Musculoskeletal Flashcards
(30 cards)
Achondroplasia genetics
AD mution of FGFR3
Osteogenesis imperfecta genetics
AD defect in collagen type 1 synthesis
Paget disease of bone is due to
Imbalance between osteoclast and osteoblast
3 stages of paget disease of bone
- Osteoclastic
- Mixed osteoblastic-osteoclastic
- Osteoblastic
Complications of Paget disease of bone
- High-output cardiac failure
- Osteosarcoma
Osteomyelitis in sickle cell caused by
Salmonella
Osteoid osteoma is
Benign tumor of osteoblasts
Osteoid osteoma arise in
Cortex of long bone
What age group does Osteoid osteoma occur in
Male <25
Osteochondroma is
Tumor of bone with an overlying cartilage cap
Osteosarcoma is
Malignant proliferation of osteoblasts
Risk factors to Osteosarcoma
Familial retinoblastoma
Paget
Radiation
Osteosarcoma arise in
The metaphysis of long bones
Distal femur or proximal tibia
Codman triangle is
Sunburst appearance and lifting of periosteum in osteosarcoma
Giant cell tumor arises in
Epiphysis of long bones
Distal femur or proximal tibia
Giant cell tumor on x-ray
Soap-bubble appearance
Ewing sarcoma translocation
t(11;22)
Ewing sarcoma arises in
Diaphysis of long bones
Joints affected by osteoarthritis
- Hips
- Lower lumbar spine
- Knees
- DIP
- PIP
Heberden nodes
Osteophyte formations in DIP due to osteoarthritis
Bouchard nodes
Osteophyte formation in PIP due to osteoarthritis
RA HLA is
HLA-DR4
Pannus is
Inflamed granulation tissue in RA
What is spared in RA
DIP
