Renal cancer Flashcards Preview

PATH MAGIC > Renal cancer > Flashcards

Flashcards in Renal cancer Deck (25)
Loading flashcards...
1

Angiomyolipoma of the kidney is a tumor composed of an admixture of ?

smooth muscle, blood vessels and fatty tissue

2

Angiomyolipoma of the kidney frequently seen associated with

tuberous sclerosis, cardiac rhabdomyoma, skin hypopigmentation

3

The common benign renal neoplasms are ?

hemangioma, angiomyolipoma

4

(1) is the biggest risk factor for renal cancer

1. Tobacco smoking

5

Risk factors for renal cancer besides tobacco smoking

exposure to heavy metals, a history of long-term dialysis(acquired cystic disease).

6

(1) accounts for 80% of renal cancers.

1. Clear cell renal cell carcinoma

7

Both familial and sporadic types of clear cell renal cell carcinoma are associated with (1) of function of the (2) gene on chromosome (3)

1. loss
2. VHL tumor suppressor
3. 3

8

Clinical features of renal cell carcinoma are (1). Constitutional symptoms of (2) are often also present.

1. costovertebral angle pain, presence of a palpable mass and often hematuria (intermittent)
2. fever, malaise and weight loss

9

Renal cell carcinomas can produce a diverse number of symptoms from abnormal hormone production such as (1) which may confuse the diagnosis.

1. polycythemia, HTN, hypercalcemia and Cushing’s syndrome

10

Frequent metastatic sites of renal cell carcinomas are ?

lungs and bone

11

Tumor extension to involve perirenal or the presence of tumor within (1) are signs of poor prognosis

1. renal veins (renal vein invasion)

12

Urothelial carcinoma originates from the (1). (2) is a frequent presenting symptom. Larger tumors may produce (3)

1. urothelial lining cells of the renal pelvis
2. Hematuria
3. hydro nephrosis

13

Urothelial carcinoma may frequently be present in other portions of the (1)

renal pelvis, ureters or bladder

14

(1) is the most common primary kidney tumor in children (1 in 10,000 children) and the fourth most common pediatric malignancy. Tumors are bilateral in up to 10% of cases.

1. Wilms tumor or nephroblastoma

15

Wager syndrome patients have _____

aniridia, genital abnormalities, mental retardation

16

Wager syndrome features germline deletions of (1) and studies of these patients led to the identification of the (2).

1. 11p13
2. Wilms tumor associated gene (WT1)

17

Denys-Drash syndrome patients have ______

1. gonadal dysgenesis

18

Beskwith-Wiedmann syndrome patients (1) also have an increased incidence of Wilms tumors.

1. enlargement of individual body parts or body segments

19

WT1

Tumor suppressor gene

20

often come to light due to presence of an easily palpated very large abdominal mass that may even extend into the pelvic area

Wilms tumors

21

Features of VHL -

bilateral renal cell carcinoma, family history

22

Diverse symptoms from hormone production (systemic symptoms unrelated to the kidney itself)
Polycythemia
HTN
Hypercalcemia
Cushing’s syndrome

Renal cell carcinoma clinical features

23

aniridia, genital abnormalities, mental retardation‐33% lifetime risk

Wager syndrome

24

gonadal dysgenesis, renal abnormalities‐90% lifetime risk

Denys‐Drash syndrome

25

Triphasic combination of elements in WILMS tumor
1, 2, 3

blastemal
stroma;
epithelial cell types(abortive tubules or glomeruli)