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Flashcards in Inflammation and Healing Deck (14):
1

An "it is" means that the condition is associated with what?

Inflammation

2

What are 3 kinds of inflammation?

1-Acute (minutes to days, neutrophils, mast cells)
2-Chronic (1 day or more, lymphocytes)
3-Granulomatous (Aggregates of epithelia histiocytes, giant cells, lymphocytes)

3

What are the 5 clinical signs of inflammation?

1-Rubor
2-Tumor
3-Calor
4-Dolor
5-Loss of function

4

PgE2, Bradykinin, cytokines and substances P are partly responsible for what sign of inflammation?

Pain (dolor)

5

What are 5 laboratory signs of inflammation?

1-Leukocytosis with neutrophilia (acute) or lymphocytosis (chronic)
2-Eosinophilia (parasites, autoimmune, asthma)
3-Increased sedimentation rate
4-C-reactive protein
5-Procalcitonin

6

What are the 3 main cells in acute inflammation?

1-Mast cells
2-Neutrophils
3-Endothelium

7

Which cells are activated by trauma, involve IgE cross linking, kill through degranulation mechanisms?

Mast cells

8

Which cells are recruited to inflamed sites, phagocytose bacteria and toxins and form extracellular traps?

Neutrophils

9

What are 4 cells that are typical of chronic inflammation?

1-Lymphocytes
2-Macrophages
3-Sometimes eosinophils
4-Fibroblasts for tissue repair

10

Also called histiocytes, which cells are the major phagocytic and antigen presenting cell type and may rest in different organs?

Marcophages

11

What is the name of particles that are long and needle shaped and can have a brown beading coat that are too big for macrophages to ingest?

Asbestos

12

What are the two major lymphocyte cells?

B and T cells

13

What is the scar tissue strength after 1 week vs at 3 months?

1 week: 10% strength of normal
3 weeks: 70-80% (stays around this strength)

14

What are 3 problems in tissue repair?

1-process is slow
2-too much (hypertrophic scars, keloid, desmoid/fibromatosis)
3-To little (especially with steroids, may result in dehiscence)