Flashcards in Icides Deck (11):
What is the best use of Diethyltoluamide (DEET)?
What is the best use of Manet?
What is the best use of Dichlorodiphenyltrichloroethane (DDT)?
What is the best use of Paraquat?
Pesticides chemical classes?
1. Organophosphates (O-Ps) - parathion, chlorpyrifos
3. Organochlorine - DDT
4. Pyrethrum - pyrethins
5. Herbicides - 2,4-D, Paraquat, 2,4-D 2,4,5-T - dioxin
Vx nerve gas - methylphosphonothioate
Sarin - methylphosphonofluoriolate
O-Ps vs carbamate
O-Ps inhibit acetylcholinesterase irreversible. Atropine + 2-PAM. 2-PAM (pralidoxime) must give within 24-48 hs after exposure.
Carbamate -cholinesterase deactivated spontaneously, less BBB penetration, no chronic effects. 2-PAM is not necessary for carbamate poisoning.
Measure/test for O-Ps poisoning ?
RBC cholinesterase more specific
Plasma or pseudo cholinesterase more sensitive
Carbamate pesticides poisoning medication choice?
Carbamate pesticides do not form stable bonds with the cholinesterase enzyme like the organophosphates, and 2-PAM has no effect in carbamate poisoning as its action is specific to the phosphorylated enzyme.