Inflammation, Inflammatory disorders, Wound healing

Question 1

Activated Hageman factor activates

Answer 1

Coagulation and fibrinolytic system

Complements

Kinin system

Question 2

Alternative pathway of activating complements involves

Answer 2

Microbial products directly activate complements

Question 3

Arachidonic Acid released from phospholipid cell membrane by

Answer 3

Phospholipase A

Question 4

C1 inhibitor deficiency results in

Answer 4

Hereditary angioedema

Question 5

C5a is

Answer 5

Chemotactic for PMN

Question 6

Chediak-Higashi clinical

Answer 6

1. Increase risk of pyogenic infections
2. Neutropenia (Due to intramedullary death of PMN)
3. Giant granules in leukocytes
4. Albinism
5. peripheral neuropathy

Question 7

Chediak-Higashi syndrome is

Answer 7

AR protein trafficking defect characterized by impaired phagolysosome formation

Question 8

Classic pathway of activating complements involves

Answer 8

C1 binds IgG or IgM that is bound to antigen

Question 9

CREST is

Answer 9

• Calcinosis
• Raynaud phenomenon
• Esophageal dysmotility
• Sclerodactyly
• Telangiectasias of skin

Question 10

CREST lab findings

Answer 10

Anti-centromere AB

Question 11

Cu in wound healing

Answer 11

Cofactor for lysyl oxidase

Question 12

DiGeorge clinical

Answer 12

1. T-Cell deficiency due to lack of Thymus
2. Hypocalcemia due to the lack of parathyroids
3. Abdormalities of heart, great vessels and face

Question 13

DiGeorge sydrome due to

Answer 13

22q11 microdeletion

Question 14

DiGeorge sydrome is a developmental failure of

Answer 14

the 3rd and 4th pharyngeal pouches

Question 15

Drug induced SLE lab findings

Answer 15

Antihistone AB

Question 16

During adhesion, integrins are upregulated on leukocytes by

Answer 16

Cha and LTB₄

Question 17

E-selectin induced by

Answer 17

TNF and IL-1

Question 18

Fibroblast growth factor role in wound healing

Answer 18

Important for angiogenesis

Question 19

Granulomas are a collection of

Answer 19

Epithelioid histiocytes (macrophages with abundant pink cytoplasm) surrounded by giant cells and rim of lypmphocytes

Question 20

H₂O₂ to HOCl

Answer 20

MPO

Question 21

Hageman factor (Factor ΧΙΙ) is

Answer 21

inactive proinflammatory protein produced in liver

Question 22

Hyper-IgM syndrome due to

Answer 22

Mutated CD40L inhibiting class switching

Question 23

LAD clinical

Answer 23

1. Delayed separation of umbilical cord
2. Increase circulating PMN
3. Recurrent bacterial infections that lack pus formation

Question 24

latelet-derived growth factor role in wound healing

Answer 24

GF for endothelium, smooth muscle, and fibroblasts

Question 25

Leukocyte adhesion deficiency genetics

Answer 25

AR defect of Integrins

Question 26

O₂^- to H₂O₂

Answer 26

Superoxide Dimutase

Question 27

O₂ to O₂^-

Answer 27

Oxidative burst NADPH oxidase Source of CGD

Question 28

P-selectin released from

Answer 28

Weibel-Palade bodies bediated by histamine

Question 29

Scleroderma is

Answer 29

Autoimmune tissue damage with activation of fibroblasts and deposition of collagen

Question 30

Scleroderma lab findings

Answer 30

anti-DNA topoisomerase 1 (**Scl-70**)

Question 31

Sjögren lab findings

Answer 31

Anti-ribonucleoprotein AB (**anti-SS-A/Ro** and **anti-SS-B/La**)

Question 32

Sjögren sydrome is

Answer 32

Autoimmune destruction of lacrimal and salivary gland

Question 33

Sjögren syndrome increases risk of

Answer 33

B-cell (marginal zone) lymphoma

Question 34

SLE clinical

Answer 34

1. Fever and weight loss 2. Malar **'butterfly' rash** 3. Arthritis 4. Pleuritis and pericarditis 5. Psychosis 6. Renal damage 7. Libman-Sacks endocarditis 8. Anemia, thrombocytopenia, leukopenia

Question 35

SLE lab findings

Answer 35

ANA (**sensitive but not specific**) anti-dsDNA AB (**Specific**)

Question 36

TGF-α role in wound repair

Answer 36

Epithelial and fibroblast growth factor

Question 37

TGF-β role in wound repair

Answer 37

Fibroblast growth factor also inhibits inflammation

Question 38

T_H1 secrete

Answer 38

IL-2 (T cell growth factor and CD8 T-cell activator) IFN-γ (macrophag activator)

Question 39

T_H2 secretes

Answer 39

1. IL-4 (B-cell class switching to **IgG** and **IgE**) 2. IL-5 (Eosinophil chemotaxis and activation, maturation of B cells, **IgA** class switching) 3. IL-10 (Inhibits **T_H1**)

Question 40

TLR activation results in

Answer 40

upregulation of **NF-κB**

Question 41

TLRs are activated by

Answer 41

Pathogen-associated molecular patterns (**PAMPs**)

Question 42

Toll-Like receptors (TLR) are

Answer 42

Mediators of acute inflammation Located on cells of innate immune system

Question 43

Vit C in wound healing

Answer 43

Cofactor in hydroxylation of **proline and lysine**

Question 44

What AA metabolite attracts and activates PMN

Answer 44

LTB₄

Question 45

What AA metabolite mediates Pain and Fever

Answer 45

PGE₂

Question 46

What AA metabolites mediate vasodilation and increased vascular permeability

Answer 46

1. PGI₂ 2. PGD₂ 3. PGE₂

Question 47

What drugs cause SLE

Answer 47

Hydralazine Procainamide Isoniazid

Question 48

What test is used to screen CGD

Answer 48

Nitroblue tetrazolium test (*remains colorless if NADPH oxidase is defective*)

Question 49

What type of HS is Sjögren sydnrome

Answer 49

4

Question 50

What type of HS is SLE

Answer 50

2 and 3

Question 51

What upregulates ICAM and VCAM

Answer 51

TNF and IL-1

Question 52

Wiskott-Aldrich sydrome clinical

Answer 52

1. Thrombocytopenia 2. Eczema 3. Recurrent infections

Question 53

Wiskott-Aldrich syndrome due to

Answer 53

X-linked mutation of WASP

Question 54

X-linked Agammaglobulinemia is

Answer 54

Complete lack of Ig due to disordered B-cell maturation

Question 55

X-linked Agammaglobulinemia is due to

Answer 55

Mutated BtK

Question 56

Zinc in wound healing

Answer 56

Cofactor for **collagenase** which replaces Type 3 collagen with Type 1