyls )
Scrotal cancer in chimney sweepers
-3 or more benzene rings fused
-Heavy in smoked meat
- carcinogen (lung, skin, bladder and kidney)
Antidote for Hydrofluoric acid
2.5% Calcium gluconate gel
Metabolized to carbon monoxide
- carbon tetrachloride
- TCE ( trichloroethylene )
Magnense refiner with tremor
Solvent caused neuropathy
vs metal caused neuropathy
Demyelinating in solvent
Axonal change in metals
Sudden death after exposure to high levels of industrial solvents involving fluorocarbon ) freons in refrigerator mechanics), the probable mechanism?
Cardiac arrhythmia or simple asphyxiation.