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Boards.CP.Micro > HSV,CMV,EBV,HHV6,HHV8,Adeno,Parvo,JC/BK,HPV,Pox > Flashcards

HSV,CMV,EBV,HHV6,HHV8,Adeno,Parvo,JC/BK,HPV,Pox Flashcards

-Cell Culture -HSV -CMV -EBV -HHV6 -HHV8 -Adenovirus -Porvovirus -JC/BK Virus -HPV

1
Q

Viral culture Cytopathic Effect (CPE):

-Tear shaped cells

A

Enterovirus

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2
Q

Viral culture Cytopathic Effect (CPE):

-CMV

A

Focal plaques in HDF

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3
Q

Viral culture Cytopathic Effect (CPE):

-Grape-like clusters

A

Adenovirus

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4
Q

Viral culture Cytopathic Effect (CPE):

-RSV

A

Syncytial cells

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5
Q

Viral culture Cytopathic Effect (CPE):

-HSV

A

Sweeping, globular cells

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6
Q

A positive IgG antibody may indicate what?

A

Current or Past infection

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7
Q

A positive IgM antibody indicates what?

A

Current infection

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8
Q

Viral Histology - RSV:

  • Nuclear/Cytoplasmic Inclusions
  • Syncytia (Y/N)
  • Notes
A
  • NONE

- Yes

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9
Q

Viral Histology - HSV :

  • Nuclear/Cytoplasmic Inclusions
  • Syncytia (Y/N)

-Notes (Cowdry type “?”, 3Ms)

A
  • Nuclear
  • Yes
  • Cowdry type A
  • 3Ms (Multinucleated, Molded nuclei, Marginated chromatin)
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10
Q

Viral Histology - Adenovirus:

  • Nuclear/Cytoplasmic Inclusions
  • Syncytia (Y/N)

-Notes

A
  • Nuclear
  • No

-“Smudge Cells”

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11
Q

Viral Histology - CMV:

  • Nuclear/Cytoplasmic Inclusions
  • Syncytia (Y/N)

-Notes

A
  • Nuclear&Cytoplasmic
  • No

-“Owl eye” inclusion, NOT multinucleated

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12
Q

Viral Histology - Measles:

  • Nuclear/Cytoplasmic Inclusions
  • Syncytia (Y/N)

-Notes

A
  • Nuclear&Cytoplasmic
  • Yes

-“Warthin-Finkeldey Giant cells”

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13
Q

Viral Histology - Rabies:

  • Nuclear/Cytoplasmic Inclusions
  • Syncytia (Y/N)
  • Notes
A
  • Cytoplasmic
  • No

-Negri bodies

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14
Q

Where does HSV type I go dormant?

A

Trigeminal Ganglia

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15
Q

Where does HSV type 2 go dormant?

A

Sacral Gangia

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16
Q

HSV definitive dx method.

A

Culture

-CPE within 2-3 days

17
Q

Neonatal CMV features.

A
  • Intracerebral calcifications
  • Petechial Rash (coag)
  • microcephaly
18
Q

EBV pathogenesis:

A

Pharyngeal or genital mucosa

-Infects B-lymphs via C3d receptor (CD21)

19
Q

What type of lymphocyte is seen in p. smear of EBV. (Atypical lymphocytosis)

A

-CD8+ T lymphocytes

20
Q

What is the site of EBV latency?

A

B-lymphocytes

21
Q

Uncontrolled activation of T/NK cells following EBV infection, leading to fuliminant primary EBC, that is frequently fatal

A 
Duncan disease  (X linked immunoproliferative disease)
-SH2D1A (SAP) gene
22
Q

What is the monospot test based upon?

A

Frequent presence of heterophile antibodies in EBV infection

23
Q

IHC stain that performs nearly as well as EBER.

A

-LMP1

24
Q

Virus responsible for a significant proprotion of child hood febrile seizures (highly neurotropic; may cause encephalitis)

A

-HHV6

25
Q

HHV8 associations. (3)

A
  • Kaposi sarcoma
  • Primary Effusion Lymphoma
  • Kastleman’s Dz in HIV+
26
Q

Adenovirus serotypes in most respiratory infections.

A

1-14 & 21

27
Q

Adenovirus serotypes ass. w/ hemorrhagic cystitis

A

11 & 21

28
Q

Adenovirus serotypes ass. w/ childhood gastritis

A

40 & 41

29
Q

Virus associated with Aplastic Anemia.

A

Parvovirus B19 (Erythrovirus)

30
Q

Where do JC & BK viruses lay dormant?

A

Urothelium and Lymphocytes

31
Q

Reactivation of JC virus features.

A
  • PML - Infects Oligos
  • AIDS (MC setting)
  • Smudgy nuclear inclusions in oligos
32
Q

Reactivation of BK virus features.

A
  • Hemorrhagic cystitis and/or
  • Polyomavirus nephropathy
  • Transplant (MC setting)
  • Decoy cells - smudgy nuclear inclusions
33
Q 
HPV type (order of frequency):
-Common wart
A

2, 1, 4

34
Q 
HPV type (order of frequency):
-Genital warts (condyloma acuminatum)
A

6, 11

35
Q 
HPV type (order of frequency):
-LSIL
A

6, 11

36
Q 
HPV type (order of frequency):
-HSIL
A

16, 18, 31, 33, 35

37
Q 
HPV type (order of frequency):
-AIS/Cervical Adenoca
A

18, 16, 45

Boards.CP.Micro (28 decks)

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