Flashcards in Inflammation Deck (13):
What is the inflammation response?
Host response to tissue damage, protective response
What triggers inflammation?
Foreign body, infection, ischemia, injury, immune
What is vascular permeability?
The blood vessel wall to open and increase flow
What is cellular reaction?
Recruit leukocytes to area, neutro and macro ingest and kill bacteria
What is margination?
White blood cells in the peripheral flow along lumen
What is rolling?
Selectins inhibit white blood cells to roll
What is adhesion?
Cytokines encourage this, white blood cells stop ad attach to endothelium
What is transmigration?
White blood cells encouraged to pass through extra-vascular space
Clinical signs if inflammation?
Redness, heat, swelling, pain, loss of function
What are the signs and symptoms?
Fever, tachycardia, hypo-tension, raised WBC and CRP
EXAMPLE: Peak age 10-30 years, central abdo pain migrates to right iliac fossa, worse on movement. N/V. Pyrexia, Raised HR, Raised WBC and CRP.
Acute appendicitis - Appendectomy - abbess.
EXAMPLE: Swollen, hot, red joint. Unable to move limb from pain. Pyrexia, Tachycardia, raised WBC. Risk: Prosthetic, recent surgery, trauma, RA.
Septic arthritis - Joint aspirate, IV antibiotics, Sepsis 6