Pubertal Delay And Gonadal Dysgenesis Flashcards Preview

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Flashcards in Pubertal Delay And Gonadal Dysgenesis Deck (9)
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Delayed puberty (vs primary amenorrhea)? Most common cause?

No sexual secondary characteristics by age 14 (versus no menarche by age 16)

Gonadal dysgenesis – most commonly from Chromosome abnormality

1

Four stages of pubertal development?

Thelarche, pubarche/adrenarche, growth spurt, menarche

(boobs, pubes, growth, squirt)

2

Hypergonadotropic hypogonadism – Hormone levels? Most common cause? Other causes?

High FSH, low estrogen

Turner syndrome

Radiation, chemotherapy, inflammation, torsion

3

Patient Turner syndrome have what in place of ovaries?

Gonadal streak – fibrous band of tissues

4

When to remove gonads in patient with gonadal dysgenesis to avoid neoplastic changes?

Gonadal dysgenesis with 46, XY

5

Hypogonadotropic hypogonadism – hormone levels? Main cause? Other causes?

Low FSH, low estrogen

Hypothalamic defect (Eating disorders, chronic illness, extreme exercise)

Hypothyroidism, Cushing's, pituitary adenoma's, craniopharyngiomas

6

Hypogonadotrophic hypogonadism – most commonly associated neoplasm?

Craniopharyngiomas

7

Management goals for patients with delayed puberty? Tx?

1. Initiate sexual maturation
2. Prevent osteoporosis (from hypoestrogenism Lumia)
3. Promote full height potential

OCP

8

LH/FSH ratio with gonadal dysgenesis?

Greater than one