Flashcards in Pubertal Delay And Gonadal Dysgenesis Deck (9)
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Delayed puberty (vs primary amenorrhea)? Most common cause?
No sexual secondary characteristics by age 14 (versus no menarche by age 16)
Gonadal dysgenesis – most commonly from Chromosome abnormality
1
Four stages of pubertal development?
Thelarche, pubarche/adrenarche, growth spurt, menarche
(boobs, pubes, growth, squirt)
2
Hypergonadotropic hypogonadism – Hormone levels? Most common cause? Other causes?
High FSH, low estrogen
Turner syndrome
Radiation, chemotherapy, inflammation, torsion
3
Patient Turner syndrome have what in place of ovaries?
Gonadal streak – fibrous band of tissues
4
When to remove gonads in patient with gonadal dysgenesis to avoid neoplastic changes?
Gonadal dysgenesis with 46, XY
5
Hypogonadotropic hypogonadism – hormone levels? Main cause? Other causes?
Low FSH, low estrogen
Hypothalamic defect (Eating disorders, chronic illness, extreme exercise)
Hypothyroidism, Cushing's, pituitary adenoma's, craniopharyngiomas
6
Hypogonadotrophic hypogonadism – most commonly associated neoplasm?
Craniopharyngiomas
7
Management goals for patients with delayed puberty? Tx?
1. Initiate sexual maturation
2. Prevent osteoporosis (from hypoestrogenism Lumia)
3. Promote full height potential
OCP
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