"Other" Mucosal Pathogens Flashcards Preview

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Flashcards in "Other" Mucosal Pathogens Deck (23):
1

what is the most common form of bacterial infections

urinary tract infection

2

what is the difference b/w uncomplicated UTI and a complicated UTI ?

Uncomplicated - all normal defense mechanisms are intact, only in lower urinary tract
Complicated - structural abnormality in urinary tract that has spread to kidney

3

what are the natural defenses found in the urinary tract

-voidance of bladder
-peristalsis
-one way ureter valves
-pH
-normal microbiota

4

what pathogen is the most common cause of UTI's

UPEC (uropathogenic E-coli)

5

what are fimbriae used for by pathogens

used specifically for adhering to uroepithelial wall

6

what 2 proteins does UPEC produce to help cause a UTI

aerobactin - binds iron from host which increases its virulence
hemolysin - toxin that lyses host cells

7

what 2 pathogens are known to cause uncomplicated UTI's

UPEC and Proteus mirabilis

8

if a UTI infection spreads to the kidney it is termed ?

pyelonephritis

9

which is a more severe form of uncomplicated UTI, UPEC or Proteus

Proteus mirabilis

10

what are the virulence factors of proteus mirabilis

flagella, fimbriae, hemolysins, IgA protease, urease

11

what does Prtoeus virulence facter IgA protease do ?

degrades IgA host Antibodies

12

what pathogen has urease as a virulence factor and why is that importatn

Proteus mirabilis
-makes pee more basic (raise pH) allowing for (1) better growth (2) a toxicity to renal cells (3) causes urinary stones

13

how do you diagnose which pathogen is causing a UTI

count bacteria in urine
-pH of piss (basic is proteus)
-presence of urease=proteus

14

how do you treat UTI

antimicrobials

15

what pathogen causes bacterial pneumonia

Klebsiella

16

what is the most important virulence factor of Klebsiella

has a antiohagocytic capsule allowing it to evade macrophages

17

what does aerobactin protein of Klebsiella do

sequesters iron from host making it more virulent

18

what pathogen is known as the "slow" bacterium

Helicobacter pylori

19

where does Helicobacter pylori tend to colonize and cause infection

mucous cells of the stomach

20

what pathogen can cause a number of diseases that are all preceded by chronic superficial gastritis

Helicobacter pylori

21

helicobacter pylori is very sensitive to what ?

acid

22

helicobacter pylori has the ability to downregulate somatostatin producing D cells, what is the effect on the host by this ?

inhibits gastrin, (makes stomach acid) which allows an environment for acid-sensitive helicobacter pathogens to grow

23

what is the difference b/w an invasive and non-invasive test for the diagnosis of helicobactor pylori

noninvasive - urea breath test (prescence of urease)
invasive - culture stomach lining