HEPATOBILIARY 1 Flashcards Preview

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Flashcards in HEPATOBILIARY 1 Deck (18)
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1
Q

When Jaundiced in hepatitis, what is liver ALT levels?

A

super high in the 1000s

2
Q

what causes high ALT?

A

hepatocyte membrane damage

3
Q

When do you get Mallory bodies?

A

alcoholic hepatitis

4
Q

when do you get centrilobular necrosis?

A

paracetomol toxicity

5
Q

what is a Councilman body?

A

hepatocyte undergoing apoptosis

6
Q

2 giveaways of alcoholic hepatitis?

A

Mallory bodies

Neutrophils

7
Q

Cholestasis histologically see?

A

yellow brown dots (bile plug) in dilated biliary canaliculi

8
Q

what is a hallmark feature of acute viral hepatitis B?

A

APOPTOSIS and ground glass hepatocytes

9
Q

what happens to portal tracts in chronic hepatitis C? 4 things

A
  1. lymphocytes infiltration
  2. Fatty change
  3. interface hepatitis
  4. bridging fibrosis
10
Q

Two examples of Non-alcoholic fatty liver disease?

A

DM and CHF

11
Q

What is steatosis?

A
just fat (triglyceride) in the liver
fatty liver
12
Q

3 types of steatosis are?

A

macrovesicular/large droplet - DIABETES
microvesicular/small droplet - REYE SYNDROME
Mixed type- ALCOHOL

13
Q

Liver failure skin findings

A

Erythema, spider angioma, jaundice

14
Q

Rusty smell in liver failure

A

mercaptans

15
Q

Renal failure in liver failure

A

Hepatorenal syndrome (due to decreased renal perfusion)

16
Q

Hemochromatosis- organ involvement

A

liver, joint, skin, pancreas (bronze diabetes), heart

17
Q

Fulminant hepatitis (acute liver failure)- cause

A

Drug, superinfection, pregnancy, Wilson. (increasing ammonia)

18
Q

Causes of alcoholic steatosis

A

decreased apoprotein decreased lipoprotein secretion, , increased fat biosynthesis, increased peripheral catabolism of fat