Inflammation Flashcards Preview

Pathology > Inflammation > Flashcards

Flashcards in Inflammation Deck (13):
1

What is the inflammation response?

Host response to tissue damage, protective response

2

What triggers inflammation?

Foreign body, infection, ischemia, injury, immune

3

What is vascular permeability?

The blood vessel wall to open and increase flow

4

What is cellular reaction?

Recruit leukocytes to area, neutro and macro ingest and kill bacteria

5

What is margination?

White blood cells in the peripheral flow along lumen

6

What is rolling?

Selectins inhibit white blood cells to roll

7

What is adhesion?

Cytokines encourage this, white blood cells stop ad attach to endothelium

8

What is transmigration?

White blood cells encouraged to pass through extra-vascular space

9

Clinical signs if inflammation?

Redness, heat, swelling, pain, loss of function

10

What are the signs and symptoms?

Fever, tachycardia, hypo-tension, raised WBC and CRP

11

EXAMPLE: Peak age 10-30 years, central abdo pain migrates to right iliac fossa, worse on movement. N/V. Pyrexia, Raised HR, Raised WBC and CRP.

Acute appendicitis - Appendectomy - abbess.

12

EXAMPLE: Swollen, hot, red joint. Unable to move limb from pain. Pyrexia, Tachycardia, raised WBC. Risk: Prosthetic, recent surgery, trauma, RA.

Septic arthritis - Joint aspirate, IV antibiotics, Sepsis 6

13

EXAMPLE: Warm, swollen, sniff joints. Immune attack, healthy joint gets destroyed.

Rheumatoid arthritis - Steroids, DMARDS.