Hirsutism, Sertoli-Leydig Cell Tumor Flashcards Preview

Ob/Gyn > Hirsutism, Sertoli-Leydig Cell Tumor > Flashcards

Flashcards in Hirsutism, Sertoli-Leydig Cell Tumor Deck (16)
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0
Q

Signs of virilization?

A
  1. Clitoromegaly
  2. Deepening of voice
  3. Balding
  4. Increased muscle mass
1
Q

Most sensitive sign of excess androgen production?

Others?

A

Hirsutism

acne, oily skin, increased libido, virilization

2
Q

Differences in hair growth between ethnic groups are due to variations in?

A

Hair follicle concentration and 5-a-reductase activity

3
Q

Three stages of hair growth? Teach that determines hair length? Hair stability?

A

Anagen (growing phase)
Catagen (involution phase)
Telogen (quiescent please)

Anagen phase; telogen phase

4
Q

Effect of androgen on sex hormone binding globulin?

A

Decreases it

5
Q

Hirsutism; fast and recent growth versus slow and long-term growth?

A

Adrenal/ovarian tumors versus PCOS

6
Q

Virilization almost always suggests?

A

Androgen secreting Tumor (massive amounts of androgen)

7
Q

Congenital adrenal hyperplasia – most common defect?

A

21-hydroxylase

8
Q

Classic versus late-onset CAH?

A

Ambiguous genitalia in the newborn versus adult females with hirsutism and anovulation

9
Q

Cushing’s syndrome – history will have? Physical examination will show? Rule out with which lab test? Treatment?

A

Glucose intolerance;

Hypertension, buffalo hump, central obesity

Dexamethasone suppression test

Surgery

10
Q

Adrenal tumor – history will have? Physical examination will show? Rule out with which lab test? Treatment

A

Rapid onset virilization

Abdominal mass

DHEA-S

Surgery

11
Q

Congenital adrenal hyperplasia – history will have? Physical examination will show? Rule out with which lab test? Treatment

A

Ambiguous genitalia; family history

Hypotension

Elevated 17-hydroxyprogesterone

Cortisol and Mineralocorticoids

12
Q

PCOS – history will have? Physical examination will show? Rule out with which lab test? Treatment

A

Onset since menarche

Hirsutism, rarely virilization

Elevated LH/FSH ratio

OCP

13
Q

Sertoli-Leydig cell tumor – history will have? Physical examination will show? Rule out with which lab test? Treatment

A

Rapid onset

Hirsutism, virilization, adnexal mass

Elevated testosterone

Surgery

14
Q

Use of spironolactone disorders with excess androgen? Will help with? (But?)

A

Androgen antagonist; Hair growth (but average of six months before noticeable results

15
Q

Young girl with breast and vaginal development, but no hair growth. Mass noted. Most likely diagnosis?

A

Granulosa cell tumor