Flashcards in Pathogenesis of diabetes mellitus Deck (30)
What does diabetes insipidus mean?
Passing lots of insipid urine - ADH insufficiency
List the diagnostic criteria for DM (all types)
- Fasting blood glucose (>126mg/dl- Fasting, >Need 2 abnormal tests )
Fasting blood glucose results
5.7% and 6.4%.: Likely prediabetes
≥ 6.5% diabetes
Oral glucose tolerance test
- 2-hour glucose
What are the symptoms of diabetes
P3- Polyphagia, Polydipsia, and Poluria
Define HbA1c and explain results
AGE (Hemoglobin+ Sugar complex)
Define gestational diabetes
women become very resistant to their own insulin, hyperglycemia by the end of 2nd trimester (1% to 3% of all pregnancy). Resolve spontaneously after delivery.
Which types of diabetes are insulin resistant?
NB: patients often have very high levels of insulin in circulation
What auto-antibodies can be found in T1DM?
Islet cell autoantigen (ICA) 512
IAA (insulin auto-antibody)
GAD (glutamic acid decarboxylase)
What is the typical presenting history for T1DM
history of weight loss, thirst, polyuria, nocturia, and fatigue
HLA DR3 and 4
Viral illness recently
High blood glucose level
High blood ketones
Why does weight loss occur in T1DM
Glucose is not absorbed into muscles/fat cells from the blood
Results in both fat and muscle bulk
Which genes are likely to increase susceptibility to T1DM?
CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and PTPN22 (Protein tyrosine phosphatase, non-receptor type 22 ), and insulin gene VNTRs(variable number of tandem repeats).
Which other autoimmune diseases are associated with T1DM?
> Thyroid disease (hyper and hypo) V. strongly associated
> Coeliac disease - strongly associated
> Addison's disease = primary adrenal insufficiency (hypocortisolism)
> Pernicious anaemia
> Inflammatory bowel disease (UC/Crohn's)
> Premature ovarian failure
Genes for DM 2
Transcription factor 7-like 2=TCF7L2
Peroxisome proliferator-activated receptor gamma=PPAR-γ or PPARG
Amyloid in islets
AGE: bind to a specific receptor (RAGE)- expressed macrophages and T cells
AGE: Col 4 + Sugar- non-enzymatic glycosylation
Atheroma in DM patients is an example of ______
AGE and Sorbitol induced pericyte injury
Cataract- in DM - mechanism____
Sorbitol-induced lens injury (osmotic injury)
Neuropathy in DM mechanism
Sorbitol-induced Schwan cell injury (osmotic injury)
Organopathy in DM is most likely due to______
diffuse thickening of glomerular basement membranes in DM is due to______
VGEF production is DM is due to________
PKC and RAGE
Secondary DM causes______
Drugs (corticosteroid, Thyroid hormone, Thiazides, Phenytoin )
Disease of exocrine pancreas: chronic pancreatitis.
Genetic syndrome: Downs syndrome
Endocrinopathes : Acromegaly, Cushing's syndrome.
Baby of a DM 2 mother= Possible complications
NRDS and pancreatic beta- cell hyperplasia
Pathogenesis of Gestational DM
Insuline resistance due to placental hormones/cytoines
Suger level of the baby after deliver in a DM2 mother