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Flashcards in Thyroid Storm In Pregnancy Deck (9)
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0
Q

Most common cause of thyrotoxicosis in US? Physical exam sign that is suggestive?

Most common cause of hyperthyroidism postpartum? Mechanism?

A

Graves Disease, diffusely enlarged goiter

Destructive lymphocytic thyroiditis; high corticosteroid levels and pregnancy suppress autoimmune antibodies, resulting in a flare postpartum

1
Q

Thyroid storm?

A

Thyrotoxicosis leading to

  1. CNS dysfunction (coma/altered mental status)
  2. Autonomic instability (hyperthermia, hypertension, hypertension)
2
Q

biologically active thyroxine hormone?

A

T3

3
Q

Treatment of hyperthyroidism during pregnancy?

A

PTU > methimazole > radioactive iodine

methimazole possibly associated with plasia cutis congenital – Skin/scalp defects

4
Q

Tx of thyroid storm?

A
  1. PTU
  2. Beta blockers to control tachycardia
  3. Acetaminophen/cooling blankets for hyperthermia
  4. Steroids to prevent conversion of T4 to T3
5
Q

Antenatal treatment of maternal hyperthyroidism in pregnancy can result in? Management?

Failure to treat may result in?

A

Fetal hyper- or hypothyroidism. Maternal administration PTU or Intra-amniotic injection of thyroxine for fetal hyper- and hypothyroidism respectively

Non-immune hydrops and fetal demise

6
Q

Effect of maternal subclinical hypothyroidism in children? Possible prevention?

A

Adverse neurological development/abnormal intelligence

Levothyroxine in the first trimester

7
Q

Effect of pregnancy on thyroid hormones? Changes due to?

A

Increase in thyroid-binding globulin and total T4

No Change in free T4 or TSH

Estrogen

8
Q

Antibodies seen in destructive lymphocytic thyroiditis?

A

Antimicrosomal and anti-peroxidase