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Flashcards in transplant 2 Deck (18):
1

allograft rejection depends on what?

1. Recognition of antigen
2. Activation of T cells (CD4)
3. Proliferation of T cells (CD4)

2

what is hyperacute transplant rejection

Complement mediated and occurs immediately upon revascularization of the transplanted organ

3

what is acute transplant rejection

Caused by infiltration of the allograft by T cells which causes inflammatory and cytotoxic effects on the graft•

4

What is caused by antibodies directed against the vascular endothelium of the transplanted organ and is more difficult to treat than cellular rejection, but is usually responsive

vascular rejection (humoral rejection)

5

What is caused by antibodies directed against the vascular endothelium of the transplanted organ. It is also more difficult to treat than cellular rejection, but is usually responsive

chronic rejection

6

What labs are run before transplant occurs to prevent or minimize the risk of hyperacuteand acute rejection?

1.ABO blood testing (x2)
2.HLA (MHC) matching (kidney only)
3.Final crossmatching(x2)
4.Panel Reactive Antibody (PRA) (kidney only)

7

Type A Blood is compatible with what other types?

compatible with A and O

8

Type B Blood is compatible with what other types?

compatible with B and O

9

Type AB Blood is compatible with what other types?

compatible with A, B, AB, or O (universal recipient)

10

Type O Blood is compatible with what other types?

compatible with O (universal donor)

11

what antigen is a major barrier to kidney transplants?

HLA antigens (especially HLA-DR)

12

why are HLA antigen levels needed from donor in pre kidney transplant?

a recipient may have antibodies against donor HLA

13

what is the ideal HLA antigen mismatch

zero

14

what does it mean if agglutination occurs during T-cell and B-cell final cross match?

positive crossmatch, meaning recipient has preformed antibodies against the donor and hyperacute rejection would occur.

15

what test is routinely performed on patients awaiting kidney transplantation measuring anti-human (HLA) antibodies in the recipients blood?

panel reactive antibody (PRA)

16

what are 3 ways people often develop anti-HLA antibodies

1.Previous transplants
2.Blood transfusions
3.Pregnancy

17

what are 4 ways panel reactive antibodies are removed before transplantation?

1. Rituximab
2. IVIG
3. Immunoadsorption columuns
4. Bortezomib

18

High immunological risk patients should be induced with what

ATG (Rabbit)