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THERAPEUTICS III TEST 4 > Prostate Cancer > Flashcards

Flashcards in Prostate Cancer Deck (16):
1

what levels of PSA are considered normal

less than 4 = normal

2

what levels of PSA indicate either prostate cancer or BPH

4-10

3

a patients prognosis with prostate cancer is dependent on what?

1. gleason score
2. tumor size
3. local extent of primary tumor

4

what is the primary goal when treating advanced prostate cancer

reduce testosterone levels to castration levels

5

what are the 3 types of pharmacologic therapy

1. androgen deprivation therapy
2. chemotherapy
3. immunotherapy

6

what classes of drugs are considered androgen deprivation therapy

luteinizing hormone releasing hormone
gonadotropin releasing hormone
antiandrogens
androgen synthesis inhibitors

7

what are the LHRH agonists

leuprolide
goserelin
triptorelin

8

what are the major adverse reactions of LHRH agonists

tumor flare reaction - initial increase in testosterone
decrease in bone mineral density

9

what is a GnRH antagonist

degarelix (Firmagon)

10

what are the antiandrogen drugs

flutamide
bicalutamide
nilutamide

11

what is the indication for antiandrogens

metastatic prostate cancer and MUST be given in combination with LHRH agonists

12

what is prostate tumor cells that have acquired the ability to survive and proliferate with castration levels of testosterone

castration-resistant prostate cancer (CRPC)

13

what is the first line therapy for castration-resistant prostate cancer (CRPC) that has spread to organs

enzalutamide
docetaxel

14

what is the first line therapy for castration-resistant prostate cancer (CRPC) that has not spread to organs or bones (different from if it has spread to organs)

abiraterone

15

what is an immunotherapy option for CRPC who meet the criteria

sipuleucel-T

16

what is the criteria for men with metastatic CRPC for use of immunotherapy (Sipuleucel-T

ECOG