Herpesvirus and Papillomavirus Flashcards Preview

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Flashcards in Herpesvirus and Papillomavirus Deck (23):
1

what is the family, genome, and virion of both Type 1 and Type 2 Herpes Simplex

family - alphaherpesvirus
genome - dsDNA
virion - enveloped

2

what is the difference b/w alphaherpesvirus and beteherpesvirus with regards to length of reproduction cycles

alphaherpesvirus - short reproduction cycles allowing for rapid spread in culture
betaherpesvirus - long reproduction cycles

3

what is the difference b/w HSV-1 and HSV-2 w/regards to where they affect the human

HSV-1 above the waist
HSV-2 below the waist

4

what type of herpes virus is unique in that only 1/3 of infected people show symptoms ? Why is this ?

Alphaherpesvirus, b/c many people's immune systems can handle the infection w/o showing any symptoms

5

what is the difference b/w alphaherpesvirus and beta/gammaherpesvirus with regards to the host range it can affect

alphaherpesvirus - large host range
beta/gammaherpesvirus - restricted host range

6

what drug should be used to treat alphaherpesvirus, but will NOT eliminate latent infections

acylovir

7

what is the common name of the virus from the betaherpesvirus family

cytomegalovirus (CMV)

8

what is the common name of the virus from the gammaherpesvirus family

Epstein-Barr virus (EBV)

9

what are the 2 EBV associated carcinomas ?

-Burketts lymphoma
-Hodgkins lymphoma

10

Betaherpesvirus or CMV have the ability to compromise what host immune functions ?

-Block cell death (inhibit apoptosis)
-decrease NK cell activity
-decrease antigen presentation

11

Alphaherpesvirus or HSV-1 and HSV-2 have the ability to compromise what immune function ?

-Block cell death (inhibit apoptosis)
-decrease NK cell activity
-decrease antigen presentation

12

gammaherpesvirus or EBV have the ability to compromise what immune function ?

-Block cell death (inhibit apoptosis)
-decrease antigen presentation

13

what specific herpes virus persists in hematopoeitic progenitor cells, causing a chronic persistence (not latency)

CMV

14

where do EBV genome cells persist ?

memory B cells

15

Of all types of herpesvirus, which 2 are known to be self-limiting or not that severe

beta/gammaherpesviruses
-CMV and EBV

16

what is the family, genome, and virion of human papillomavirus

family - papilloviridae
genome - dsDNA
virion - nonenveloped

17

Human papillomavirus gains access through the _____, and needs active _____ cells in the host in order to replicate

skin,
basal lamina

18

how can the human papillomavirus be transmitted

skin to skin contact and fomites

19

what are the generic symptoms for all strains of the human papillomavirus

warts

20

if the human papillomavirus was to become oncogenic, what pathways would it have BLOCK to keep cell proliferation constant

-pRb pathway via E7
p53 pathway via E6

21

oncogenesis of human papillomavirus results in what type of cancer

cervical canver

22

most treatments for human papillomavirus are ablative, what does this mean

-burned off, cut off, lasered off

23

what is the name of the vaccine for Human papillomavirus

gardasil (Merck)