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Flashcards in HEPATOBILIARY 1 Deck (18)
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1

When Jaundiced in hepatitis, what is liver ALT levels?

super high in the 1000s

2

what causes high ALT?

hepatocyte membrane damage

3

When do you get Mallory bodies?

alcoholic hepatitis

4

when do you get centrilobular necrosis?

paracetomol toxicity

5

what is a Councilman body?

hepatocyte undergoing apoptosis

6

2 giveaways of alcoholic hepatitis?

Mallory bodies
Neutrophils

7

Cholestasis histologically see?

yellow brown dots (bile plug) in dilated biliary canaliculi

8

what is a hallmark feature of acute viral hepatitis B?

APOPTOSIS and ground glass hepatocytes

9

what happens to portal tracts in chronic hepatitis C? 4 things

1. lymphocytes infiltration
2. Fatty change
3. interface hepatitis
4. bridging fibrosis

10

Two examples of Non-alcoholic fatty liver disease?

DM and CHF

11

What is steatosis?

just fat (triglyceride) in the liver
fatty liver

12

3 types of steatosis are?

macrovesicular/large droplet - DIABETES
microvesicular/small droplet - REYE SYNDROME
Mixed type- ALCOHOL

13

Liver failure skin findings

Erythema, spider angioma, jaundice

14

Rusty smell in liver failure

mercaptans

15

Renal failure in liver failure

Hepatorenal syndrome (due to decreased renal perfusion)

16

Hemochromatosis- organ involvement

liver, joint, skin, pancreas (bronze diabetes), heart

17

Fulminant hepatitis (acute liver failure)- cause

Drug, superinfection, pregnancy, Wilson. (increasing ammonia)

18

Causes of alcoholic steatosis

decreased apoprotein decreased lipoprotein secretion, , increased fat biosynthesis, increased peripheral catabolism of fat