Hepatitis viruses

Question 1

all hepatitis viruses target ?

Answer 1

liver

Question 2

all hepatitis viruses primarily infect and replicate where

Answer 2

hepatocytes

Question 3

what is the family, genome, and virion of hepatitis A

Answer 3

family - picornoviridae
genome - (+) ssRNA
virion - nonenveloped

Question 4

what routes of transmission can ALL hepatitis virus be spread

Answer 4

Sexual and parenteral (injection)

Question 5

hepatitis A can be transmitted in what ways

Answer 5

sexual, parenteral, fecal-oral

Question 6

what is the incubation period for HAV

Answer 6

15-40 (short)

Question 7

what 2 hepatitis virus are known for having short incubation periods

Answer 7

hep A

hep E

Question 8

which hepatitis viruses are known for having long incubation periods

Answer 8

hep B (60-180)
hep C (60-120)
hep D (60-180)

Question 9

what is the family, genome, and virion of hepatitis B

Answer 9

family - hepadnaviridae
genome - circular dsDNA (unique)
virion - enveloped

Question 10

what hepatitis virus has a DNA genome

Answer 10

hep B (circular dsDNA)

Question 11

what hepatitis virus has a (-) ssRNA genome

Answer 11

hep D

Question 12

how can hep B be transmitted

Answer 12

sexual, parenteral, vertical

Question 13

what family of viruses must use reverse transcriptase ? why ?

Answer 13

hepadnaviridae

-b/c has an RNA intermediate

Question 14

what hepatitis virus has the smallest genome of all human viruses

Answer 14

hep B

Question 15

what hepatitis virus infection increases the risk of developing hepatocellular carcinoma (HCC)

Answer 15

hep B

Question 16

what hepatitis has a vaccination and what is unique about this vaccine

Answer 16

hep B

-requires multiple innoculations

Question 17

what hepatitis virus requires an activated HBV infection in order to replicate

Answer 17

hep D (rare in humans)

Question 18

chronic hepatitis infections occur in what hepatitis viruses

Answer 18

hep B (5%)
hep C (80%)
hep D

Question 19

what percentage of hepatitis B infections become chronic

Answer 19

5 %

Question 20

what percentage of hepatitis C infections become chronic

Answer 20

80 %

Question 21

what is the family, genome, and virion for hepatitis C infections

Answer 21

family - flaviviridae
genome - (+) ssRNA
virion - enveloped

Question 22

what hepatitis virus can cause extrahepatic disease mixed cryoglobulinemia

Answer 22

HCV

Question 23

what hepatitis viruses would you suggest interferon-alpha treatment ?

Answer 23

hep B
hep C
- reduces chances for chronic infections

Question 24

what hepatitis viruses could exhibit long term sequelae

Answer 24

HBV
HCV
HDV

Question 25

what hepatitis viruses are very rare in the US

Answer 25

HDV | HEV

Question 26

what is the family, genome, and virion of Hep D

Answer 26

family - deltaviridae genome - (-)ssRNA virion - enveloped

Question 27

what is the family, genome, and virion of Hep E

Answer 27

family - calciviridae genome - (+)ssRNA virion - nonenveloped

Question 28

what hepatits virus has the highest percentage of individuals being seropositive in the US (have Ab to the virus)

Answer 28

Hep A

Question 29

what hepatitis virus has the highest statistics of causing chronic liver disease death in the US

Answer 29

Hep C

Question 30

what hepatitis virus has the most acute cases in the US

Answer 30

Hep B

Question 31

which hep viruses can can be transmitted via fecal to oral

Answer 31

HAV HEV -NOT vertical though

Question 32

which hep viruses can be transmitted vertically from mom to baby

Answer 32

HBV HCV HDV