Key 1 of 2- Inflammation and Wound Healing Flashcards Preview

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Flashcards in Key 1 of 2- Inflammation and Wound Healing Deck (72)
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1

The function of LPS in gram-negative infections

PAF and NO= Peripheral vasodilatation

2

PGE2 functions (4)

Increased vascular permeability
Vasodilation
Fever
Pain

3

Leukotriene (C,D,E) functions (3)

Bronchoconstriction-Think Asthma after aspirin use
Vasoconstriction
Increased Permeability (via pericyte contraction)

4

classical complement pathway is activated by

IgG or IgM binding C1, so C2 and C4 will be low.

5

Alternative pathway activated by

Microbes directly activate complement, so C2 and C4 will remain normal.

6

Common product of all 3 complement pathway

C3 convertase, which produces C3a and C3b

7

C3a and C5a functions

Anaphylatoxins --> trigger mast celld egranulation

8

C3b function

Opsonin

9

3 key mediators of Redness and Warmth

Bradykinin
HIstamine
PGs

10

2 key mediators of swelling

Histamine
Tissue damage

11

2 mediators of pain

Bradykinin
PGE2

12

Mechanism of fever in bacterial infection/sepsis

Pyrogens from bacteria cause macrophages to release IL1 and TNF

IL1 and TNF increase COX in perivascular cells of hyopthal --> increase set point

13

What do selectins bind to on the leukocyte?

Silalyl Lewis X

14

3 structures mediating cellular adhesion

ICAM/VCAM on endothelial cell
Integrins on leukocyte

15

Leukocyte adhesion deficiency is a defect in

Integrins

16

3 hallmark features of LAD

1- Delayed separation of umbilical cord
2- Increased neutrophil count (detachment of marginated pool)
3- recurrent bacterial infection w/o pus formation

17

Chediak Higashi defect

Defective lysosomal trafficking regulator Gene (LYST)

Results in microtubule defects and poor phagolysosome formation

18

Clinical features of Chediak higashi (5)

-Recurrent pyogenic infections
- albinism (unable to move melanin to keratinocytes
-peripheral neuropathy
-Pancytopenia (no microtubules = no cell division)
-Giant granules in granulocytes

19

NADPH Oxidase deficiency

Chronic granulomatous disease (unable to produce reactive oxygen species)- get granuloma in bacterial infection!

20

CGD inheritance

X linked recessive

21

Hallmark of CGD

Recurrent infection with catalase-positive organisms

Pseudomonas, Candida, Ecoli, Staph

22

How to differentiate b/w CGD and MPO deficiency

Check free radical is present or not

23

2 mechanisms by which neutrophils kill

O2 dependent >>> O2 independent (lysosyme)

24

Major macrophage killing mechanism

Lysozyme...O2 independent (Stroke)

25

2 cytokines produced by TH1

IL2
INFy

26

TH2 CD4 cells secrete

IL4
IL5

27

Hallmark histology of granulomatous inflammation

Epithelioid Histiocytes (macrophages with lots of pink cytoplasm)
Giant cells + a Rim of lymphocytes+ a rim of fibrosis

28

2 cytokines involved in granuloma formation

INFy from TH1 cells --> macrophages become epithelioid histiocytes

29

XLinked Agammaglobulinemia defect

Phagocytosis defect

30

C1 inhibitor normal function

Prevents activation of compliment cascade