Respiratory neoplastic Flashcards Preview

Pathology > Respiratory neoplastic > Flashcards

Flashcards in Respiratory neoplastic Deck (25):
1

What are the vast majority of lung tumours?

Carcinomas (arising from the lining of epithelium)

2

What are risk factors associated with lung tumours?

Smoking, industrial hazards, family history, immunodeficiency

3

What are the clinical signs of lung tumours?

Cough, weight loss, chest pain, dysponea

4

If the clinical feature is pneumonia, abscess, lobar collapse what is the pathological basis?

Obstruction of airway

5

If the clinical feature is pleural effusion what is the pathological basis?

Spread to pleura

6

If the clinical feature is hoarseness what is the pathological basis?

Laryngeal nerve invasion

7

If the clinical feature is dysphagia what is the pathological basis?

Oesophageal invasion

8

What is the staging and treatment for lung tumours?

TNM staging, surgery, chemotherapy, radiotherapy

9

What does small cell carcinoma have a strong relationship to?

Smoking - 1% in non smokers

10

Where does small cell carcinoma occur?

Bronchi and periphery, therefore mostly incurable by surgery

11

What is the histopathology of small cell carcinoma?

Small, tightly packed, darkly stained ovoid (resemble oats)

12

What are the cells appearance in small cell carcinoma?

Little cytoplasm, fine granular, absent nucleoli, pure or combined

13

What gender does squamous cell carcinoma mostly affect?

Males

14

Where does squamous cell carcinoma arise from?

Hilum, usually in area of squamous metaplasia (due to cigarette smoke) central bronchi

15

What is the histopathology of squamous cell carcinoma?

Resembles stratified squamous epithelium, keratin and inter-cellular bridges

16

What sex is adenocarinoma associated with?

Females and non smokers (75% found in smokers)

17

What rate do adenocarinomas grow at and what is the problem?

Grow slowly than SCC but metastasize early and widely

18

What is adenocarcinoma sometimes associated with?

Scarring - healed TB

19

What is the histopathology of adenocarcinoma?

Glandular elements - 80% contain mucin

20

What is large cell carcinoma?

Undifferentiated, larger

21

What is the most common site of metastatic neoplasms?

Lung, arriving my blood lymph or direct

22

What are the common primary sites?

Bowel, prostate, breast, kidney

23

What is the primary malignant pleural tumour?

Malignant mesothelioma

24

What is the increased risk of getting malignant mesothelioma?

Exposure to asbestos

25

What are the signs and symptoms of malignant mesothelioma?

Chest pain, dyspnoea, pleural effusions, 50% die in 12 months