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Flashcards in immunology 2 Deck (17):
1

what are the cell surface antigens expressed on all cells

human leukocyte antigens (HLA)

2

what genes are responsible for cell mediated transplant rejection

Class I HLA genes

3

what genes are responsible for antibody mediated transplant rejection

Class II HLA genes

4

class II HLA targets of the major histocompatibility complex are only found where

vascular, endothelial and smooth muscle cells

5

what are the antigen presenting cells?

1. macrophages
2. dendritic cells
3. B cells

6

what causes a rush of calcium into a CD4 T cell

CD3

7

the rush of calcium into a CD$ T cell causes what to activate?

calcineurin activation

8

what are the 3 signals for activation of T lymphocytes

Signal 1. APCs present to antigen to the TCR on CD4+ T cells
Signal 2. costimulation signal must occur between APC and the T cell for the T cell to initiate the activation process
Signal 3. after IL-2 is produced during the activation process it interacts with the CD25 receptor. This speeds up cell cycle and begins monoclonal proliferation

9

What is a simplistic description of T cell activation signals

1. antigen presentation
2. costimulation signal
3. interaction of IL-2 with IL-2 receptor

10

What are the 5 types of antibodies

1. IgM
2. IgG
3. IgA
4. IgE
5. IgD

11

what is the first antibody to act when an infection is present

IgM

12

what is the name of the fragment of antigen binding portion of antibodies

FAB region

13

what is the compliment activating part of an antibody that is located on the "stem" of an antibody

FC portion

14

what is the only antibody that can cross the placenta

IgG

15

what antibody is a pentamer that lacks Fc portions

IgM

16

what antibody is found in fluid secretions (tears, saliva...) that prevents pathogens from adhering to epithelial cells

IgA

17

What antibody is often seen in allergic reactions that binds to Fc receptors on mast cells

IgE